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Biomedical subjects

D H Wilson

Publications and source records attributed to D H Wilson.

126 records · Page 7Linked to original sources
PubMed1972

Treatment of soft-tissue injuries by pulsed electrical energy.

Twenty pairs of patients matched for sex, age, weight, and degree of trauma were treated either with an active Diapulse machine emitting pulsed, high-frequency electrical energy or with a non-active placebo machine. They were examined for swelling, pain, and disability before treatment and after three days under double-blind conditions. The results show that the pulsed, high-frequency electrical treatment has a definite biological effect on recently injured soft tissues, especially in the reduction of pain and disability.

Ankle Injuries↗
PubMed1966

Benign intracranial hypertension with particular reference to its occurrence in fat young women.

Benign intracranial hypertension (pseudotumor cerebri), a syndrome common to a number of disorders, is characterized by headaches and blurred vision. The patient is alert and has papilledema without localizing signs. Air studies show normal ventricles under increased pressure. The authors describe 61 consecutive cases of this pseudotumour, 48 of which were in fat young women, and propose that this group represents a clinical entity that has hitherto received little attention.In these 61 patients, 40 complete-exchange pneumoencephalograms showed normal ventricles, normal fluid volume and prominent cortical sulci. In 32, subtemporal decompression resulted in prompt and lasting relief. Three patients had late convulsive seizures after surgery. Seven patients had nasal quadrantanopsias, the implications of which are discussed. The authors believe that the high intracranial pressure in this condition is due to cerebral hyperemia, not brain edema. Further investigation will perhaps demonstrate a relationship between obesity, vascular dilatation and increased intracranial pressure.

Adult↗
PubMedDate not supplied

A controlled study comparing the conventional treatment of idiopathic anorectal abcess with that of incision, curettage and primary suture under systemic antibiotic cover.

The treatment of anorectal abscess by deroofing and packing on an initial inpatient basis has been compared in a controlled trial with that of incision, curettage and primary suture under systemic antibiotic cover in the Accident and Emergency Department. Over a three-year period 219 patients with anorectal abscess were randomly allocated to one or other treatment and subsequently followed up in a rectal clinic. In terms of the time taken for complete healing and the periods lost from work postoperatively, the method of incision, curettage and primary suture under systemic antibiotic cover was found to be significantly superior, without any increased risk of recurrence of the abscess or of subsequent fistula formation.

Abscess↗
PubMedDate not supplied

Dynamic light scattering investigations of RecA self-assembly and interactions with single strand DNA.

Dynamic light scattering (DLS) measurements were performed on self-assembled solutions of RecA as a function of assembly time under strand exchange ionic strength conditions (10 mM MgCl2, 65 mM NaCl, 10 mM Tris-HCl, pH = 7.5, 1 mM DTT, 3-4 microM RecA) in the absence of ATP. These measurements yield distributions of the translational diffusion coefficients of the changing populations of assembling protein species. Interpretations of results of DLS measurements are made in terms of model hydrodynamic calculations that indicate, under the solution conditions employed, the smallest fundamental quaternary subunit of RecA is a hexamer in a toroidal or lock-washer configuration. Interactions of M13mp19 circular single strand DNA (ssDNA) with RecA assembled to different stages were also investigated. Additions of ssDNA to self-assembled solutions of RecA acts to dissociate the associated structures into hexamer subunits. However, the effect of ssDNA on assembled RecA is highly dependent on the RecA self-assembly state. The longer the assembly time, the less reversible the self-assembled structures of RecA become. Binding isotherms of titrated mixtures of ssDNA with RecA self-assembled to various stages were also determined. Evaluated dissociation constants of RecA/ssDNA complexes were found to increase with increases of the associated state of RecA. These results strongly suggest that, under the solvent conditions employed, the active ssDNA binding form of RecA is a hexamer.

Adenosine Triphosphate↗
PubMedDate not supplied

Peripheral nerve grafting in the spinal cord: a histological and electrophysiological study.

Excision of the dorsal columns was used to create a lesion in the spinal cord. The defect was bridged using a peripheral nerve graft. Silver staining showed the grafts being invaded by axons. Neuronal tracing by injecting horseradish peroxidase into the graft showed the origin of these fibres to be in dorsal root ganglia and in the grey matter of the lumbar cord. All of the animals studied showed horseradish peroxidase staining of neurones in the grey matter of the lumbar cord caudal to the graft. Five of the animals had staining of the dorsal root ganglion cells. Electro-physiological assessment was performed 5 to 6 months following the grafting procedure. Evoked potentials were recorded from the graft in six animals and from the dorsal columns above the graft in six animals.

Animals↗
PubMedDate not supplied

Audiological manifestations in "split brain" patients.

Traditional peripheral hearing tests (pure-tone thresholds, speech reception thresholds, and speech discrimination) and selected "central" hearing tests were administered to three commissurotomized patients. One patient was tested both pre-and postoperatively, whereas the remaining two were tested only postsurgery. Results indicated that commissurotomy had no apparent effects on performance on the peripheral tests. However, various tests in the central battery showed definite abnormal results. Most significant were the results from dichotically presented speech stimuli which repeatedly showed total absence of responses for stimuli presented to the left ear. Additional experimentation indicated this monaural deficit could be overcome by reducing the intensity level of right ear stimuli. Results for low-redundancy, monotically presented speech stimuli also indicated a left ear deficit; however, these results were not as consistent as the dichotic data.

Adolescent↗
PubMedDate not supplied

The surgery of cervical disk disease: new perspectives.

Current trends in the surgical treatment of cervical disk disease, when compared with those of the 1960s, have been unimpressive. There is an ongoing refinement of anterior procedures, which seem to be effective for both myelopathy and radiculopathy, ranging from simple diskectomy and/or fusion to variously radical anterior decompressions. This refinement has demonstrated that however simple or radical the anterior procedure is, the results seem to be the same and that bone grafting is not necessarily critical to success. Posterior procedures, both for root exploration and spinal cord decompression, have fewer advocates but remain important procedures. Their magnitude relative to that of anterior surgery and the lack of refinement of laminectomy over the past 50 years probably accounts most for the preference for anterior surgery. Anterior and posterior disk surgery both have their place based on a surgion's preference. One can expect 80 to 100% acceptable results with radiculopathy and 50 to 70% with myelopathy.

Cervical Vertebrae↗