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Biomedical subjects

D K Novikov

Publications and source records attributed to D K Novikov.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Determining hypersensitivity to antigens by computing cells migrating from capillary tubes].

The test technique of inhibition of leukocyte and macrophage migration from the capillaries in the presence of a specific antigen is described. The method is highly sensitive and permitted to use a small amount of cells and many (up to 600 and more) capillaries. Sodium azide, phitohemagglutinin and incubation at 4 degrees C inhibited the cell migration from the capillaries. Dead cells did not pass from the capillaries into the medium. Tuberculin and BCG vaccine inhibited the migration of macrophages of guinea pigs immunized with BCG, but not with staphylococcus allergen.

Animals↗
PubMed1975

[Transfer to the leukocytes of neonates by means of the plasma of patients with tuberculosis and of healthy persons of the ability to depress migration under the influence of antigens of mycobacterium tuberculosis in vitro].

A study was made of the effect of the blood plasma of patients suffering from tuberculosis and of healthy individuals on the in vitro migration in the presence of old tuberculin and the BCG vaccine of the leukocytes of neonates sensitive and insensitive to these antigens. Plasma of tuberculosis patients and more rarely of healthy persons created favourable conditions for depression of migration with old tuberculin and the BCG vaccine of the neonatal leukocytes insensitive to it on autoplasma, i.e. realized the transfer of the cellulo-mediated reactivity. In some cases the neonatal leukocyte migration by tuberculin on autoplasma was absent on the plasma of patients with tuberculosis of the lungs. A conclusion was drawn that the blood plasma of neonates suffering from tuberculosis and of adult healthy individuals contained quantitatively and qualitatively different factors determining different sensitivity of their leukocytes to the Mycobacteria antigens.

Antigens, Bacterial↗
PubMedDate not supplied

[Blood serum cholesterol and the state of the immune system].

This review deals with information on the relationship of the immunity system and the lipid transport system. The data of literature and the results obtained by the authors indicated that an elevated level of cholesterol in the blood serum is associated with the increased activity of the immunity system. On the one hand, lipids and their metabolites produce an immunomodulating effect and, on the other hand, biologically active molecules, synthesized by immunocompetent cells in the process of their activation and proliferation, regulate lipid metabolism.

Animals↗