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Biomedical subjects

D M Walker

Publications and source records attributed to D M Walker.

At least 127 records · Page 7Linked to original sources
PubMed1980

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

An imprint culture technique has been employed to study the prevalence and intraoral distribution of Candida albicans in 16 patients with Sjögren's syndrome and in 16 healthy controls matched for age, sex, and dental status. The prevalence and intraoral density of C. albicans was found to be significantly higher at almost all sites in the Sjögren's patients than in the controls. The distribution of candida was also altered, being significantly higher in the floor of the mouth and anterior labial sulcus in the Sjögren's group. There was an approximate inverse relationship between candida populations and rate of salivary flow. Mean candida densities were found to be significantly higher in those Sjögren's patients with detectable serum rheumatoid factor in the serum. However, patients with primary Sjögren's syndrome had significantly higher mean candida densities compared with patients with secondary Sjögren's syndrome.

Adult↗
PubMed1978

Amino acid supplementation of isolated soybean protein in milk replacers for preruminant lambs.

The growth of preruminant calves and lambs fed on milk replacers containing vegetable proteins is generally inferior to that of preruminants given cows' milk. The inferior performance has variously been attributed to an amino acid imbalance, to heat damage in preparation, and to the presence of growth-retarding substances. Soybean products that have been treated to remove, or destroy, growth-retarding substances are now available commercially. An experimental design is described that has been used to determine the order of limiting amino acids in soy protein isolates, and which may also be used to estimate requirements for individual amino acids. The design allows an economy in time and in experimental animals, and gives results that are not significantly different from those determined in classical balance experiments.

Amino Acids↗
PubMed1978

Anterolateral rotatory instability of the knee joint. An early analysis of the Ellison procedure.

Our experience with the Ellison procedure for the control of anterior subluxation of the lateral tibial plateau includes fifty-two knees in which we used this procedure either alone or in combination with other reconstructive procedures. The results directly attributable to the Ellison procedure itself after follow-ups of six months or more could be evaluated in fifteen patients who had only the Ellison procedure for anterolateral instability and in thirteen who had both this procedure and a pes anserinus transfer for combined anterolateral and anteromedial instability. Of the twenty-eight patients so evaluated, only sixteen (57 per cent) had good or excellent results. The pivot-shift phenomenon, present in all twenty-eight knees preoperatively, had been eliminated in only four at follow-up. A positive anterior drawer sign was present in all patients both before operation and at follow-up. The subjective and functional improvement did not correlate well with the clinical and roentgenographic findings. From this study it is our impression that the results of this operation are disappointing and that it should be used only as an adjunctive procedure in lateral reconstruction in young patients.

Adolescent↗
PubMed1977

HL-A histocompatibility antigens in recurrent aphthous ulceration.

The frequency of HL-A phenotypes has been investigated in 64 patients who had recurrent aphthous ulcers and 100 subjects who did not. The HL-A phenotypes were determined by a two-step microcytotoxicity test on peripheral blood lymphocytes, incubating these cells with a range of defined antiserums and complement and subsequently assessing lymphocyte viability by dye exclusion. There were no significant differences between the frequency of individual HL-A antigens in the patients with aphthous ulceration and those of subjects without aphthous ulceration. Similarly, no differences in numbers of shared antigens could be demonstrated. The distribution of HL-A antigens was essentially similar in subdivisions of patients with aphthous ulceration, grouped on the basis of sex, family history, age at onset, and maximum number of concurrent ulcers and their duration before healing.

Cytotoxicity Tests, Immunologic↗
PubMed1976

Application of trihydroxyindole reaction to methanesulfonanilides: fluorometric analysis for soterenol and mesuprine.

Methanesulfonanilides, like soterenol and mesuprine, which are bioisosteric with adrenergic catecholamines, form fluorescent species when subjected to the trihydroxyindole reaction. Presumably, the fluorescence is due to adrenolutin-like species formed from aminochrome intermediates. Fluorescence was not induced in a relative of soterenol where a methyl group was added to the sulfonamido nitrogen, a fact that suggests the presence of a quinoid intermediate in the reaction scheme of soterenol. A ring isomer of soterenol, where the methanesulfonamido and hydroxyl groups were interchanged, produced only about 5% as much fluorescence response as soterenol. The sterenol counterparts to isoproterenol and isoproterenol sulfonic acid did not produce fluorescence when treated like soterenol. This finding and the fact that response was linear with concentration for soterenol and mesuprine suggest that a fluorometric analysis could be developed for these methanesulfonanilides.

Anilides↗
PubMed1976

Identification of subpopulations of lymphocytes and macrophages in the infiltrate of lichen planus lesions of skin and oral mucosa.

The mononuclear cells of the infiltrate in lichen planus lesions of skin and oral mucosa have been identified by detection of their membrane receptors in frozen-tissue sections. By this method, the infiltrate would appear to consist of predominantly T lymphocytes, some macrophages and only a few B cells. The pathogenesis of lichen planus is discussed in the light of these findings.

B-Lymphocytes↗
PubMed1976

The periodontal management of a patient with a profound immunodeficiency disorder.

A case of severe, uncontrolled periodontal disease in a patient with a profound immunodeficiency disorder is reported. The periodontal disease was noted before the age of 10 years and is generalized, with marked associated alveolar bone loss, even threatening a mandibular fracture. Severely involved teeth were allowed to exfoliate, and extractions were avoided. At the age of 17 years, the patient now has only nine remaining teeth. The management adopted and alternative approaches are critically reviewed. The implications of the dental findings for current concepts of the pathogenesis of periodontal disease and dental caries are discussed.

Adolescent↗
PubMed1976

The inflammatory infiltrate in lichen planus lesions. An autoradiographic and ultrastructural study.

The labeling index of the infiltrate of oral lichen planus lesions was significantly greater than that of normal mucosa, and its labeling activity redistributed, as determined by in vitro autoradiography. An electron microscopic examination of the infiltrate of lichen planus lesions of oral mucosa and skin supported the concept that the lichen planus infiltrate represents a cell mediated immune response in which T lymphocytes and macrophages are predominant.

Adolescent↗