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Biomedical subjects

D M Walker

Publications and source records attributed to D M Walker.

At least 145 records · Page 8Linked to original sources
PubMed1975

A trial of cromoglycic acid in recurrent aphthous ulceration.

In a random double blind trial with crossover on 24 patients with recurrent aphthous ulcers (RAU) cromoglycic acid tablets significantly reduced the pain experienced when compared with placebo but did not reduce the number of days with oral ulceration present. Of the 15 patients completing the trial, 12 preferred CGA to placebo, two preferred the placebo and one had no preference. It is concluded that the cromoglycate compounds may have a valuable part to play in the symptomatic relief of RAU.

Administration, Oral↗
PubMed1975

Effect of disodium cromoglycate on lymphocyte response to antigen and mitogen.

The effect of disodium cromoglycate (DSCG) on the three following in vitro correlates of cell-mediated immunity has been studied: (1) Transformation of human peripheral blood lymphocytes after stimulation by an antigen, purified protein derivative and a mitogen, phytohaemagglutinin; (2) release of macrophage migration inhibitory factor, and (3) cytotoxic factor production, from these stimulated lymphocytes. At two non-toxic concentrations DSCG did not inhibit these three lymphocyte functions. These results suggest that DSCG's clinical effectiveness does not depend upon modulating cell-mediated immune response. The implications of these findings in relation to present concepts of the cellular action of DSCG and the intracellular control of the initiation of lymphocyte transformation are discussed.

Adult↗