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Biomedical subjects

D Lambert

Publications and source records attributed to D Lambert.

At least 181 records · Page 10Linked to original sources
PubMed1985

Focal vascular headaches with focal arterial disease. An ultrasonographic analysis.

The relationship between migraine and premature stroke and heart disease has been firmly established in the literature. The probable mechanism relates to release of vasoactive agents locally that produce intimal changes and if chronic may lead to permanent changes to the artery. We have attempted to identify individuals at risk for premature stroke utilizing the highly accurate B-mode real time carotid ultrasonogram. Sixteen patients demonstrated varying degrees of focal dilatation or plaque disease and 44% had abnormal Doppler flow studies. Since many of these patients were asymptomatic during the examination it is suggested that vascular changes may be more persistent than were previously suspected. These plaques, in the setting of increased platelet aggregability may be responsible for the augmented risk of stroke. Precise identification of these individuals can be easily accomplished with B-mode real time scanning (High resolution), and will allow for safe followup if specific dietary or drug interventions are contemplated.

Adolescent↗
PubMed1985

Longitudinal analysis of categorical epidemiological data: a study of Three Mile Island.

The accident at the Three Mile Island nuclear power plant in 1979 led to an unprecedented set of events with potentially life threatening implications. This paper focusses on the analysis of a longitudinal study of the psychological well-being of the mothers of young children living within 10 miles of the plant. The initial analyses of the data utilize loglinear/logit model techniques from the contingency table literature, and involve the fitting of a sequence of logit models. The inadequancies of these analyses are noted, and a new class of mixture models for logistic response structures is introduced to overcome the noted shortcomings. The paper includes a brief outline of the methodology relevant for the fitting of these models using the method of maximum likelihood, and then the model is applied to the TMI data. The paper concludes with a discussion of some of the substantive implications of the mixture model analysis.

Accidents↗
PubMed1985

2,5-Diphenyloxazole as a probe for microsomal mono-oxygenation in human and rat liver.

2,5-Diphenyloxazole (PPO) is metabolized to one major fluorescent product by human liver and rat liver microsomes. PPO metabolism by human-liver microsomes involves more than one cytochrome P-450 isozyme, termed low-affinity and high-affinity components. At a substrate concentration of 0.1 microM, 95% of activity is due to the high-affinity component whereas at 100 microM 69% of activity is due to the low-affinity component. Inhibition studies with metyrapone and alpha-naphthoflavone at 0.1 microM and 100 microM suggest that the high-affinity component may reflect a 3-methylcholanthrene-inducible form of cytochrome. Therefore studies at low substrate concentrations may be a useful tool for cytochrome P-450 studies in man. Rat liver microsomes show linear kinetics indicating the involvement of one major form of cytochrome P-450.

Animals↗
PubMed1984

Vitamin E and lipoproteins in hyperlipoproteinemia.

The composition of vitamin E in serum and lipoproteins was determined in type I, IIa, IIb, IV and IV hyperlipoproteinemia and in normal subjects. Vitamin E was not specifically associated with any one of the lipoproteins but increased vitamin E levels were observed in VLDL when triacylglycerols level was increased (types IIb and IV); the same observations were noted in LDL when cholesterol level was increased (type IIa).

Cholesterol↗
PubMed1984

[Drug eruptions caused by lithium salts].

The systemic complications of therapy with lithium are well known, but toxidermia has only been recognised since 1968. The carbonate (Teralithe) is the lithium salt which is mainly responsible, leading to minor dermatoses: oedema, pruritus, alopecia, urticaria, purpura, allergic vasculitis, pretibial ulceration. Some more specific conditions have been individualised by their severity and rarity: acne form eruptions, seborrheic dermatitis, follicular keratoses and psoriasis-like dermatosis as well as true psoriasis induced or aggravated by lithium. The authors review the literature and discuss the pathogenesis of these toxidermias. The cause of some dermatoses can be explained, especially the allergic vasculitis and psoriasis lesions. The underlying mechanism of most of these conditions remains unknown, but excessive tissue concentrations of the drug probably play an important role in inducing these complications.

Acne Vulgaris↗
PubMed1984

[Hyperhidrosis].

Explore the source record for details and available documents.

Humans↗
PubMed1984

[Reference values of plasma and lipoprotein cholesterol and triacylglycerols in healthy children].

A sample of a reference population was selected from an all-inclusive population by a method based on strict physiological and clinical criteria. Sociological and ethnic factors as well as the biological plasma evaluation of the parents were used as family exclusion parameters. Cholesterol and triacylglycerols were measured in total plasma as well as in each lipoprotein fraction isolated by ultracentrifugation. The values are described as functions of sex and age. Total cholesterol varied little with age and sex. It is higher in girls except for HDL values. The maximum difference between boys and girls (age group 15-19 yrs) is mainly due to LDL-bound cholesterol. Plasma triacylglycerol values are generally higher in girls than in boys, particularly for VLDL. The minimum difference is in the age group 15-19 yrs.

Adolescent↗
PubMed1983

[Plasma glycerol and hepatic synthesis of lipoproteins in the Zucker fa/fa rat].

In order to determine if excess plasma glycerol originating in lipolysis increased the synthesis and secretion of lipoproteins in the liver of Zucker fa/fa rats, labelled (1-14C) glycerol was injected in vivo in the jugular vein, in the presence of (9,10-3H20 oleic acid and Triton WR 1339 to block plasma clearance of neoformed lipoproteins and to be secreted into the blood by the liver. Glycerol stimulated hepatic synthesis of lipids in the Zucker fa/fa rat. This resulted in an increased secretion by the liver of VLDL and lipoproteins comparable to chylomicrons.

Animals↗