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Biomedical subjects

D Jovanovic

Publications and source records attributed to D Jovanovic.

At least 55 records · Page 3Linked to original sources
PubMed1979

Genotypic characterization and clinical evaluation of an influenza A/Texas/1/77 (H3N2)-like recombinant: RIT 4199.

The RIT 4199 (H3N2) strain was obtained by recombination of PR/8/34 (H0N1) and A/Alaska/5/77 (H3N2) isolates. Its genetic composition was determined by RNA-RNA hybridization and by identification by gel electrophoresis of the double-standard RNA formed. The RIT 4199 was inoculated intranasally to 27 seronegative volunteers at a dose of 10(7.3)EID50. The results show that it is suitable for live vaccine strain.

Adult↗
PubMed1979

Protective efficacy of live influenza vaccines. Its assessment in field and experimental conditions.

Cost benefit estimates of immunization programs are critically dependent on an accurate and reliable assessment of the protection offered by the vaccines. Consequently, the selection of appropriate parameters of protection becomes an issue of major importance. The protective efficacy of live influenza virus vaccines has been established for several vaccinal strains used in routine immunization. This was established under conditions of natural and artificial exposure to both homologous and heterologous influenza viruses. Reduction in the incidence of specific disease--respiratory illness, confirmed by influenza virus isolation and/or four-fold increase in serum HAI titer, was found to be significant. These data will be discussed in relation to available epidemiological models that have been developed for the evaluation of disease modifying properties of immunoprophylactic agents.

Adult↗
PubMed1978

Correlation between rate of infection and preexisting titer of serum antibody as determined by single radial hemolysis during and epidemic of influenza A/Victoria/3/75.

During an outbreak of infection with wild-type influenza A/Victoria/3/75 virus, a correlation was established between the rate of infection and the preepidemic titer of serum antibody to that virus as measured by the single radial hemolysis technique. Titers of antibody determined by the hemagglutination inhibition method as well as by the single radial hemolysis technique were directly correlated with the rate of infection. By use of the single radial hemolysis technique, the 50% protective titer of antibody was calculated for a population of recipients of live influenza A/Victoria/3/75 virus vaccine.

Antibodies, Viral↗
PubMed1978

Determination of meningococcal antibodies by microassay.

A modified microassay procedure, using triphenyltetrazolium chloride as a germination indicator, was compared with a macroassay method proposed by the World Health Organization for determining the level of antibodies before and after immunization with Group A meningococcal polysaccharide vaccine. There was excellent agreement between the results obtained by the two methods. The vaccine used appeared to be safe and immunogenic.

Adult↗