Blindness in South Hampshire sheep: a neuronal ceroidlipofuscinosis.
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Animals↗
Biomedical subjects
D M West
Publications and source records attributed to D M West.
Biologic characteristics of transformed rhesus foreskin cells infected with Mason-Pfizer monkey virus.
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Animals↗
Virus susceptibility of a new simian cell line of fetal origin.
The cultivation and characterization of a cell line derived from the foreskin of a fetal, rhesus monkey (rhfs2) are described. This cell line has proven satisfactory for isolation and assay of a variety of viral agents of human and simian origin. Virus titrations performed on foreskin cells yielded titers comparable to, or higher than, those obtained in rhesus monkey kidney cells (LLC-MK2). Replicate isolation attempts in our laboratory from simian clinical specimens have proven rhfs2 superior to LLC-MK2 for ease of detection and frequency of isolation.
Adenoviridae↗
A coding system for reporting treatment services.
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Electronic Data Processing↗
Ovine ceroid-lipofuscinosis: a model of Batten's disease.
An inherited neurological disease of sheep was characterized by the intracellular accumulation of autofluorescent lipopigments in neurones and a wide variety of other cells within the body. The staining, fluorescent, ultrastructural and physical characteristics of the storage material were similar to those found in a heterogeneous group of storage diseases of children known as Batten's disease or the ceroid-lipofuscinoses. The ovine disease did not exactly fit any of the main human entities, but had features in common with both the late infantile and juvenile forms. It was concluded that this was a useful model for studying the pathogenesis of this type of storage disease and for therapeutic trials. A flock of sheep is maintained for this purpose.
Animals↗