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Biomedical subjects

D Holmes

Publications and source records attributed to D Holmes.

150 records · Page 9Linked to original sources
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Suspected inappropriate secretion of antidiuretic hormone in a male with mental retardation.

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder in which a sustained release of antidiuretic hormone occurs because of certain diseases, pharmacological agents, or trauma. Fluid volume expands with a resultant hyponatremia which, depending on the degree, may be asymptomatic or result in death. This case report describes a 38-year-old male in whom SIADH was strongly suspected secondary to Tegretol therapy to control a seizure disorder. Medical consultation is imperative for these patients before administering a fluid challenge during general anesthesia.

Adult↗
PubMedDate not supplied

Social networks and mortality in an inner-city elderly population.

The authors address some of the methodological problems found in earlier investigations of the relationship between social networks and mortality. Of particular concern was the use of rudimentary measures of social interaction in previous work. Utilizing nineteen social network variables, the authors examined 155 elderly residents of midtown Manhattan single-room occupancy hotels. On three-year follow-up, twenty-eight persons had died. Discriminant function analysis indicated that ten of nineteen network variables were relatively strong discriminators between survivors and non-survivors (i.e., standardized coefficient of .20 or greater). The network variables cut across all categories of social interaction, thereby revealing why, despite the few network variables used in previous studies, nearly all had been significant.

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