Biomedical subjects
Publications and source records attributed to D K Sen.
A rare case of histopathologically proved case of congenital cystic eye in a one day old girl is described. It was an unusually large cystic mass bulging forwards stretching the upperlid. There was no rudimentary eyeball in the orbit. The cystic eye's predilection for the left eye has been pointed out for the first time in this article.
A rare case of unilateral cryptophthalmos have unique findings is reported. The lateral part of the left eye was replaced by downward extension of the frontal hairline. The left upper eyelid, except in the lateral 4mm fully developed portion, was replaced by a fold adherent to the underlying disorganized globe (6.9 mm). The lower lid, however, was fully developed. Ocular and systemic features of cryptophthalmos have been reviewed. Predilection for the left eye in unilateral cases has been hinted for the first time.
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Immunoglobulin levels in the ocular fluids have been estimated in normal subjects and lepromatous leprosy patients. In the normal tear, IgA is the major immunoglobulin while IgG is the only immunoglobulin detected in the aqueous humor. The immunoglobulin profiles in the tear and the aqueous humor in normal subjects are different. The mean IgA level in the tears of the lepromatous leprosy group is significantly lower than in the control patients. IgA and IgG levels are raised in the aqueous humor of some leprosy cases who had suffered from uveitis in the past and also in all cases with active endogenous uveitis. Therefore, in lepromatous leprosy the pattern of immunoglobulin alteration in the tear and the aqueous humor is not parallel.
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Out of 1086 cases of endogenous uveitis registered in the uveitis clinic of Irwin Hospital, New Delhi, India, over a period of 10 years from 1963-1972, 94 cases (8.6%) were within the pediatric age group 0-15 years. These cases have been analyzed in detail and the data on age, sex distribution, clinical types, course, complications, various etiological factors, and associated conditions have been tabulated. There were 29 cases within the age group 0-10 years. The youngest was six weeks old. Brief clinical data were: boys, 61.7%; bilateral cases, 45.8%, anterior uveitis, 40.4%; posterior uveitis, 47.9%; generalized uveitis, 11.7% and chronic cases 81.9%. Complicated cataract was the most frequent complication (25.5%) followed by band keratopathy (10.6%). The etiology could be determined in 52.1% of the cases. Tuberculosis was the commonest cause (31.9%) followed by toxoplasmosis (10.6%). There was one case of Behcet's disease where the ocular lesions preceded oral and genital lesions by two years. The series is conspicuous by the notable absence of sarcoidosis as a cause of uveitis. Comparative data on the incidence of childhood uveitis and its various etiological factors as reported by other workers have also been tabulated.