Functional behaviour of transferrin.
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Biomedical subjects
Publications and source records attributed to D Hahn.
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PURPOSE: Color Doppler sonography has gained considerable recognition as a noninvasive method to detect carotid artery disease and to assess the degree of carotid artery stenosis. However, results are highly operator-dependent and cannot be presented as survey images. The purpose of this study was to evaluate real-time 3-dimensional (3D) power Doppler sonography as a method for screening for atherosclerosis in the carotid arteries. METHODS: We prospectively screened 75 patients for carotid artery disease using both conventional color Doppler sonography and 3D power Doppler sonography, and the results from the 2 modalities were compared. A total of 150 common carotid arteries, 150 internal carotid arteries, and 150 external carotid arteries were examined utilizing a 7.5-MHz linear-array transducer combined with tissue harmonic imaging. RESULTS: Color Doppler sonography detected 297 normal or atherosclerotic arteries without stenosis, 57 arteries with mild (1-49%) stenosis, 41 with moderate (50-69%) stenosis, 32 with severe (70-99%) stenosis, and 9 with occlusions. The degree of stenosis determined by color Doppler sonography correlated with that determined by 3D power Doppler sonography (r = 0.982-0.998). Moreover, there was a good correlation between the measurements for both the length of the lesion and its distance from the bulb as determined by the 3D volume surveys and by color Doppler sonography (r = 0.986). The interobserver variability rate was 3.7% +/- 0.5%. Generally, the acquisition and reconstruction of the 3D data took less than 5 minutes. CONCLUSIONS: 3D power Doppler sonography is easy to perform and is an accurate method in screening for atherosclerotic lesions of the carotid arteries. Moreover, it provides excellent 3D volume surveys that may be helpful in the planning of surgical treatment.
Eighty in vitro experiments were performed with single (n = 51) or multiple (n = 29) gallstones in order to find out which parameters are of prime importance for their disintegration by extracorporeal shock waves. A Dornier lithotripter and an upper limit of 1,500 discharges were employed. Although computed tomography density was significantly lower in cholesterol stones than in the noncholesterol stones (p less than 0.0001) and although the latter were significantly more often radiopaque (p less than 0.0001), we found no clear-cut correlation between the cholesterol content or computed tomography density and the degree of fragmentation of the stones. The most important variable which limited successful disintegration was the total stone volume. In stones with a mean total volume of 0.83 ml +/- 0.25 S.E. (diameter for single stones = 11.5 +/- 0.9 mm), none of the fragments exceeded 2 mm, whereas in stones with a mean volume of 3.6 ml +/- 0.64 (diameter = 17.2 +/- 1.5 mm) at least one fragment larger than 2 mm remained (p less than 0.002). Under the in vitro conditions, fragmentation was similar in multiple and solitary stones, provided the volume of the stones was comparable. These data show that, in general, the number and size of the stones, i.e. their total volume, and much less significantly their chemical composition are the major determinants of fragmentation by extracorporeal shock waves.
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Angiomyoma is a benign tumor that arises from soft muscular tissue within the blood vessel wall. This lesion has been found in different organs. The preferential location of these tumors is the lower extremity. We describe the rare case of a hepatic angiomyoma and present the radiologic findings of computed tomography and magnetic resonance imaging.
Glomus organs are small arteriovenous anastomoses that are chiefly responsible for thermoregulation of the distal portion of the extremities. Glomangiomas are benign tumors of these bodies. Glomangiomas occur preferentially in the fingers and toes, but some case reports have described primary glomangiomas in the respiratory or gastrointestinal tract and the genitals. To date, no glomangiomas of the liver have been observed. We report on a 61-year-old patient in whom routine ultrasound disclosed a subcapsular well-defined mass in the liver. On imaging studies, no correspondence to the usual liver tumors was found. Magnetic resonance-guided biopsy showed a primary glomangioma of the liver. Clinically, the patient had no appetite and lost weight over several months. Due to the patient's weight loss and potential malignant transformation, the tumor was excised. Histologic work-up confirmed the diagnosis of a glomangioma with no signs of malignancy.
PURPOSE: Vena cava filter (VCF) application is the method of choice to prevent recurrent pulmonary embolism in patients with deep venous thrombosis. Because of the reported complications after VCF placement we summarize our long-term follow-up results with the LGM and Titanium Greenfield (TG) devices. METHODS: Eighty-seven LGM VCF and 17 TG VCF were placed in 104 patients (average age 64 years). The follow-up examinations were performed by color-coded duplex sonography, plain radiographs, cavography, and computed tomography (CT). The maximum observation time was 81 months. RESULTS: Filter migration occurred in 11% (8/76) of the LGM VCF and 15% (2/13) of the TG VCF. Vena cava thrombosis was seen in 17% (13/76) of the patients with an LGM VCF and in 31% (4/13) of those with a TG VCF. The patency rate was 95% (72/76) for the LGM VCF and 92% (12/13) for the TG VCF. Pulmonary embolism was noted in 3 patients after LGM VCF insertion and in no patient after TG VCF insertion. CONCLUSION: A VCF should only be inserted in a patient after pulmonary embolism and when there is strict proof of the indication.
PURPOSE: The treatment of inoperable tracheobronchial stenoses with Palmaz stents is analyzed in terms of the clinical effect, typical complications, and long-term follow-up. METHODS: Twenty-seven Palmaz stents were placed in 22 patients with the help of a rigid bronchoscope. RESULTS: Stents were implanted in the distal trachea, the main bronchi, and the lower lobe bronchi. Twenty-one of 22 patients reported an immediate subjective improvement in their respiratory situation. The mean survival time was 12 months; in two patients the stents were well tolerated for up to 40 months. A redilation of three stents was successful up to 33 months. In three cases a dislocation of the stent was observed; after bronchoscopic retraction a new stent was successfully implanted in each case. CONCLUSIONoff Treatment of inoperable tracheobronchial stenoses with the Palmaz stent is a safe procedure that provides an immediate improvement of the patient's pulmonary situation. The Palmaz stent shows a minimal complication rate in the long-term follow-up.
The goal of this work was to verify in a phantom study the necessity of a calibration method for comparison in dynamic contrast-enhanced magnetic resonance imaging (MRI) examinations. A perspex phantom with a dilution series of Gd-DTPA was used to measure the dynamic signal enhancement of a sequence. With nine MRI scanners from Bruker (0.23, 0.5, and 2 Tesla), Philips [0.5 and 1.5 Tesla (ACS-NT and S15)], and Siemens (0.2, 1.0, and 1.5 Tesla) one 2D FLASH and two 3D FLASH experiments were performed under identical measurement conditions. Under different measurement conditions (2D and 3D FLASH, TR, TE, FA) different characteristics in signal enhancement exist on a scanner. The same measurement conditions at different scanners (same magnetic field strength) also result in different signal enhancement. Dynamic contrast enhanced MRI examinations from different measurement conditions or scanners cannot be compared. To solve this problem a calibration is needed.
In a preliminary study 20 patients underwent breast examinations by magnetic resonance (MR) imaging without and with Gd-DTPA as contrast medium. All carcinomas enhanced, whereas dysplastic tissue enhanced slightly or not at all. Significant additional diagnostic information was available on the Gd-DTPA examinations in at least four of 20 cases compared with MR without contrast medium and X-ray mammography. Our preliminary results indicate that MR imaging of breast using Gd-DTPA may be helpful for the evaluation of dense breasts and the differentiation of dysplasia and scar tissue from carcinoma.
Fifty-seven biopsy proven breast masses have been examined at our institution by magnetic resonance (MR), mammography, and ultrasound. The three techniques have been evaluated concerning their capability to visualize the lesion and the diagnostic information obtained. Magnetic resonance proved comparable to mammography and superior to sonography in the fatty to medium dysplastic breasts but inferior to the combined examination by mammography and sonography in the dense breasts. In some selected cases, however, special advantages of MR have been found.
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Sialography is at present performed either by the subtraction mode or conventional technique only. We utilised a high-resolution digital radiography system with a 1024 x 1024 matrix in 17 patients with diseases of the salivary glands. Digital subtraction ductography in lateral projection was followed by digital radiography in adequate projections. In that way advantages of both methods could be combined in one. Additional advantages are possibilities of storage and communication of the digital data.
Muscular imaging (sonography, computed tomography, magnetic resonance imaging) has proved to be worthwhile for myologic diagnostic purposes during the past few years. In 319 patients suffering from generalized neuromuscular diseases, muscle atrophies or hypertrophies and the degree and distribution of mesenchymal alterations in skeletal muscles were documented. The various imaging techniques were of assistance defining the optimal biopsy site, and the preparation of electro-myographic examinations. Real time sonography proved to be the method of choice for screening purposes and for documentation of fasciculations. Because of higher sensitivity and superior depiction of soft tissue pathology, magnetic resonance imaging supported the further diagnostic work-up in certain cases. Because of irradiating side effects, computed tomography was applied just for evaluation of muscle involvement in advanced stages of neuromuscular diseases in adults.
A 61-year-old man with septic enophthalmitis and cramps in the upper abdominal region, fever and leukocytosis was admitted to hospital. Ultrasound examination revealed an inhomogenous enlargement of the left kidney with normal conturation and swollen, in part almost transonic, renal parenchyma. In the area of the left kidney CT demonstrated an enlarged tumor with inhomogenous and destroyed structures. The left kidney was removed. Histology confirmed the diagnosis of renal parenchymal malakoplakia.