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Biomedical subjects

D Lubach

Publications and source records attributed to D Lubach.

100 records · Page 6Linked to original sources
PubMedDate not supplied

The possible role of the initial lymph vessels of the skin during metastasis of malignant tumors.

The metastasizing potential of a malignant tumor is derived primarily from its biological characteristics. The second most important factor in metastatic spreading lies in the host tissue/organ and host metabolism. The aggressiveness of a malignant skin melanoma depends clinically upon the width and, especially, the depth of the preceding lesions(s). Histological and electron microscopic studies reveal that the increase of malignant aggressiveness is directly related to the arrangement of the initial lymphatic vessels in the different layers of the skin. Sudden increase in the density of lymphatic vessels permits a corresponding increment of malignant seeding via the lymphatic system.

Humans↗
PubMedDate not supplied

[Development and regression of dermal corticosteroid atrophy. 1. Change in the skinfold thickness].

We developed a method to test how quickly conventional corticosteroid ointments produce a reduction of dermal thickness and how rapidly this remits. This method is based on a measurement instrument which forms a fold from a 9 mm wide area of skin and continuously compresses it. The skin fold thickness (SFT) can be calculated from the compression plot, whereas the rate of compression (CR) can be taken as a measure of the mechanical behavior of the dermis. Clobetasol-17-propionate, betamethanone-17-valerate, diflorasone-17,21-diacetate, triamcinolane acetonide, hydrocortisone (in 10% urea), hydrocortisone butyrate and a mixture of clocortolone-21-pivalate and clocortolone-21-hexynoate were tested. The steroid products were applied under occlusive conditions for 17 d (for about 10 h during the night). Apart from hydrocortisone, the steroids led to a significant reduction in skin thickness within 6 to 10 d. After the end of the 17 d test, skin thickness returned to normal within 6 to 10 d. Non-steroidal control ointments, tested in the same way, caused a slight increase in thickness of the skin.

Administration, Topical↗
PubMedDate not supplied

[Development and regression of dermal corticosteroid atrophy. 3. Results of discontinuous topical corticosteroid administration].

It was shown in two earlier communications that a reduction in skin thickness owing to daily topical corticosteroid application (under occlusion) for about 12 h was measurable within a few days. Dermal atrophy remitted within one week. In this study, an open mode of topical application with a 0.1% triamcinolone ointment (Tri) once a day was tested. A decrease in thickness was also registered in the first week under this treatment. The following non-continuous modes of application were tested in 5 test subjects: 7 d Tri, 7 d free of treatment (7:) and 3 d Tri, 4 d free of treatment (3:4). In the 7:7 mode of application, there was a marked decrease of skin thickness during Tri application which remitted in the treatment-free interval. In the 3:4 application, almost no dependence on the individual phases could be discerned. Skin thickness decreased for nearly 16 d and began to normalize despite continued interval administration. At the end of the investigation (6 weeks), the skin had almost regained its original thickness.

Administration, Topical↗
PubMedDate not supplied

[Trace elements in samples of brittle and nonbrittle finger nails].

We examined nail samples of 27 adult patients suffering from brittle nails and 15 persons without nail disorders with respect to the content of trace elements. The analysis by atomic absorption spectroscopy disclosed the following values. In parentheses values of healthy nails. Ca 44.9 ppm +/- 25.0 (53.6 ppm +/- 22.5), Mg 182.4 ppm +/- 128.0 (183.1 ppm +/- 83.2), Al 25.6 ppm +/- 10.3 (33.0 ppm +/- 20.5), Cu 7.9 ppm +/- 3.0 (7.9 ppm +/- 2.7), Zn 80.9 ppm +/- 34.5 (85.0 ppm +/- 34.9), Fe 53.9 ppm +/- 24.5 (45.7 ppm +/- 24.4). Comparing the two groups no significant differences could be found.

Female↗
PubMedDate not supplied

[Development and regression of dermal corticosteroid atrophy. 2. Changes in compression rate].

In the 1st comm. results on development and remission of steroid-induced dermal atrophy were presented. Measurements were carried out with an instrument we constructed ourselves. This device enabled calculation of the rate of compression (CR) of a skin fold as well as determination of skin fold thickness (SFT). CR is specified in mm/log t. It is postulated that the CR depends on the viscosity of the basic substance and on the density of the collagen fiber skeletons led to an increase of SFT and CR. Loss of basic substance in quantitatively unchanged collagen skeletons led to a reduction of SFT and CR. In skin areas treated with corticosteroids, CR was reduced at roughly the same time as SFT. With the exception of hydrocortisone, the reduction was observed from about the 5th to the 10th d onwards in all products tested and became most pronounced after the 12th d. Following the end of steroid treatment (17th d), CR normalized within 6 to 10 d. It is concluded from the results that early steroid-induced dermal atrophy is caused by a lowering of the water/basic substance system. A steroid-specific inhibition of hyaluronic acid and glycosamine synthesis by the fibroblasts is assumed to be the cause of thickness loss. Skin areas treated with control ointments free of active substance displayed signs of increased hydratation.

Adrenal Cortex Hormones↗
PubMedDate not supplied

The role of dendritic cells in the motility of melanoma cells in initial lymphatic metastasis.

Malignant melanoma is well known for its aggressive metastatic behavior, following upon the earliest initial stages. It is the purpose of this preliminary paper to add some new ideas, based on electron microscopy, to our understanding of the complex progression of malignant melanoma, using cutaneous melanoma as a model for the subtypes. Special attention is paid to cellular interaction in the progression of melanoma, with emphasis on the subtypes.

Cell Movement↗
PubMedDate not supplied

Electron microscopic investigations of progressive early metastasis of cutaneous melanoma.

Primary metastasis of cutaneous malignant melanoma seems to occur especially via the initial lymphatics (IL). In samples of 50 melanomas examined by TEM melanoma cells (MCs), invading IL were demonstrated in 24 specimens. MCs were scarcely found in the immediate vicinity of blood vessels. After the MC has escaped from the MC-complex, connective tissue fibers and cells represent physiological guide-ways that lead the MC to the IL. Located close to the IL, the MC develops pseudopodium-like cytoplasmic processes that penetrate the abluminal fibrous network, fuse partially with the endothelium and destroy it. It seems to be important that the melanomas invade IL as single cells and not in form of cell clusters.

Humans↗