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Biomedical subjects

D Michel

Publications and source records attributed to D Michel.

At least 181 records · Page 10Linked to original sources
PubMed1988

[Dissecting aneurysm of the intracranial vertebral artery. An anatomo-clinical case].

A 64 year old patient with a cardiac prosthesis and receiving antivitamin K therapy presented with a right bulbar syndrome. Based on absence of meningeal signs and hemorrhage on CT scan heparin therapy was instituted. Fatal coma developed two and a half days later. Autopsy findings included a right lateral bulbar infarct and meningeal hemorrhage, predominant around a fusiform dilatation of the end of the right vertebral artery. Serial sections showed a large dissecting aneurysm between media and adventitia communicating with an intimal tear. Among intracranial dissecting aneurysms those of vertebrobasilar localization have the peculiarity of being subadventitial in some cases, with a subsequent enhanced risk of hemorrhagic complications. The use of anticoagulants appears contraindicated in these cases, even if their clinical expression is suggestive of an infarct. Their etiology is often unknown.

Aortic Dissection↗
PubMed1987

[Proarrhythmia].

Explore the source record for details and available documents.

Anti-Arrhythmia Agents↗
PubMed1987

Arrhythmogenic potential of exercise-induced myocardial ischaemia.

In a series of 300 patients following transmural infarction undergoing coronary angiography because of ischaemia in the surviving myocardium, 17 demonstrated an exercise response indicative of myocardial ischaemia in the absence of angina pectoris. The presence of ischaemia in the region of the myocardium under scrutiny was proven by: (1) ST-segment depression during bicycle-ergometry of at least 2 mm in leads without any QRS or ST-T changes at rest. (2) greater than 75% stenosis of vessels supplying the area under investigation, in addition to the vessel supplying the region of the infarction. (3) A reversible Thallium-perfusion defect on exercise. We compared those 17 patients with silent myocardial ischaemia with 21 patients with typical angina pectoris on exertion. All patients underwent 24-hour Holter monitoring, treadmill exercise testing at a target heart rate previously determined as inducing signs of myocardial ischaemia, and swimming and calisthenic programs with telemetric ECG recording. There was no close relationship between myocardial ischaemia and the occurrence of complex ventricular arrhythmias. In silent ischaemia complex ventricular arrhythmias do not occur at a higher rate than in patients with angina pectoris.

Angina Pectoris↗
PubMed1986

[X-ray computed tomography in central pontine myelinolysis. 2 cases].

Two cases of central pontine myelinolysis were studied by computerized tomography (CT). One patient had chronic alcoholism, the other porphyria variegata; both initially presented with water-and-electrolyte disorders, notably hyponatraemia. The neurological disorders consisted of acute pseudobulbar syndrome which totally regressed within 15 days to 1 month. CT demonstrated a low density area in the pons, extending to the mesencephalon in one case. Despite clinical cure, this low density persisted for 16 and 20 months respectively, counting from the onset of neurological symptoms. In central pontine myelinolysis, CT images only are of diagnostic value in cases with suggestive neurological symptoms and aetiology. CT can recognize minor forms of the disease and confirms that in some cases severe forms may follow a regressive course.

Adult↗
PubMed1986

Cerebrospinal fluid and serum immune complex in acute inflammatory polyneuritis. Detection by Clq binding assay.

Immune complexes (IC) were assessed in serum and CSF from 11 patients with acute inflammatory polyneuritis (AIP). An 125 I-labeled Clq binding assay (Clq BA) was used. IC were present in the sera of four patients and in the CSF of six. CSF-Clq BA of AIP (Group 1) were compared with 12 patients with other inflammatory neurological diseases (Group 2) and 22 patients with non-inflammatory neurological diseases (Group 3). There was only a significant difference between Group 1 compared to Group 3 (p less than 0.05). Serum and CSF IC did not correlate either with blood-brain barrier lesions or with immunoglobulin deposits in sural nerve biopsy.

Acute Disease↗
PubMed1986

[Dural arteriovenous fistulas of the posterior cerebral fossa and thrombosis of the lateral sinus. Discussion of their relations and treatment apropos of 2 cases].

Two cases of a posterior fossa dural arteriovenous malformation associated with a lateral sinus thrombosis are reported. In the first case, a right tentorial meningioma develops at the end of the superior sagittal sinus and on the transverse sinus which are occluded. A cranial bruit, heard by the patient four months after the surgical removal of the tumour, brings up a dural fistula supplied by the occipital, middle meningeal and pharyngeal arteries and drained away by cervical and cortical veins. Many attempts of extirpation and radiological embolization stop the bruit. In the second case, an increased intracranial pressure mixes up with an aphasia. A continuous emission doppler examination and a CT scan make likely a dural fistula. The malformation, which is associated to a left sigmoid sinus thrombosis, is fed by the occipital and middle meningeal arteries and drained by cortical veins to the cavernous sinus. The occipital artery ligation and a by-pass between the lateral sinus and the internal jugular vein cure the patient with a very good patency of the venous graft that holds up two years after. A few cases of the literature show the succession of the two vascular lesions and prove the primitive occurrence, either of the sinus occlusion, or of the dural fistula. A venous thrombosis might cause a fistula by the opening of physiological shunts of the dura-mater which consequently deviates the blood into the cortical veins, brings down the increased intracranial pressure and stops the thrombosis to spread.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Lymphocyte subpopulations of the blood and cerebrospinal fluid in acute polyradiculoneuritis. Study of 14 cases using monoclonal antibodies].

The T lymphocytes in blood and CSF of 14 patients with acute polyradiculoneuritis were studied using the OKT series of monoclonal antibodies. Results were compared with findings in two control groups. Three patients with cytomegalovirus infection showed elevation of circulating OKT 8. A significant increase in the mean ratio OKT 4/OKT 8 was noted in all other cases, corresponding in 4 of the 11 patients to a reduction in number of OKT 8 lymphocytes. The CSF was normal in 3 of the 14 cases.

Acute Disease↗