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Biomedical subjects

D Michel

Publications and source records attributed to D Michel.

At least 163 records · Page 9Linked to original sources
PubMed1990

[Cortical pain. Clinical, electrophysiologic and topographic study of 12 cases].

Vascular lesions of the cerebral cortex sparing the thalamus (MRI or CT with reconstructions) may be accompanied by burning or constrictive pain which suggests thalamic pain as it affects one half of the body and is associated with induced pain. Summation hyperpathia is rare; allodynia is more common and sometimes isolated (2 cases). Cortical pain may be paroxysmal, and in 3 of our patients it progressed like a jacksonian seizure. The territory of pain is also the site of global or spinothalamic hypoaesthesia (5 cases). Early SEPs are abolished or of low amplitude (8 cases). The lesion is located in area SI or extends to the thalamo-parietal radiations; in 11 out of 12 patients it was located in the minor hemisphere. Two physiopathological theories are discussed: hyperactivity of the intralaminar thalamus relieved from cortical inhibition, or denervation hyperactivity related to the cortical or subcortical lesion.

Adult↗
PubMed1989

[Drug therapy of heart failure in the elderly].

In the case of heart failure of any etiology, so common in the elderly, symptomatic treatment predominates; causal therapy is hardly ever possible. The aim of treatment is to improve myocardial contractility and influence secondary compensation mechanisms which, although associated with a favorable effect in the early stage, in the late stage lead to an unacceptable elevation of afterload and an overall uneconomical cardiac performance, thus producing a negative effect on cardiac failure and its prognosis. In contrast, suitable treatment improves the quality of the patient's life and prolongs life expectancy. In the aged, suitable therapy includes, where indicated, in particular digitalis (there is no alternative!), ACE-inhibitors and diuretics. The incidence and extent of adverse reactions and interactions in the elderly are greater than in the young and middle-aged patient.

Aged↗
PubMed1989

[Anomalies in early somatosensory evoked potentials in brain stem lesions (study of 64 cases)].

Short latency somatosensory evoked potentials (SEPs) have been recorded in 64 patients with brainstem lesions documented by neuroimaging techniques. Patients were classified in four groups according to the lesion topography: cervico-medullary junction and medulla (16 cases), pons (19 cases), mesencephalon (8 cases), extensive (21 cases). SEPs were abnormal in 57.8% of cases either bilaterally (17.2%), or unilaterally (40.6%). The different components were affected as follows, P14: 34.4%; N20: 56.9%; P22 and N30: 54.7%, peripheral and spinal responses were always spared: N18 and P14 abnormalities were highly correlated. In cervico-medullary lesions P14 and N20 were constantly abnormal, P14 was normal in strictly mesencephalic lesions but could be abnormal in cases of subthalamic lesions with mesencephalic extension; in pontic lesions, P14 could be normal or not, and N20 was always very reduced. These results confirm that P14 has a supra-spinal origin and may have two generators. SEPs detected a subclinical dysfunction of the lemniscal pathways in 18% of patients with normal somatosensory performances and, as BAEPs (abnormal in 54% of the 54 recordings performed in this series) deserve to be recorded for the routine investigation of brainstem function.

Adolescent↗
PubMed1989

Expression of a novel gene encoding a 51.5 kD precursor protein is induced by different retroviral oncogenes in quail neuroretinal cells.

A cDNA clone, named T64, was isolated from a library of quail neuroretinal cells transformed by a thermosensitive v-src mutant of Rous sarcoma virus. it corresponds to the most abundant mRNA with thermodependent expression in these cells. T64 accumulation also correlated with pp60v-src activity in other cell types transformed by RSV, such as fibroblasts and myoblasts, but was independent of the proliferative state of the cells, indicating that T64 is rather implicated in the process of morphological transformation. Nuclear run on experiments showed that the accumulation of T64 mRNA in transformed neuroretinal cells is the consequence of an increased transcription rate. Enhancement of T64 expression on QNR cells was also achieved by infection with avian retroviruses harboring other oncogenes with protein kinase activity such as v-fps and v-mil. The 1.6 kb T64 mRNA was detected in vivo in a few quail tissues at levels 50-200-fold lower than in RSV-infected cells. DNA sequencing of the T64 cDNA revealed an open reading frame encoding a 449 amino acids protein with a typical N-terminal signal peptide and with significant amino acid sequence homology with a rat-secreted protein.

Amino Acid Sequence↗
PubMed1989

[Eye manifestations of Horton's disease].

Ocular complications occurring in temporal arteritis are of different severities. These manifestations of the disease occurred in a population of 57 patients with diagnosis of temporal arteritis, in 16 of them (28%). The diagnosis was suggested by finding an inflammatory syndrome (high erythrocyte sedimentation rate) and confirmed by temporal artery biopsy. In making this diagnosis, it was helpful to find a history of characteristic temporal headaches, neckache, jaw claudication, fever and malaise or weight loss in addition to polymyalgia and polyarthralgia. 6 patients presented with diplopia and different ocular muscle or nerve palsies. The 10 others came for sudden loss of vision due to ischemic anterior or posterior neuropathy and in one case, central artery obliteration. Prompt treatment with steroids gave good results on oculomotor troubles and in preventing the risk of involvement of the fellow eye. But loss of vision did not regress with this treatment. That means the importance in making this diagnosis and starting very promptly this treatment.

Blepharoptosis↗
PubMed1989

[Chronic peripheral neuropathies with corticosensitive heredodegenerative aspects: 2 cases].

Two cases of peripheral neuropathy beginning in childhood are reported. Both had features suggestive of HMSN with pes cavus and kyphoscoliosis. Familial history of HMSN type I was present in 9 members of the kinship in case 1. In case 2, a mild neuropathy without pes cavus was present in the father. Case 1 developed four relapses of ascending sensory-motor deficit with conduction blocks suggestive of a superimposed chronic inflammatory polyneuropathy (CIP) which improved under prednisone. In case 2, the course was progressive with a severe proximal and distal motor weakness and sensitive disturbances. CSF protein concentration was high. Nerve biopsy showed rare onion bulbs and intense demyelination. These results joint to the unspecificity of the father's neuropathy are consistent with a probable childhood. CIP which improved under prednisone. These two cases indicated that in some patients with unusual symptoms for HMSN, prednisone should be considered and that the physiopathology of these neuropathies is probably heterogeneous.

Child↗
PubMed1989

[Antifungal effects in vitro of jasmon and some similar compounds. Structure-activity relationship].

The antimycotic activity in vitro of jasmon and 6 closely related substances has been tested against four different dermatophytes, Candida albicans, Pityrosporum ovale and Aspergillus fumigatus. Jasmon had the highest activity. Among the other substances tested only thiazolidines with a carbonyl function developed antifungal properties against dermatophytes. 2,4 thiazolidinedione at 450 ppm inhibits the growth of Trichophyton rubrum.

Antifungal Agents↗