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Biomedical subjects

D Oliver

Publications and source records attributed to D Oliver.

119 records · Page 7Linked to original sources
PubMed1972

A modified procedure for fractionating histones.

A method is described, which is capable of fractionating histones obtained from any animal source into five major groups. Although the method is based on procedures initially developed by E. W. Johns (1964), involving differential solubility in solutions of acids and of ethanol, it gives a cleaner separation and possesses the considerable advantage that the starting material is whole histone rather than a nucleoprotein preparation.

Animals↗
PubMedDate not supplied

Results from a new renal transplantation unit.

158 kidneys, 9 from living related donors and 149 from cadavers, have been transplanted in the first 42 months of the establishment of a transplant unit at Oxford. Patients' ages ranged from 11 to 56 (mean 35) years. Azathioprine and prednisolone alone were used for immunosuppression, and a minimum-transfusion policy was in operation throughout. After cadaveric transplantation actuarial patient-survival is 70% and 68%, respectively, at the same intervals. 85% of patients who had a functioning graft are fully rehabilitated. Matching for HLA-DR, pregraft blood-transfusions, and the finding that a transplant could be performed in the presence of a positive B-cell crossmatch have proved to be the most significant of the many factors examined both prospectively and retrospectively. The function of the unit is based on dialysis and transplantation for all patients in end-stage renal failure, with transplantation being considered the first line of treatment for patients under the age of 56. The results of transplantation reported here, which have been achieved with conventional immunosuppressive therapy and minimum-transfusion policy, might be considered a standard against which modifications of the practice of renal transplantation can be compared.

Adolescent↗
PubMedDate not supplied

Evaluation of innovations in nursing practice: report and discussion.

AIM: To assess whether a pilot study conducted in the UK achieved its objective to reduce admissions to hospital and bed days in patients identified as suitable recipients of case management by community matrons. BACKGROUND: The Department of Health has advocated the use of nurse-led case management to improve the coordination of care and prevent inappropriate hospital admissions. METHOD: 66 patients and another 66 controls were identified for the 'Evercare' caseload according to criteria set by United Healthcare. Admissions data for the six months after entry into the study were collected from the hospital information system. FINDINGS: admission rates in both the control and intervention group decreased over time and there was no significant difference in rates between the two groups at six months. There was no demonstrable effect on length of stay either. Users were satisfied with the service and nurses cited several clinical stories implying benefits for individual patients.

Aged↗