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Biomedical subjects

D Montgomery

Publications and source records attributed to D Montgomery.

107 records · Page 6Linked to original sources
PubMed1971

Differentiable pseudo-free circle actions.

The circle group G is said to act pseudofreely if it is not free and if every orbit is one-dimensional and if the isotropy group is the identity except on isolated exceptional orbits where the isotropy group is the finite cyclic group Z(k), k > 1. We consider differentiable actions of this kind on homotopy seven spheres and classify all such actions. As a corollary, it follows that there can be any finite number of exceptional orbits, in contrast to the linear case where there can be at most four.

Journal Article↗
PubMedDate not supplied

Impact of fat reduction on micronutrient density of children's diets: the CATCH Study.

BACKGROUND: The purpose of this study was to examine the impact of fat reduction on vitamin and mineral density in the diets of groups of children who participated in the CATCH school-based intervention study for 2 1/2 years. METHODS: Twenty-four-hour dietary recalls were collected on 1,182 children residing in four states and with diverse ethnic backgrounds, at baseline when they were in third grade and again at follow-up when they were in fifth grade. RESULTS: With a 2.4% reduction in total fat intake from baseline levels in the intervention group, mean changes in vitamin and mineral intakes per 1,000 kcal of this group were small yet significant compared with the control group. As mean fat intake decreased, the nutrient density of most vitamins and minerals increased; the sole exceptions were vitamin E and sodium. Mean intake of all vitamins and minerals studied exceeded 2/3 of the RDA at both baseline and follow- up for both the intervention and the control groups. No significant differences were noted between treatment groups for the percentages of children meeting 2/3 or more of the RDA at both baseline and follow-up periods. CONCLUSIONS: CATCH was successful in maintaining mean vitamin and mineral intakes of intervention group children when total dietary fat was reduced.

Adolescent↗
PubMedDate not supplied

The uptake of naturally occurring amino acids by the plasma membrane of the human placenta.

The characteristics of the uptake of four naturally occurring amino acids, alanine, leucine, lysine and aspartate, by microvesicles prepared from the plasma membrane on the maternal surface of the human placenta were studied. Electron microscopy showed that a variety of fragments was interspersed between the vesicles and this heterogeneity probably accounted for the considerable variation in the results. Nevertheless, the properties of the uptake of amino acids were similar to those of vesicle preparations from other tissues. Insulin did not enhance the uptake of any of the amino acids.

Alkaline Phosphatase↗
PubMedDate not supplied

Shaken baby syndrome: identification and prevention for nurse practitioners.

Shaken baby syndrome is a less widely recognized form of physical child abuse. It is defined as vigorous manual shaking of an infant who is being held by the extremities or shoulders, leading to whiplash-induced intracranial and intraocular bleeding and no external signs of head trauma; often identifying shaken baby syndrome is difficult because of the lack of obvious external signs. Shaken baby syndrome should be considered in infants with seizures, failure to thrive, vomiting associated with lethargy or drowsiness, respiratory irregularities, coma, or death. With the increased awareness of child abuse, more attention has been focused on morbidity and death caused by the violent shaking of infants. This article describes the clinical findings of shaken baby syndrome, explores the characteristics of families at risk for abuse, and discusses implications for nurse practitioners.

Child Abuse↗
PubMedDate not supplied

[Biological treatments in obsessive-compulsive disorder].

Obsessive-compulsive disorder (OCD) is emerging very clearly as a serotonin specific illness. The evidence for this comes from a variety of clinical sources. Firstly the efficacy of 5-HT uptake inhibitors, especially clomipramine, is consistent and strong. Secondly clomipramine has not merely been found to be effective against placebo in 9 placebo controlled studies, it is also found to be more effective in some studies than reference tricyclic antidepressants and monoamine oxidase inhibitors. In other studies tricyclic antidepressants do not appear to be better than placebo. The lack of efficacy of general antidepressants, neuroleptics and benzodiazepines supports the specificity of the serotonin effect. Thirdly the evidence of the efficacy of clomipramine in OCD without concomitant depression reported by Montgomery 1980 and supported by other studies suggests that 5-HT uptake inhibitors have a specifically anti-obsessional effect. The lack of response of depressive symptoms in OCD to other antidepressants suggests that these depressive symptoms are integral to OCD and will only respond when the OCD is treated. Many of the studies found efficacy for 5-HT uptake inhibitors compared with placebo despite both groups being treated with concomitant behaviour therapy. This argues either for behaviour therapy being relatively ineffective or for there being a synergistic effect with the 5-HT uptake inhibitor which is more likely. Results from studies with selective serotonergic probes with a worsening of OCD symptoms in response to the 5-HT1A agonist, m-chlorophenyl piperazine, add support to the serotonergic hypothesis of OCD but further investigation is needed.

Antidepressive Agents, Tricyclic↗