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Biomedical subjects

D Kunze

Publications and source records attributed to D Kunze.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Endogenous lipid pattern, organ distribution and effect of diet on a fatty acid binding protein fraction of rat liver cytosol].

The endogenous lipid pattern of a fatty acid binding protein (FABP; synonym: "Z"-protein) in the cytosolic fraction of rat liver involves besides "free" fatty acids also phospholipids and mono-, di- and triacylglycerols. The relation between "free" fatty acids and the sum of all other lipids is nearly 1. In consequence of this result a correction of the idea is necessary that the FABP specifically binds only fatty acids. With immunological techniques it has been shown that the FABP has no organ-specificity and no immunological relation to the lipoproteins of the serum. A high content of fat in the diet (25% fat) compared with a low fat content of the diet (1% fat) led to an increase of the concentration of FABP in the cytosols of different rat organs (liver, intestinal mucosa, fat tissue and heart). Therefore a physiological function in the intracellular translocation of the fatty acids in different rat organs was inferred.

Animals↗
PubMed1981

Incorporation of 14C-linoleic acid in cerebrosides of psoriatic and normal human skin.

Psoriasis is marked by loss of glycoalyx. Glycocalyx is composed of glycoproteins and glycolipids such as cerebrosides. It was shown that the incorporation of 14C-linoleic acid in cerebrosides of normal and psoriatic human skin is different. In psoriatic epidermis and corium the turnover of this fatty acid is significantly elevated. It is suggested that in psoriasis the epidermal cell is not able to build up a regular carbohydrate sequences of lipids because the false carbohydrate chain activates the degradation of glycolipids and in compensating for the increased degradation raises the synthesis rate of glycolipids.

Carbon Radioisotopes↗
PubMed1981

[Epidemiology, clinical aspects, immunology and morphology of non-A, non-B hepatitis].

Examinations were carried out in a population group of 106 potentially contaminated females and in five donors, affected one year earlier within the frames of a restricted epidemic, caused by NANB-hepatitis virus. It was possible to differentiate a specific antibody-antigen system, identical to that of sirahi et al. The antigen was confirmed in 20 per cent of the females, 21 per cent of the contaminated did not get ill. The high SGPT level came in the foreground in the rest; 38 per cent had the signs of cholestasis. After one year, high transaminases were found in 43 per cent of the diseased, and biopsically--a chronic persistent hepatitis was found or a hepatitis with low activity. The chronification tendency correlates with the favourable clinical findings during the initial acute phase. The patients with prodromal phenomena, high transaminases and cholestasis showed a tendency to noncomplicated course and completely healing. The extraparenteral infection was confirmed, being conditioned by the close contact between mother and child or during breast feeding on one hand, on the base of the clinical manifestations, and biopsically--on the other.

Antibodies, Viral↗
PubMed1981

Phospholipid content and phospholipid fatty acid composition of red blood cells in enzyme defect hemolytic anemias.

The content and distribution of phospholipids (PL) in red blood cells (RBC) of PK and of G6PD deficiency were found to differ in both disorders. RBC immaturity could not be excluded as reason for PL alterations in PK deficiency. The relative diminution of phosphatidylethanolamine in G6PD deficiency may be connected with the enzyme depletion in this disorder and its influence on the PL of RBC membranes. Moist or all fatty acid deviations seem to be conditioned by RBC immaturity. Nearly all PL fatty acid aberrations in G6PD deficiency RBC were observed also in PK deficiency RBC. Additional deviations of PL fatty acids in PK deficiency RBC may be caused by the stronger immaturity of the cells in this disorder.

Anemia, Hemolytic↗
PubMed1980

Studies of selected enzymes of phospholipid metabolism in the dystrophic human muscle.

Proceeding from deviations of the phospholipid pattern in the muscle in progressive muscular dystrophy, the activities of a number of enzymes of phospholipid metabolism in the normal and dystrophic human muscle were measured. Twelve cases of the Duchenne type and four of the Becker-Kiener type were studied. The activities of CDP-choline:diglyceride-P-cholinetransferase, of CDP-choline:ceramide-P-cholinetransferase and of phosphatidylcholine degradation were determined in normal and dystrophic human muscle. A significant difference in enzyme activities between normal and dystrophic muscle could not be established. The activities of a phosphatidylethanolaminemethyltransferase and a transfer of P-choline directly from phosphatidylcholine to sphingomyelin could be excluded for normal human muscle. The significance of these results for the integration of phospholipid findings in ideas about pathogenesis of progressive muscular dystrophy is discussed.

Adolescent↗
PubMed1980

Basilar skull fractures in three horses.

Of three horses with basilar skull fractures, two died within 48 hours. The remaining horse was euthanatized because of a locomotion deficit. Clinical signs included epistaxis followed by ataxia. In each case, the basi-occipital bone and ventral portion of the calvarium were involved in the fracture. Diagnosis was based on clinical signs or radiographic appearance of guttural pouches, or both.

Animals↗
PubMed1980

Erythrocyte and plasma lipids in terminal renal insufficiency.

Lipids in erythrocytes and plasma of children and adults with terminal renal insufficiency were determined and compared with those of normal controls. The erythrocyte phospholipids in uremic patients were altered in phosphatidylethanolamine (absolutely and relatively elevated) and in lecithin (relatively diminished). Sphingomyelin, phosphatidylserine, total erythrocyte phospholipid content and cholesterol were within the normal range. The detailed analysis of the distribution of plasma phospholipids showed an increase in all phospholipids except phosphatidylserine. The unesterified plasma cholesterol was also found to be elevated. The fatty acid distribution in the individual erythrocyte phospholipids showed the following variations in comparison with controls: one main fatty acid was significantly decreased in sphingomyelin and in lecithin and slightly decreased in phosphatidylethanolamine. It could be shown that the lipid alterations in uremic erythrocytes were quite different from those in plasma. There were not typical signs for an increased lipid peroxidation in the erythrocytes of patients with renal insufficiency.

Acute Kidney Injury↗
PubMed1979

[New results on hyperglobulinemic purpura of Waldenström in childhood (author's transl)].

The case of a 13 year old girl with benign purpura hypergammaglobulinemica Waldenström. Besides the characteristic clinical symptoms and the respective laboratory results new findings we demonstrated, which might shed some light into the pathogenesis of this disease. The transformation rate of lymphocytes was decreased particularly after stimulation with ConA. The T-lymphocytes which are reduced in their function are unable to sufficiently control the activity of mesenchymal cells which results in an increased production of glycosaminoglycans. The demonstration of glycosaminoglycan-inclusion-bodies in the mononuclear bone marrow cells of the patient could be explained by the above mentioned mechanism. Upon therapy with D-penicillamine the clinical state improved along with a reduction of the sedimentation rate, the serum protein and the serum gamma-globulin.

Adolescent↗
PubMed1979

Myopathy induced by clofibrate treatment in normolipaemic patients.

On the basis of the occurrence of myopathy in a clofibric acid treated child with diabetes insipidus, three other children with the same diseases were examined in order to find indications for a myopathic side-effect of the drug. When the children were found to have increased creatine phosphokinase activity and EMG changes, two of the authors took clofibric acid themselves. In both test persons subclinical myopathy was produced. After stopping the drug, transitional hypertriglyceridaemia occurred. These side-effects should serve as a warning of an uncritical application of clofibric acid and its esters.

Child↗
PubMed1979

[Effect of procaine on the loss of erythrocyte phospholipids during blood preservation in ACD-AG-stabilizer].

The phospholipid changes of erythrocytes were investigated following the storage under blood bank conditions up to 42 days (ACD-AG-stabilisator) without and with addition of procaine (25 mM). The phospholipid loss of erythrocytes is described as two-step occurrence. The rapid decrease in the first three days is followed by a further loss up to the end of the storage period. The concomitant increase of phospholipid fractions of supernatant shows that the erythrocyte membranes lose their phospholipids mainly by a passive way. For the further loss of phospholipids the action of a phospholipase A is adopted. The addition of procaine hinders strongly the phospholipid loss of erythrocytes. The clinical importance of these procaine action is shortly discussed.

Acids↗
PubMed1978

Neonatal death dwarfism. (A further report).

Seven cases of rare "Neonatal Death Dwarfism" observed recently in three major Children's Hospitals in Australia are reported. These include Diastrophic Dwarfism, Achondrogenesis II, Lethal Form of Hypophosphatasia, Homozygous Achondroplasia, Minor Form of Asphyxiating Thoracic Dystrophy, Achondrogenesis II (?) and Unclassified Lethal Bone Dysplasia. In all the patients the clinical diagnosis was uncertain or incorrect, whereas a conclusive radiographic diagnosis could be made after X-ray examination in all but one of the cases. Skeletal survey should be performed in each case of neonatal death dwarfism.

Abnormalities, Multiple↗