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Biomedical subjects

D N Croft

Publications and source records attributed to D N Croft.

At least 73 records · Page 4Linked to original sources
PubMed1971

Diagnosis of established deep vein thrombosis with the 125 I fibrinogen uptake test.

One hundred and two patients with clinical signs indicating a possible diagnosis of deep vein thrombosis were studied with the fibrinogen uptake test and phlebography to assess the reliability of the test as a means of diagnosing established venous thrombosis. The test gave a correct diagnosis in 78% of the 85 legs shown to contain thrombus by phlebography and only 19 (10%) false-negative results in the 195 legs examined. The duration of the symptoms, the administration of anticoagulants, and mild leg swelling did not affect the accuracy of the test. Very old thrombus, phlebographically more than 11 days old, was associated with an increased false-negative rate.The fibrinogen uptake test is accurate enough to make it a valuable method of clinical investigation.

Adult↗
PubMed1971

131-I hippuran renogram in acute renal failure.

A hippuran renogram pattern of the type usually interpreted as indicating urinary tract obstruction was seen in acute tubular necrosis and was present both in the oliguric and in the diuretic phase. It seems that in acute renal failure the renogram does not distinguish urinary tract obstruction from intrinsic renal disease.

Acute Disease↗
PubMed1971

Protein loss and cell loss from the small-intestinal mucosa.

Total protein and deoxyribonucleic acid (dna) were measured in small-intestinal washings from rats with normal and high rates of dna (or cell) loss. There was a significant relationship between the loss of these two substances. Preparations of isolated viable epithelial cells contained much less protein in relation to dna than did the intestinal washings. It was calculated that only 8 to 15% of the protein lost by washing the rat small intestine arose from the intracellular protein of exfoliated epithelial cells. The rest was derived from extracellular sources.Protein and dna loss from small-bowel mucosa was measured in six patients. The ratio of protein to dna was similar to that found in the rats. The mean protein loss from 5 cm of human upper small intestine was 956 mug per min or 1.4 g per 24 hours. By calculation, total protein loss from the whole small intestine of man was about 84 g per day, about 10 g coming from within exfoliated cells and the rest arising from extracellular sources. The normal intestine must reabsorb most of this material.

Animals↗
PubMed1970

Cell loss from small intestinal mucosa: a morphological study.

Large numbers of cells are shed from small intestinal mucosa but they are so rapidly destroyed that there is little direct information about their morphological types. Material obtained by washing the human and rat small intestine was immediately processed and examined by light and electron microscopy. Small intestinal epithelial cells could not be identified by light microscopy but were readily recognized-by the presence of brush borders-using the electron microscope. Eighty to 85% of the cells from both rats and patients with normal small intestinal mucosa were intestinal absorptive cells. This was also the case in four patients with the coeliac syndrome and flat intestinal mucosa. These findings provide further support for the view that measurements of cell loss using intestinal washing techniques and the DNA-loss method, reflect predominantly small intestinal epithelial cell loss and turnover.

Animals↗