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Biomedical subjects

D Passàli

Publications and source records attributed to D Passàli.

At least 37 records · Page 2Linked to original sources

[Nasal surfactant: biochemical and histological study].

The existence of a Surface Tension Lower Substance (STLS) in the lung and the Eustachian tube was established a few decades ago. The histological and physiological characteristics of the epithelium of the whole respiratory tract, from the nasal cavities to rhinopharynx and bronchiolar segments, induced the Authors to search for such a similar substance also in nasal secretion. To this purpose nasal secretions were studied using High Pressure Liquid Chromatography (HPLC) to determine the presence of phospholipids. In addition, ultrastructural examination of the nasal mucosa was performed looking for lamellar body-like structures of 2nd degree pulmonary cells.

Humans↗

Aspecific membranous laryngitis after infectious mononucleosis.

Aspecific membranous laryngitis is an unusual but very serious complication of viral infections. Here, we report the uncommon finding of infectious mononucleosis characterized by aspecific membranous laryngitis with fever, dysphonia and severe dyspnea in a 12-year-old girl. Endoscopy showed mucopus and sloughed epithelium forming a pseudomembrane covering almost all the supraglottal region and a supraglottal swelling including the epiglottis and arytenoids. The importance of suspecting diphtheria, epiglottitis, viral or bacterial croup and laringo-tracheo-bronchitis and including them in the differential diagnosis is emphasized.

Anti-Bacterial Agents↗

Acoustic rhinometry: practical aspects of measurement.

Rhinological diagnosis using acoustic rhinometry (AR) is described. The reliability of the test is improved by using a variable geometry craniostat allowing identical repositioning of the subject's head in various tests.

Adult↗

[Longitudinal study on nasal polyposis: etiopathogenetic, clinical and therapeutic aspects].

The etiopathogenesis of nasal polyposis is yet uncertain; furthermore surgical treatment often is not able to completely resolve this problem, being recurrence very common. In our Clinic, we operated 647 patients for nasal polyposis, either by traditional surgical or endoscopy, in the last ten years. The aim of this study is to compare the results of different surgical techniques, considering the percentage of recurrence. We found that endoscopic surgery give better result than traditional one because it allows to see the place of origin of nasal polyps in the ethmoide. The follow-up was lasting between 1 and 10 years; during this time we administered a topical corticosteroide, to a group of patients, for 1 month; in a second group, we administered furosemide, a diuretic drug. According to our data, the percentage of recurrence in the group treated with furosemide was smaller than in other group treated with corticosteroide.

Adolescent↗

[Presumed physiopathology of the nasal wall surgery and contemporary techniques of the inferior turbinates surgery].

The lateral wall of the nasal cavity is anatomically complex and covers several nasal functions: ventilation, conditioning of the air, protection. This region also plays a prime role in maintaining nasal-sinus homeostasis through dynamic regulation of the two-way exchange between the nasal cavity and paranasal sinuses. In light of the most recently acquired information, physio-pathological aspect of the lateral wall are discussed in terms of ventilation mechanisms and mucociliary clearance of the paranasal sinuses. In this light, the key to nasal-sinus physiology is clearly the perviousness of the side wall ostium and, above all, the status of the structures making up the "ostiomeatal complex". The anatomo-functional integrity of the lateral wall is fundamental for sinus ventilation 90% of which depends on passive diffusion of air through ostium. It is also a key to mucociliary clearance, always directed toward the main ostium. This rationale provides the basis for the so-called functional surgery of the lateral wall aimed at restoring ostium permeability. One structure in the lateral wall is a key to nasal physiology: the lower turbinate. Anatomical or functional alterations of the lower turbinate is one of the major causes of nasal stenosis. Pharmacological treatment of this pathologies is not always satisfactory, hence one leans toward surgical treatments. Nevertheless, the wide range of techniques available attests to the fact that there is still great deal of uncertainty in this regard. After having analysed the data available in the literature, the authors propose a comparison of some of the most frequently used forms of surgery: electrocauterization, cryotherapy, laser therapy, submucosal decongestion with or without luxation, turbinectomy. Follow-up based on rhinomanometric evaluation, rhinometry, TTMC, IgA assay and symptom scoring has been performed for 4 years. The results show that the submucosal decongestion technique, particularly the variation with lateral luxation, is considered most effective in resolving obstruction while respecting nasal physiology.

Humans↗

The rheological characteristics of nasal mucus in patients with rhinitis.

In this paper we have analyzed the physical properties of nasal mucus from 120 outpatients with rhinitis. We focused on the most relevant rheological features: viscosity, elasticity, adhesiveness, as well as ability to be spun ("spinability") or poured ("pourability"). A double-capillary type viscometer was used to measure viscosity and elasticity and the platinum ring method to measure adhesiveness. "Spinability" was measured with an automatic apparatus (Filancemetre Sefam) and "pourability" was determined by describing flow under gravity. Efficacy of nasal clearance was analyzed by measuring mucociliary transport time with an inert tracer using vegetal charcoal powder. Results showed that impaired nasal mucosal function in patients with rhinitis could be determined by studying rheological features in addition to measuring mucociliary activity. Information provided proved invaluable when considering possible treatment with agents affecting kinesis of nasal mucus.

Adhesiveness↗

[Trigemino-vegetative physiopathology in the central dysnociceptive biorhythms in primary headache].

The Headache is a common symptom: 80% of the population suffers from headache at least one time per year. This work is a review of new theories on neurovascular pathophysiology of primary headaches in a particular manner on rhinogenic headache. Besides, the authors report the results of a study carried out in 2262 children, who where attending the primary school, in order to investigate the relation between allergic rhinitis and headache in children. The present study suggests that the headache in allergic patients is related to nasal dysfunction always present in these cases.

Animals↗

Treatment of upper airways inflammation with nimesulide.

Nimesulide treatment for 7 to 10 days is shown to be effective in controlling the inflammatory process in upper airways disorders such as rhinitis, rhinosinusitis, rhinopharyngitis and tubaritis, and in middle ear disorder (secretory otitis media). A concomitant antibacterial is considered necessary in cases involving infection, in order to retain the improvements in mucociliary transport obtained with anti-inflammatory treatment. Nimesulide is also shown to be effective when given in combination with the mucolytic drug ambroxol.

Adolescent↗

Nasal vascularization: experiences using the microcorrosion technique in human foetuses.

The authors have studied the three-dimensional aspect of the vascular architecture of the nasal mucosa, using the microcorrosion method followed by scanning electron microscopical observation of casts of the vascular networks in both the septum and the lateral part of the nose. Batson's compound was introduced into the vascular system through the ascending aorta, in order to obtain a replica of the nasal mucosa vessels. Twelve- to 24-week-old foetuses obtained from spontaneous abortions were used for this purpose.

Arteriovenous Anastomosis↗

[Use of nimesulide in inflammations of the upper respiratory tract].

In a controlled clinical study of 40 patients, aged 18 to 65, suffering from acute inflammatory pathology of the upper respiratory tract or from a chronic form flaring into acute crisis, without any general symptoms of infection, were assigned at random to treatment with nimesulide in tablet form (100 mg x 2/day), or with phenylprenazone in capsules (200 mg x 2/day) for a period of seven days. In both groups a clinically significant reduction of the symptoms was obtained (congestion and edema of the pharyngeal mucosa, cough) as well as an improvement in the values of conductance and MCTt. Epigastralgy was evidenced in three subjects treated with nimesulide and in four treated with phenylprenazone. No significant variations of the laboratory parameters were found in either treatment group.

Adolescent↗