From March, 1979 to March, 1983, 26 orthotopic liver transplantations and 1 retransplantation were performed in our center. Sixteen patients are alive, 5 beyond 2 years and 1 longer than 4 years after transplantation. The actuarial 1- and 2-year survival is 60%. Factors contributing to this result are patient selection and biliary anastomosis. In cirrhotic patients, the degree of deterioration of liver function correlated with survival; in patients with hepatocellular carcinoma, extrahepatic spread of tumor was the most frequent limiting factor. Choledochocholedochostomy with a widening plasty had a low complication rate providing that the arterial blood supply was undisturbed. Until now, HLA-matching has not contributed to the result of liver transplantation, although the effect for long-term survival is still unknown. The high survival rate and excellent quality of life of long-term survivors justify liver transplantation as treatment for otherwise noncurable liver diseases.

Adolescent↗

PubMedDate not supplied

Quantitation of minor red cell populations using the single-channel autoanalyzer.

An automated hemagglutination technique has been applied to the quantitation of the size of minor red cell populations. By choosing an antibody to an antigen present only on the minor population, it was possible to estimate the size of the minor population by measuring the antibody following incubation with the red cell mixture. The size was directly proportional to the amount of antibody consumed and was calculated from a regression plot established from standard mixtures. With this method, it was possible to detect minor red cell populations as dilute as 1:5000.

Autoanalysis↗

PubMedDate not supplied

Industrial hygiene in the pharmaceutical industry.

This chapter addresses primary and secondary manufacturing, exposure monitoring, engineering controls, and personal protective equipment in the pharmaceutical industry. Trends affecting industrial hygiene also are examined.

Drug Industry↗