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Biomedical subjects

D J Hall

Publications and source records attributed to D J Hall.

At least 109 records · Page 6Linked to original sources
PubMed1984

Early synthesis of specific cytoplasm proteins is correlated with the rate of exit of lymphocytes from the resting state.

We investigated the initiation of synthesis of proteins in human lymphocytes exposed to the mitogen phytohemagglutinin (PHA) for 6 h. Radiolabeled proteins in three subcellular fractions, cytoplasmic, nuclear salt wash, and nuclear, were separated on polyacrylamide gels. Compared with cells incubated for the same time in the absence of PHA only two cytoplasmic proteins of Mr 51 and 60 kd showed increased synthesis in a dose-dependent fashion. Synthesis of the 60-kd protein shows the strongest correlation with rate of entry into the first S phase and with rate of cellular aggregation. Thus, the 60-kd protein appears to be a major early response-associated protein for entry of lymphocytes into the first S phase after PHA stimulation.

Blood Proteins↗
PubMed1984

Coxa plana--the fate of the physis.

Eighty patients who had unilateral coxa plana and who had been treated conservatively were followed to a mean age of sixteen and one-quarter years, and their cases were reviewed for radiographic evidence of a disturbance of the femoral capital growth plate. This physeal involvement was inferred by the presence of one or more of five findings: premature physeal closure, overgrowth of the greater trochanter, change in physeal shape, lateral protrusion of the capital nucleus, and medial bowing of the femoral neck. Premature physeal closure, which was more common in the girls than in the boys, occurred in 25 per cent of the affected femoral heads, and 90 per cent of the patients showed some interference with normal physeal growth in the affected femoral head. A direct correlation was found between the severity of the physeal involvement and the ultimate deformity of the femoral head. The possible causes of interference with physeal growth and damage are discussed.

Bone Diseases, Developmental↗
PubMed1984

Lesions of the vulva.

Lesions of the vulva are common and are often associated with unnecessary and sometimes harmful delays in diagnosis and definitive therapy. Simple office biopsies, performed prior to treatment, permit histologic classification of the lesion and provide a basis for therapeutic recommendations.

Adult↗
PubMed1983

Bleomycin-mitomycin C in advanced squamous cell carcinoma of the female genital tract.

Bleomycin and mitomycin C have been reported to be active against advanced squamous cell carcinoma of the uterine cervix. Miyamoto et al reported a total response rate of 93% and complete response in 80% of the first 15 patients treated by sequential combination of bleomycin and mitomycin C. Updated results by Miyamoto reveal an 88.3% total response rate with a 65.3% complete response. However, others have reported poor results using the protocol outlined by Miyamoto. Using this protocol, 11 patients with advanced squamous cell carcinoma were treated at the authors' institution. There were no complete responses: one patient with partial response (9%), four with stable disease (36%), and six (55%) with progressive disease.

Adult↗
PubMed1982

Commitment and proliferation kinetics of human lymphocytes stimulated in vitro: effects of colchicine on mitogen response.

We have examined the effects of colchicine on concanavalin A (Con A)-and phytohemagglutinin (PHA)-stimulated human peripheral blood lymphocytes and from the time course of proliferation have extracted the relative size of the responding cell population, the rate of entry of this population into S-phase, and the length of the lag period. Additions of colchicine at any time did not appear to influence the size of the responding population nor did it greatly affect the duration of the lag period. Only the rate at which the cell population enters initial S-phase is a function of the time of previous exposure to colchicine. Colchicine does not appear to inhibit the commitment of stimulated lymphocytes to enter the cell cycle. Rather, it merely serves to decrease the biochemical processes responsible for fixing a maximal rate of entry into S-phase.

Cell Division↗
PubMed1982

Surgical-orthodontic treatment planning for simultaneous mobilization of the maxilla and mandible in the correction of dentofacial deformities.

Simultaneous mobilization of the maxilla and mandible is indicated for the optimal correction of specific dentofacial deformities, as discussed in the preceding publication. Because of the added complexity of this type of surgical-orthodontic treatment, it is important to determine the absolute need for surgery and to construct a detailed blueprint of the specific changes to take place at the time of surgical intervention as well as those to be made by the orthodontist prior to initiation of any treatment. The intent of this article is to describe a technique of treatment planning which includes cephalometric prediction tracings, model surgery, determination of orthodontic-surgical sequencing, splint construction, and specific sequencing of surgery. When followed, these guidelines will enable the surgeon and the orthodontist to accurately determine the need for simultaneous mobilization of both the maxilla and the mandible and provide more predictable and stable results when it is performed.

Cephalometry↗
PubMed1982

The place of general practitioner hospitals in the organization of hospital services.

After many years in which general practitioner hospitals have had little encouragement towards constructive planning they now find themselves being viewed in a more favourable light. Health Authorities should attempt to assess the potential of such hospitals and make plans for their future. It will be necessary for the isolation of the hospitals from the mainstream of district planning to be yielded up in return for an assurance of a fully effective future role.

England↗
PubMed1982

A study of six general practitioner hospitals in Tunbridge Wells Health District.

At the reorganization of the NHS in 1974 Tunbridge Wells Health District inherited an unusual distribution of beds: more than 25% of beds in general medicine, geriatrics and surgical specialties were in general practitioner hospitals. This article describes a study that attempted to obtain information about the work being done in the GP hospitals, assess their potential and plan their future. The ways in which the DMT is following up the study are outlined. A subsidiary study on transfer from general hospital to GP hospitals is also described.

Catchment Area, Health↗
PubMed1982

Training needs.

Explore the source record for details and available documents.

Medical Record Administrators↗
PubMed1982

The adnexal mass.

Accurate diagnosis of the adnexal mass requires knowledge of embryology, anatomy, and physiology. Bimanual pelvic examination remains the primary and most practical means of detecting and evaluating adnexal pathology. Selective use of diagnostic techniques will help determine the nature and extent of involvement. Prompt and specific diagnoses facilitate therapy and improve results.

Adnexal Diseases↗
PubMed1981

cis-Platinum in gynecologic cancer. III. Toxicity.

The toxicity of cis-dichlorodiammineplatinum was evaluated in 41 patients who were treated for squamous cell carcinoma of the cervix or epithelial carcinoma of the ovary, with a dosage schedule of 60 mg/m2 every 3 weeks. Ototoxicity occurred in 33.3% of the patients serially tested, and anemia occurred in 48.8%. Leukopenia occurred in 29.9% and thrombocytopenia in 2.2% of courses administered. Nephrotoxicity was seen in 61% of patients as determined by evaluation of blood urea nitrogen and in 70.7% by serum creatinine elevation. Urine dipstick protein and 24 hour urinary protein determinations were evaluated. Suggestions are made in regard to the use of these determinations as a guide to modification of dose and duration of therapy.

Adult↗
PubMed1981

Commitment and proliferation kinetics of human lymphocytes stimulated in vitro: effects of alpha-MM addition and suboptimal dose on concanavalin A response.

We have examined the effect of alpha-methylmannoside (alpha-MM) addition to concanavalin A (con A)-stimulated peripheral human lymphocytes. With a previously established kinetic model, we have, from the time course of proliferation, extracted the responding clone size, rate of entry of this clone into S phase and the length of the lag period. We have studied the effect of con A dose and time of addition of alpha-MM to optimally stimulated cells on these kinetic parameters. We show that neither a low dose of con A nor an early addition of alpha-MM to optimally stimulated cells results in a change in the responding clone size. This is, all of the potentially cells appears to become "committed" to enter the cell cycle regardless of the presence of alpha-MM early in the culture or in the presence of suboptimal stimulation. However, the rate at which these committed cells enter the first S phase is a function of the dose of con A and time of addition of alpha-MM and varies over a wide range. It is the variation in this parameter that accounts for virtually all of the diminished response previously interpreted as a time-dependent irreversible commitment of mitogen-stimulated cells. The previous work using only fixed time points for measuring thymidine uptake and the concept of commitment must be reevaluated in light of the kinetic evidence presented.

Adult↗