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Biomedical subjects

D Hahn

Publications and source records attributed to D Hahn.

At least 253 records · Page 14Linked to original sources
PubMed1983

Pancreatic grafts. Nuclear perfusion imaging to detect vascular complications and rejection crises.

Perfusion studies with 99m-Tc-DTPA were used routinely to investigate renal grafts. Efforts were made to employ this technique in monitoring the perfusion of pancreatic grafts. A total perfusion failure is as reliably detectable as in renal grafts. Smaller perfusion alterations could be demonstrated by follow up studies. It appears to be feasible to differentiate the salivary edema, well known from animal experiments, from a rejection reaction with the help of other parameters (e.g. creatinine). Further clinical studies, however, are necessary to confirm these results.

Adult↗
PubMed1983

[2-dimensional echoencephalography or cranial CT in premature or newborn infants with suspected intracranial hemorrhages].

65 newborns or low-birthweight infants with suspicion of intracranial hemorrhage were examined with B-mode small part scanners. In 12 cases the diagnosis made by ultrasound could be compared with CT. There was a similar accuracy of both methods in case of intraventricular (IVH) and subependymal (SEH) hemorrhage. SEH seems to be easier detected by US. On the other hand there are problems in diagnosing subdural (SDH) and intracerebral (IHC) hemorrhages by US. These problems are caused by the adjacent skull, but does not exist for CT. B-mode-Echoencephalography is the method of choice for examination of high risk infants and for the follow up, because US is a cribside method and of high diagnostic accuracy. CT-studies should be done in case of hemorrhage adjacent to the skull and if the US-diagnosis seems not to be reliable.

Cerebral Hemorrhage↗
PubMed1983

[A pulsating tumor in the chest wall].

A pericardial constriction with calcification and a pulsating cyst is an unusual outcome after a pericardial windowing. The application of cardiac computed tomography evaluating the morphological parameters of the heart chambers and the adjacent vessels is an appropriate noninvasive method in the diagnostics of pericardial constriction.

Abscess↗
PubMed1983

[Value of posttherapeutic scintigraphy for the demonstration of distant metastases of differentiated carcinomas of the thyroid gland].

The value of posttherapeutic scintigraphy performed at discharge with the remaining radioactivity after an ablative radio-iodine therapy was studied in 190 patients with differentiated carcinomas of the thyroid gland (54% papillary and 46% follicular carcinomas). 163 patients (86%) had no signs of disease. 33 patients had distant metastases. In six out of them, the examination method allowed a first demonstration of metastases. In seven further cases, additional, hitherto unknown foci were found. There was a specificity of 100% and a sensitivity of 82% (no false positive findings, six false negative findings). Further to the usual image-producing examination methods (native X-ray diagnosis, sonography and CT), posttherapeutic scintigraphy furnishes early information about the formation of distant metastases. Therefore it is helpful to indicate a regional percutaneous X-ray therapy and to assess the prognosis.

Adenocarcinoma↗
PubMed1982

[Results of functional scintigraphy using 131J-hippurate in preoperative diagnosis of patients with kidney tumors: influence on surgical treatment and predictive value for retentional serum levels].

156 patients with renal tumors were studied using 131J-hippurate to assess the validity of functional scintigraphy in preoperative diagnosis and to compare it with the serum levels of Creatinine and Urea before and after tumor nephrectomy. If the contralateral, non tumor bearing kidney had a clearance (RNCL) of more than 200 ml/min, no pathological elevation was found postoperatively. If the RNCL was between 150 and 200 ml/min, the postoperatively elevated serum levels of Creatinine and Urea normalized within 3 weeks after surgery. Elevation persisted for longer than 3 weeks if the RNCL was between 100 and 150 ml/min. In RNCL below 120 ml/min an elevation was found even 6 months after surgery. Only if the RNCL was less than 100 ml/min (2% of all cases), instead of tumornephrectomy, an organ-conserving surgery was performed. In these cases, the results of renal scintigraphy yielded additional information in deciding the type of non-radical surgery. Therefore, renal functional scintigraphy does not need to be performed in patients with renal tumors under the following conditions: 1. no elevation of Creatinine and Urea preoperatively and 2. normal morphological findings (sonography, IVP, angiography, CT) of the contralateral kidney.

Creatinine↗
PubMed1981

[Pancreas grafts. Nuclear medical perfusion to exclude vascular complications and rejection crises (author's transl)].

Perfusion studies with 99m Tc-DTPA, which has hitherto been used routinely to investigate renal grafts, have also proved useful for monitoring the perfusion of pancreas grafts. A total perfusion failure is equally reliably demonstrable as in renal grafts. Quantitatively smaller perfusion alterations can be demonstrated by monitoring the course. It seems possible to differentiate the salivary edema of a rejection reaction, well known from animal experiments, with the help of other parameters (e. g. creatinine). Further clinical studies are however necessary to confirm these results.

Adult↗
PubMed1981

[Significance of ultrasonography in diagnosing complications following renal transplantations (author's transl)].

Routine follow-up examinations by ultrasonography after renal transplantation were performed in 72 patients from December 1978 until March 1980. The aim of these controls was to recognize local complications in the area or surgery in order to differentiate from a rejection reaction in patients with unclear clinical symptoms. 22 out of 72 patients had local complications. 15 out of those 22 were detected by ultrasound in a state without clinical symptoms, which then could be treated by surgical or urological intervention. We therefore believe that routine follow-up examinations after renal transplantation by ultrasound are indicated in order to recognize local complications. Nuclear procedures should be employed if alteration of blood flow or disturbed function of the transplanted kidney are considered.

Graft Rejection↗
PubMed1980

Cis-Dichlorodiammine platinum and adriamycin therapy for advanced gynecological and genitourinary neoplasms.

Cis-Dichlorodiammine platinum (DDP) 75 mg/m2 on days 1 and 8 and Adriamycin (ADR) 60 mg/m2 on day 1 were used in 31 patients with advanced gynecological and genitourinary neoplasms. The DDP was given by 6 hours intravenous infusion with 2 liters of 5% Dextrose and 0.5 normal saline using Mannitol and/or furosemide diuresis. Courses were repeated every 21 to 28 days. Responses were seen in 7 of 8 patients with germinal cell neoplasms (5 complete, 2 partial) with a median duration of eight months. A partial response was obtained in 3 of 7 patients with bladder carcinoma with a median duration of three months. There were four partial responses obtained in 9 patients with ovarian carcinoma with a median duration of five months. Toxicities included nausea and vomiting in all 31 patients, nephrotoxicity (serum creatinine > 2 g/100 ml) in patients, tinnitus and/or high frequency hearing loss in 10 patients, and neurotoxicity (peripheral neuropathy, normal pressure hydrocephalus, papilledema) in 8 patients. Severe leukopenia (WBC < 2000/cu mm) and thrombocytopenia (< 100,000/cu mm) occurred in 25% and 45% of evaluable courses, respectively and necessitated dosage reduction in all and delay of therapy in some patients. Peak plasma Pt levels were 2.61 +/- .18 microgram/cc on day 1 and 3.52 +/- .39 microgram/cc on day 8 with a longer terminal half-life on day 8 (252 hours) compared to day 1 (156 hours). Peak plasma ADR levels ranged from .53 to 1.67 N moles/cc with an average terminal half-life of 22.8 hours. This agrees with values of ADR when given alone. This dose and schedule of DDP-ADR is active against advanced gynecological and genitourinary neoplasms, but the amount of toxicity seen indicates that modifications will have to be made.

Adolescent↗
PubMed1980

Critical examination for the presence of a low molecular weight fraction in serum iron.

Native human pool serum and individual sera were ultrafiltered by Pellicon ultrafilters (Millipore) and the ultrafiltrates were extracted by an ammonium pyrrolidinedithiocarbamate/methylisobutylketone system after addition of different internal iron standards to three of four identical ultrafiltrates. The extracts were examined for iron content by atomic absorption spectrometry. During ultrafiltration pH 7.4 was maintained by a constant atmosphere of a CO2/air mixture. Low molecular weight iron in native human sera from normal, normal orally iron substituted and siderotic individuals was found to be less than 0.05 micrograms/100 ml. Elevating serum citrate to 3-fold normal had no effect on this result. More iron became ultrafiltrable if the serum pH were lowered by citric acid as compared with hydrochloric acid.

Citrates↗
PubMed1978

[Parameters of collagen biosynthesis in cotton pellet granuloma of rats on iron deficiency (author's transl)].

Rats of Wistar strain, of same age, were kept on iron free diet up to nearly absolute iron deficiency in iron depots. Afterwards granuloma was produced by implantation of cotton pellets subcutaneously. For characterization of the collagen biosynthesis in the granuloma the neutral salt soluble collagen and the activity of the prolyl hydroxylase were measured in the granuloma 4, 8 and 12 days after cotton pellet implantation. At the same time "collagen-like" protein was determined in the serum of the animals. The enzyme activity was statistically significant lower in the granuloma of animals on iron deficiency than in the granuloma of the comparable groups on normal diet. Statistically significant higher concentration of neutral salt soluble collagen was found 8 and 12 days after cotton pellet implantation in the group on iron free diet. There was no significant difference as to the serum levels of "collagen-like" protein in serum.

Anemia, Hypochromic↗
PubMed1978

Ophthalmologic toxicity after cis-dichlorodiammineplatinum(II) therapy.

Two cases of apparent ophthalmologic toxicity which occurred during treatment with cis-dichlorodiammineplatinum(II) (DDP) are described. In the first case, a patient with testicular carcinoma developed papilledema after three courses of DDP and adriamycin therapy. In the second case, a patient with breast cancer developed retrobulbar neuritis after three courses of DDP therapy. The differential diagnosis and possible explanation for these toxic effects are discussed.

Aged↗
PubMed1977

[The treatment of metastasizing hypernephroid (renal cell) carcinoma with medroxyprogesterone acetate (Clinovir) (author's transl].

15 patients with distant metastases of hypernephroid carcinoma were treated with medroxyprogesterone acetate (usually 300 mg daily by mouth). In 5 patients the metastases showed slower growth, remained stationary or regressed somewhat under this treatment. But a complete regression of metastases could not be obtained. The treatment was very well tolerated. Monitoring the transaminases and alkaline phosphatase during treatment is to be recommended.

Adenocarcinoma↗
PubMed1975

Functional heterogeneity of the transport iron compartment II. In vivo differences between transferrin iron binding sites, and in vitro interbinding site iron exchange.

First, an 80% 59Fe-saturated transferrin solution was exposed to reticulocytes to reduce its iron content. Iron-donating activity of the supernatant was subsequently compared to that of a fresh preparation equal in iron and transferrin concentration; it was found significantly reduced, but gradually improving in presence of 10(-3)M citrate. Second, two transferrin solutions saturated with 59FeCl3 or 56FeCl3 were exposed to reticulocytes and resaturated adding the opposite iron species. These preparations were injected into rats and the 59Fe plasma disappearance rate was followed; the 59Fe added after reticulocyte exposure was cleared more rapidly. It is concluded that citrate ions mediate interbinding site iron exchange. Further, iron distribution among binding sites is important for tissue iron delivery.

Animals↗