The retention and distribution of radioactive mercuric oxide following accidental inhalation.
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Biomedical subjects
Publications and source records attributed to D Newton.
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Several indices of thyroid function were assessed in 74 patients with chronic renal failure. Sixty patients had undergone haemodialysis for varying periods. Within the first six months of haemodialysis treatment protein-bound iodine and total thyroxine (T4) levels rose, but after this T4 levels and the free thyroxine index fell progressively. Three out of the 12 patients who had undergone haemodialysis for longer than three years had subnormal T4 and supranormal thyrotrophin concentrations and a subnormal response to thyrotrophin stimulation. Lon-term haemodialysis may be a cause of biochemical hypothyroidism.
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Techniques of body radioactivity measurement were used to study the clearance of activated tantalum oxide accidentally inhaled by three reactor workers. The whole-body retention after 7 days was about 1% of the initial deposit. In one subject studied for a further 424 days the residual activity in the thorax was cleared with a biological half-life of about 1,400 days. The results support indications from other studies that tantalum powder administered in aerosol bronchography may be subject to prolonged alveolar retention.
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