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Biomedical subjects

D K Goette

Publications and source records attributed to D K Goette.

At least 19 recordsLinked to original sources

Chilblains (perniosis).

Unfamiliarity of physicians with chilblains (perniosis) gives rise to unnecessary hospital admissions with expensive laboratory and radiologic evaluations and, at times, hazardous therapy. Seven cases of chilblains were seen in San Francisco from November 1986 through January 1987. The patients presented with pruritic, at times painful, purple acral patches or plaques on the fingers, toes, and nose after exposure to a cool or a cold, damp environment. Histologic examination in two cases revealed a perivascular lymphocytic infiltrate with endothelial swelling of the subcutaneous fat and of the upper and lower dermal plexus.

Adult

Transepithelial elimination of benign and malignant tumors.

Transepithelial elimination is a common physiologic mechanism by which the skin rids itself of externally introduced or endogenously generated waste and foreign material. Although originally observed mostly as a process of elimination of altered connective tissue, transepithelial elimination has recently been described in deep mycoses, bacterial diseases, and nonspecific and foreign-body granulomas. This report describes transepithelial elimination of benign and malignant tumors.

Adult

Eccrine proliferation with follicular mucinosis.

Proliferation of the eccrine sweat duct epithelium has been associated with skin tumors, especially keratoacanthomas and basal cell carcinomas. We report our observations on the extensive sweat gland changes in a patient who had idiopathic follicular mucinosis.

Adult

Transepithelial elimination of granulomas in cutaneous tuberculosis and sarcoidosis.

Transepithelial elimination of granulomas was observed in histologic specimens taken from involved skin of a patient with disseminated tuberculosis and two patients with sarcoidosis. This phenomenon, previously also observed in other granulomatous disorders, represents one of the skin's several mechanisms to rid itself of endogenous or exogenous waste material.

Adolescent

The significance of transepithelial elimination in dermatologic surgery.

Transepithelial elimination (TE) was found to be an important physiologic mechanism of riding the skin of foreign material introduced during cutaneous surgery, as evidenced in the histologic examination of reexcision specimens. Thus, TE of suture material, Monsel's granulomas, and starch granules are pictorially documented in several brief case reports.

Adult

Calcifying neurothekeoma.

A 10-mm, asymptomatic, slowly growing, dermal nodule was present on the ankle of a 62-year-old man for 6 months. Histologically, the nodule was shown to be a neurothekeoma, a recently described benign cutaneous tumor of nerve sheath origin distinct from neurofibroma or neurilemmoma. This case merits attention because extensive dystrophic tumoral calcification in the lobules prompted an initial misdiagnosis of foreign body granuloma. Calcification in neurothekeoma has not previously been described.

Ankle

Collagènome perforant verruciforme.

Transepidermal elimination of foreign material or altered tissue from the dermis has been reported in the literature with increasing frequency. We recently observed a rather dramatic example of transepidermal elimination of altered collagen that seemed to fit the original description of collagènome perforant verruciforme. Although described in Europe, to our knowledge, this entity has not been reported in the American literature.

Aged

Postirradiation angiosarcoma.

A 61-year-old woman developed a cutaneous angiosarcoma of the lower abdomen in the site where she had received radiotherapy for squamous cell carcinoma of the cervix uteri 23 years earlier. The rarity of this event and the dermatologist's general unfamiliarity with this late complication of radiation therapy have prompted a review of cutaneous postirradiation angiosarcoma.

Abdomen

Postirradiation malignant fibrous histiocytoma.

A slowly growing, firm, asymptomatic tumor developed in the skin overlying the left scapula of a 72-year-old woman during a six-month period. Twenty-seven years earlier, she had radiation treatment to that site for an intraductal carcinoma of the left breast. The histopathologic diagnosis was malignant fibrous histiocytoma (MFH). The rarity of this late complication of radiation therapy is reflected by a few reports in the medical literature of cutaneous MFH as late radiation sequelae.

Aged