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Biomedical subjects

D K Goette

Publications and source records attributed to D K Goette.

At least 55 records · Page 3Linked to original sources
PubMed1982

Diffuse cutaneous reticulohistiocytosis.

A 65-year-old man had a diffuse, asymptomatic, cutaneous eruption of 5- to 15-mm reddish-brown, nonscaling papules in arcuate, annular, and serpiginous patterns for one year. The morphologic, light microscopic, and ultrastructural features of the skin lesions were typical of multicentric reticulohistiocytosis; however, the patient had no historic, clinical, laboratory, or roentgenographic evidence of arthritis. Spontaneous involution of the eruption occurred 17 months after onset. Several weeks later subacute myelogenous leukemia developed. The reported occurrence of isolated and multiple reticulohistiocytomas, diffuse cutaneous reticulohistiocytosis without systemic involvement, and multicentric reticulohistiocytosis with identical light microscopic and ultrastructural findings suggests that these conditions probably represent a spectrum of clinical expressions of similar etiologic and pathogenetic mechanisms.

Aged↗
PubMed1982

Treatment of keratoacanthoma with topical application of fluorouracil.

Keratoacanthomas (KAs) in 14 patients were treated with 20% fluorouracil ointment, two or three times daily, for two to four weeks. All lesions responded promptly and cleared in an average period of 3.4 weeks (range, one to seven weeks). Allergic contact dermatitis to fluorouracil occurred in two patients. This treatment response suggests that topical application of fluorouracil ointment is an effective alternative to conventional methods of treating KA.

Administration, Topical↗
PubMed1981

Unilateral palpable purpura. A manifestation of septic emboli from an infected aortofemoral bypass graft eroding the jejunum.

A 48-year-old man had a palpable purpuric eruption of the right lower extremity several years after a right aortofemoral bypass graft for obstructive atherosclerotic disease. Histologic examination revealed a leukocytoclastic angitis, and belated tissue Gram's stains disclosed clumps of Gram-negative organisms. The focus for the unilateral purpura proved to be an erosion of the jejunum by the bypass that yielded Enterobacter aerogenes on culture, as did one preoperative blood sample.

Aorta↗
PubMed1981

The mucocutaneous marker of pseudoxanthoma elasticum.

A patient with angioid streaks discovered ophthalmoscopically was evaluated in the dermatology clinic for pseudoxanthoma elasticum (PXE). Cutaneous markers for PXE did not appear in the usual locations; mucosal involvement of the lower lip was the only clinically ascertainable clue. The presence of the disease was confirmed by histologic examination of the oral mucosa. This case stresses the importance of familiarity with the mucocutaneous markers of PXE by members of the dental profession.

Humans↗
PubMed1981

Cutaneous lesions in brucellosis.

Two types of eruptions developed in a patient who had a fever of unknown origin: (1) tiny papules on the trunk and proximal extremities and (2) erythema nodosum-like deep dermal nodules on the legs. Brucella agglutinin test results were persistently negative, but B melitensis grew from the blood culture. Brucellosis should be considered in the differential diagnosis of a fever of unknown origin associated with a papular eruption with certain histologic features and/or erythema nodosum-like lesions. The histologic examination of cutaneous lesions may facilitate the diagnosis.

Adult↗
PubMed1980

Successful treatment of keratoacanthoma with intralesional fluorouracil.

Forty-one keratoacanthomas (KA) occurring in thirty patients were treated with weekly intralesional injections of 5-fluorouracil (5-FU). Forty lesions cleared after an average of three injections in an average of 3.4 weeks (range, 2 to 6 weeks). This response suggests that intralesional injections of 5-FU are the treatment of choice for KAs.

Adult↗
PubMed1980

Chondrodermatitis nodularis chronica helicis: a perforating necrobiotic granuloma.

Seventeen cases of clinically and histologically characteristic chondrodermatitis nodularis chronica helicis (CNCH) are presented. Thirteen histologic specimens revealed transepidermal elimination (TE) of necrobiotic material from the dermis. This elimination occurred through transepidermal channels, slits, or erosions overlying a dermal necrobiotic granuloma. The granuloma was surrounded by granulation tissue composed of histiocytes and lymphocytes. Telangiectasia and peripheral solar elastosis were common findings. The histologic features and clinical characteristics found predominantly in white men over 40 years of age suggest that CNCH etiologically and pathogenetically represents an actinically induced perforating necrobiotic granuloma.

Adolescent↗
PubMed1980

Chondrodermatitis nodularis chronica helicis. A transepithelial elimination disorder.

A patient with clinically and histologically characteristic chondrodermatitis nodularis chronica helicis (CNCH) had histologic evidence of transepithelial elimination (TE). Results of a review of 10 other histologic specimens of CNCH yielded three cases with features of TE. Pictorial presentation of yet another example was found in the literature. It is suggested that CNCH should be included in the ever-expanding group of TE disorders.

Epidermis↗
PubMed1980

Vaginal medications as a cause for varied widespread dermatitides.

Widespread dermatitis developed in three women after use of vaginal preparations. Besides allergic contact dermatitis, these cases involved erythema multiforme and a photosensitive eruption. Antigen absorption into the general circulation through the vaginal wall, and its deposition at distant skin sites, appeared to account for the spread of the eruption. This type of eruption is akin to the systemic, eczematous, contact-type dermatitis mediated by a systemically given drug in a primarily cutaneously sensitized person.

Aged↗
PubMed1980

Thyroid acropachy.

Thyroid acropachy (TA) developed in a 48-year-old man at least six years prior to clinically evident and symptomatic hyperthyroidism. The TA prompted a clinical workup for acromegaly on two occasions, with negative results. It usually develops after diagnosis or treatment of hyperthyroidism and usually occurs in conjunction with exophthalmos. In our patient, TA preceded the diagnosis and treatment of hyperthyroidism and was not associated with exophthalmos.

Humans↗
PubMed1980

Benign lichenoid keratosis.

Forty patients (39 white, one Oriental) had an isolated asymptomatic lichenoid keratotic lesion varying from bright red to violaceous to brown. The clinical diagnoses included basal cell carcinoma, actinic keratosis, Bowen's disease, and seborrheic keratosis. Histologically, lichenoid features prevailed, often indistinguishable from those of lichen planus. Although the majority of lesions occurred in sun-exposed skin and showed histologic evidence of solar elastosis, changes typical of carcinoma in situ were absent. The correct pathologic diagnosis of benign lichenoid keratosis was initially made in only seven cases.

Adult↗