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Biomedical subjects

D M Jones

Publications and source records attributed to D M Jones.

At least 235 records · Page 13Linked to original sources
PubMed1981

Serological studies in two outbreaks of Campylobacter jejuni infection.

Two outbreaks of campylobacter enteritis in residential student populations are described. In the first outbreak, 34 of 240 students in one hall of residence became ill over the course of 4 or 5 days. A single serotype of C. jejuni was isolated from sample of faeces. Sera collected demonstrated that the students had little pre-existing antibody and antibody responses were demonstrated in those who were infected. About 30% of students with serological evidence for infection with C. jejuni did not have gastro-intestinal symptoms. In the second outbreak, 77 of 300 agricultural students developed symptoms over a period of 3 weeks. Unpasteurized milk was the source of infection. Two serotypes of C. jejuni were isolated from faeces. Antibody responses were detected to both these serotypes and to another serotype, suggesting the presence of at least 3 serotypes in the milk. Bactericidal antibody consistent with recent infection was found in all students with symptoms and in 63% of students in the absence of symptoms, indicating the possible development of immunity. The high prevalence of antibody in these students was correlated with the habitual consumption of unpasteurized milk.

Adult↗
PubMed1981

Plasma concentrations of oestradiol-17 beta and progesterone, and laparoscopic observations of the ovary in the puma (Felis concolor) during oestrus, pseudopregnancy and pregnancy.

Plasma levels of oestradiol and progesterone in 3 pumas during oestrus and artificially induced pregnancy and pseudopregnancy were determined by radioimmunoassay. During oestrus, basal levels of oestradiol (5-30 pg/ml) were interrupted by surges of 30-375 pg/ml at intervals of 17-25 days. Considerable variation occurred between and within animals. Periods of oestrus and follicular development were confirmed by laparoscopy and vaginal smear patterns. Absence of an increase in plasma progesterone following elevated levels of oestradiol and failure to observe corpora lutea in the ovary indicated that ovulation was probably not spontaneous. Plasma oestradiol values rose dramatically in response to PMSG but were low during pseudopregnancy until the return to oestrus. During pregnancy surges of oestradiol occurred at mid-term and immediately before parturition. Ovulation, confirmed by laparoscopy, occurred 24-48 h after hCG and progesterone levels (usually less than 2 ng/ml) then increased to reach 150-300 ng/ml on Days 24-28. In the pseudopregnant animals progesterone concentrations had returned to baseline by Days 45-50 but during pregnancy progesterone remained elevated, declining only gradually to basal values by Day 85. A minor peak of progesterone, coincident with the pre-partum oestradiol surge, occurred on Day 87, 1 week before parturition on Day 95.

Animals↗
PubMed1980

Ivory tower psychiatry.

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Community Mental Health Services↗
PubMed1980

Effects of structured relaxation on retrieval from long term storage: an EMG study.

The effects of 20 min structured relaxation immediately prior to retrieval were observed for word lists learned 48 hours previously. Error probabilities and response latencies were scored at acquisition and retrieval for paired associates at two levels of response dominance. Frontalis isometric muscles tension was measured just prior to and during retrieval. Relaxation markedly reduced EMG activity associated with muscle tension. This effect did not extend to the retrieval period. Error probabilities were significantly lower for retrieval preceded by relaxation but the interaction between relaxation and response dominance proved non-significant. These findings suggest that states of low arousal do not bias memory search to readily accessible information as appears to be the case for high arousal.

Electromyography↗
PubMed1980

Antimicrobial susceptibilities of Clostridium difficile.

The antimicrobial susceptibilities of 78 strains of Clostridium difficile isolated from patients with and without gastrointestinal symptoms were determined and compared. Strains from patients with symptoms were more likely to show resistance to antibiotics. The antimicrobial susceptibilities of toxigenic and non-toxigenic strains were found to be similar.

Adult↗
PubMed1980

Serotyping of Campylobacter jejuni/coli.

Antisera were prepared from strains of Campylobacter jejuni/coli isolated from patients in six outbreaks of enteritis. Bactericidal antibodies, and agglutinating antibodies to heat-labile and heat-stable antigens, were demonstrated. These reactions were used to type a number of strains isolated from patients in each outbreak, and to distinguish 'epidemic' from 'non-epidemic' strains.

Campylobacter↗
PubMed1980

Serological response to Campylobacter jejuni/coli infection.

The antibody response to Campylobacter jejuni/coli infection was investigated in 59 patients involved in two outbreaks of milk-borne infection and in sporadic infections in the community. Agglutinins and complement-fixing (CF) antibodies were detected in nearly all these patients. Agglutinins were present in 25% of normal sera at low titres (not greater than 1/160) but CF antibody titres of 1/4 or 1/8 were present in only 2.0%. The agglutination reactions in convalescent sera were best developed with the homologous or an antigenically similar strain whereas the CF test, with sonicated organisms as antigen, was less strain-specific and was more suitable as a routine test. Antibody was present seven to 10 days after the onset of symptoms.

Agglutination Tests↗
PubMed1980

Interstitial cell tumour of the testis in a western lowland gorilla (Gorilla gorilla gorilla).

The post mortem in an adult male gorilla (Gorilla gorilla gorilla) aged approximately 33 years revealed very small testes, and the cut surface of the left testis appeared nodular. Microscopic examination showed a marked atrophy of seminiferous tubules and fibrosis together with a diffuse interstitial cell hyperplasia. Two interstitial cell adenomas were identified in the left testis.

Animals↗
PubMed1980

Recurrent meningococcal infections associated with a functional deficiency of the C8 component of human complement.

A patient is described who had a functional deficiency of the C8 complement component. His serum contained abnormal C8 which lacked some of the antigenic determinants of normal C8. The defect was associated with recurrent meningococcal infections due at different times to at least two strains. The patient's serum contained antibodies to meningococci and could induce phagocytosis and intracellular killing of the cocci by polymorphs. However, the serum was bactericidal only after the addition of C8-containing serum. As the patient did not give a history of susceptibility to other pyogenic organisms and has normal polymorph function, the circumstances of meningococcal infection must be unusual in that the plasma bactericidal activity critically determines the outcome: it may be that if large numbers of meningococci are not killed in the plasma, the polymorphs are overwhelmed.

Adolescent↗