Search PubMed⌕ Search

Biomedical subjects

D M Davis

Publications and source records attributed to D M Davis.

At least 91 records · Page 5Linked to original sources

Fourier-transformed infrared photoacoustic spectroscopy of biological materials.

A new technique for measuring the infrared spectra of solids has been developed. The photoacoustic spectra of hemin, hemoglobin, protoporphyrin IX, and horseradish peroxidase show how this technique can be used to obtain structural information about biological materials which cannot readily be studied by normal transmission infrared spectroscopy. The method requires milligram quantities of material and involves no sample preparation.

Fourier Analysis↗

Follow-up of adolescent psychiatric inpatients.

Psychiatric hospital services for adolescents have steadily increased in recent years and great interest has been generated in determining treatment outcome. In this study, 74 adolescent inpatients completed structured telephone interviews one year after discharge. The questions probed school, job, and family adjustment, as well as drug and alcohol use, participation in treatment, and legal problems. At the time of discharge, they had undergone objective, standardized psychologic tests including personally, locus of control, and parent-adolescent communication assessments. Statistically, the discharge locus of control test correlated with several areas studied. The more external the locus of control at discharge, the greater the likelihood of poor peer relations, poor family relations, and poor job adjustment at one-year follow-up. The discharge personality alienation scale was found to correlate inversely to school adjustment one year later. High emotional discomfort shown by the personality test was associated with increased likelihood of being in treatment at follow-up. Finally, a statistical profile of the adolescents one year after discharge is presented.

Adolescent↗

Sexual therapy for patients without partners.

Most available therapies for sexual dysfunction require a cooperative partner. This article describes a combined behavioral psychodynamic treatment program for sexual problems in people without partners. The method allows for flexibility in treating patients with widely varying personalities and levels of psychopathology.

Adult↗

Evaluation of nocturnal penile tumescence in the differential diagnosis of sexual impotence. A quantitative study.

Nocturnal penile tumescence (NPT) was assessed in 30 impotent patients for the purpose of differential diagnosis. In 11 psychogenic cases, with several exceptions, NPT was found to be normal, with a marked discrepancy between the NPT findings and the patients' estimates of their daytime erectile capacity. In 19 organic patients, maximal NPT corresponded closely to and mirrored the patient's subjective estimate of his impaired waking performance. Statistically, the figures for frequency, degree, duration, and amount of NPT were found to be significantly and markedly greater in the psychogenic group. Statistical significance was maintained when the 11 psychogenic patients were closely age-matched with 11 of the 19 organic cases. The method is not 100% accurate; some 15% of impotent patients without organic findings have reduced NPT, several of whom were shown to be psychogenic, but others in this group may have undetected organic pathology. The NPT method is very promising, but beset by a number of methodological problems.

Adult↗

Nickel gas chromatographic columns: an alternative to glass for biological samples.

Nickel tubing may be substituted for glass in the fabrication of gas chromatographic columns for use with samples of biological interest. Comparisons of separations of mixtures of steroids, narcotic alkaloids, phenothiazines, and amphetamines on stainless stell, glass, and nickel packed columns showed little or no observable sample decomposition on glass or nickel as contrasted to complete loss of certain compounds on stainless steel. The nickel columns are easily prepared, durable, economical, and not subject to breakage.

Alkaloids↗

Luteinizing hormone and testosterone during nocturnal sleep: relation to penile tumescent cycles.

Variations of plasma LH and testosterone in relation to sleep-related penile tumescence were assessed. Plasma LH and testosterone were measured at 10-20 min intervals in five normal adult men during 2 nights of sleep. Blood samples were obtained by means of an indwelling venous catheter while sleep was monitored polygraphically and penile tumescence recorded with a penile mercury strain gauge. Tumescent episodes were recorded in all subjects during 9 of the 10 nights of the study, and the percentage of time during sleep, which was associated with tumescence, ranged from 13% to 34%. Simultaneous REM and tumescence comprised 57.7% of total tumescent time. Abrupt elevations of plasma LH and testosterone were observed during the night without a significant relationship to stages of sleep. The mean of all hormonal determinations for the five subjects did not show significant differences in plasma LH and testosterone between fully and partially tumescent episodes and nontumescent periods. Mean testosterone during REM sleep with tumescence, a state of autonomic activation involving sexual function, was consistently higher for the five subjects than during periods free from REM and tumescence.

Adult↗

Use of a crisis committee in a therapeutic community.

Described is the use of a patient crisis committee in an adult therapeutic community. The crisis committee is a function of the patient government and is called into action in situations formerly handled by physicians or nurses. This method appears to be highly successful in the therapeutic community described.

Humans↗

An implementation of therapeutic community in a private mental health center.

The concepts of milieu therapy have, in the past 20 years, been widely applied to various facilities for treatment of people with emotional and mental illness. One type of milieu therapy, the Therapeutic Community, has gained increasing acceptance, as a means of implementing milieu therapy. This paper describes the application of therapeutic community concepts to the in-hospital population of a private, open-staffed, open-door psychiatric facility, and some of the effects that this has had on both the staff, and the patient population. Since the development of the therapeutic community concept almost 25 years ago, programs have been developed in various centers which implement the concepts of social psychiatry in different ways. This paper describes the development of a particular therapeutic community on the in-patient adult and adolescent psychiatric services of a private psychiatric hospital. Parkwood was developed as a small (40 bed) psychiatric hospital in Atlanta, Georgia in 1966 by a group of physicians wanting to implement the ideas of milieu therapy in an area where no such program was available. In its initial stages, the hospital -- of attractive, middle-class decor -- was built in a wooded setting on the edge of a large metropolis. It was open-staffed, with psychiatrists having an eclectic, though psychoanalytically based, orientation toward treatment. The concepts of milieu therapy were interpreted to mean the following: a warm, pleasant atmosphere, in pleasant surroundings, conducive to the usual brief psychotherapy, chemotherapy, or somatic therapy, which had previously been used in non-milieu psychiatric hospitals. The total hospital patient population was divided in half and met in group sessions with a psychiatrist once each week. The Medical Director, a psychiatrist, had weekly staff meetings, in which he discussed various administrative problems. In 1969, a Medical Director with a therapeutic community orientation was employed. Over a five-year period, the total complexion of the hospital changed to its present state, an open-staffed, open door, comprehensive, community mental health center financed on a private basis. The facility now provides out-patient, partial or total hospitalization, emergency services, and community education for children, adolescents, adults and alcohol addicted patients. This paper deals with the therapeutic community on the adult and adolescent units.

Adolescent↗

Dystonic reactions following neuroleptics: time course and proposed mechanisms.

The occurrence of acute dystonic reactions was studied relative to drug pharmacokinetic parameters following a single dose of the phenothiazine, butaperazine. Dystonias occurred more than one half-life from peak butaperazine levels, 23 to 56 h after drug administration. The authors postulate that the appearance of dystonias on falling plasma concentrations may be due to disruption of dopaminergic-cholinergic balance caused by differential antidopaminergic and anticholinergic potencies of the drug.

Acetylcholine↗

The assessment of nocturnal REM erection in the differential diagnosis of sexual impotence.

A new method for differentiating psychogenic from organic cases of sexual impotence is described based on the assesst of nocturnal REM erection in nine patients. It is our tentative impression that in psychogenic impotence nocturnal REM erection may be normal in amount and degree and an excellent indicator of erectile potential. In these cases a marked discrepancy exists between the amount and degree of nocturnal erection and the patient's daytime performance level attained during attempted coitus or masturbation. In the organic patients, on the contrary, such a discrepancy does not exist; instead, the maximal nocturnal erection attained corresponds closely to and mirrors the patient's impaired waking performance. This new method may be very useful in the diagnosis, prognosis, and decision as to type of treatment, especially in difficult cases.

Adult↗