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Biomedical subjects

D H Rice

Publications and source records attributed to D H Rice.

At least 109 records · Page 6Linked to original sources

Use of polytetrafluorinated ethylene compound in peripheral nerve grafting. An experimental study.

The suitability of polytetrafluorinated ethylene compound (Gore-tex) tubing in peripheral nerve grafting was studied using a rat sciatic nerve model. Thick-walled (0.36 mm) tubing was compared with thin-walled tubing (17 mm). Thin-walled tubing gave a favorable functional and microscopic result in five of seven animals, while thick-walled tubing gave a favorable graft result in three of six animals. The results achieved with the thin-walled tubing were comparable to those achieved using nerve grafts and vein interposition grafts.

Animals↗

The use of autogenous vein for nerve grafting.

The use of autogenous femoral vein to graft a resected segment of sciatic nerve in 10 rats suggests that autogenous vein can serve as a satisfactory nerve graft conduit. Scar tissue within the vein or distal nerve was minimal.

Animals↗

Rhabdomyosarcoma of the head and neck.

A retrospective review of all cases of rhabdomyosarcoma seen at UCLA was done. Survival prior to the advent of cyclic multidrug chemotherapy was compared to survival with this therapy. In the latter group, unlike other published series, survival was 100% better with gross total removal of disease as compared to biopsy only. All received at least 5000 rads. Fifteen percent presented with regional nodal metastases. However 75% of these also had intracranial extension and all died. An additional 19% developed late regional nodal metastases; 80% of these also developed systemic metastases and all died. Survival in the absence of nodal disease was 41%.

Adolescent↗

Osteosarcoma and chondrosarcoma of the head and neck.

Osteosarcomas and chondrosarcomas are rare malignant neoplasms in the head and neck. Eighteen cases seen at the UCLA Center for the Health Sciences are reviewed. Osteosarcomas of the maxilla tended to occur a decade later than those of the mandible or cranial bones. Several followed prior irradiation for retinoblastoma. Complete excision offers the only realistic chance for cure. Adjuvant therapy has little to offer these patients at this time.

Adolescent↗

Advances in diagnosis and management of salivary gland diseases.

Salivary glands may be involved in a wide variety of diseases, which may be broadly grouped into (1) inflammatory, (2) noninflammatory, nonneoplastic and (3) neoplastic categories. Most inflammatory and noninflammatory, nonneoplastic diseases should be managed conservatively and symptomatically. The common exceptions are first-arch branchialcleft cysts and calculi. Neoplastic lesions always require resection if that is feasible. For benign tumors, simple excision with a cuff of normal tissue around it will usually suffice. The prevailing trend for treatment of malignant neoplasms is conservatism. No longer is the facial nerve routinely sacrificed. The resection done is dictated by the tumor size and the facial nerve is spared unless directly invaded. Postoperative radiation therapy is increasingly used.

Cysts↗

The nerve-muscle pedicle. A visual, electromyographic, and histochemical study.

The nerve-muscle pedicle was studied in dogs using visual, electromyographic, and histochemical means. All methods failed to show evidence of reinnervation. It would appear that the nerve-muscle pedicle operative procedure causes fibrosis and lateral displacement of the vocal cord with a subsequent improvement in the airway. It thus functions as a minimal arytenoidopexy.

Animals↗

Carcinoma of the tongue in persons younger than 30 years of age.

Squamous cell carcinoma of the tongue in young people is a rare disease. The usual causal agents associated with this disease in older patients may not be operative in this younger age group or may involve a greatly reduced latency. Failure to perform a biopsy of tongue lesions in young patients often leads to late diagnosis. The prognosis is similar, stage for stage, as for older patients. Thirteen cases of squamous cell carcinoma of the tongue occurred in patients younger than 30 years of age. Their clinical appearance, stage and histologic state, treatment, and survival are discussed. A high index of suspicion leading to early diagnosis and systematic adequate treatment are needed to alter the unfavorable prognosis of this lesion.

Adolescent↗

Restoration of physiologic vocal fold abduction with the ansa cervicalis nerve.

An attempt was made to restore physiologic abduction of the vocal fold using the ansa cervicalis nerve. In adult dogs, the ansa cervicalis nerve was anastomosed to the abductor branch of the recurrent laryngeal nerve. In the four surviving dogs, abduction of approximately 50% to 70% of normal was restored synchronous with inspiration. This technique seems to work almost as well as the phrenic nerve and is easier to perform.

Animals↗

Rhabdomyosarcoma of the head and neck.

A retrospective review of all cases of rhabdomyosarcoma seen at UCLA was done. Survival prior to the advent of cyclic multidrug chemotherapy was compared to survival with this therapy. In the latter group, unlike other published series, survival was 150% better with gross total removal of disease as compared to biopsy only. All received at least 5000 rads. Fifteen percent presented with regional nodal metastases. However 75% of these also had intracranial extension and all died. An additional 19% developed late regional nodal metastases. Eighty percent of these also developed systemic metastases and all died. Survival in the absence of nodal disease was 41%. This is the first study to address the influence of regional nodal metastases, early and late on the outcome of treatment. In rhabdomyosarcoma of the head and neck, regional nodal metastases at any time implies a grave prognosis and more seriously adversely affects the progress than it does in squamous cell carcinoma in adults.

Adolescent↗

Repair of subglottic stenosis with a free perichondrial graft.

Previous work with dogs has shown that a free perichondrial graft will predictably produce new cartilage when placed in the trachea. In the absence of a wound infection, the production of cartilage was predictable although the amount of cartilage varied. The present study sought to determine if enough cartilage could be produced to correct an acquired subglottic stenosis. In all dogs in whom a wound infection did not occur, enough cartilage was produced to support and maintain the subglottic lumen.

Animals↗

The use of povidone-iodine to prevent postoperative wound infection.

A retrospective analysis of the use of povidone-iodine in the prevention of postoperative wound infections was done. Fifty consecutive patients who underwent major head and neck procedures involving the oral cavity or pharynx were studied. Time-honored techniques were used, including underflap suction and perioperative antibiotics. Immediately before skin closure, the operative wound was irrigated with povidone-iodine solution. There was one minor postoperative infection, with no fistulas, wound dehiscence, or other complications. The single wound infection cleared with simple drainage. This infection rate of 2% compares favorably with those previously reported in the literature.

Humans↗

Computerized tomography with simultaneous sialography in evaluating parotid tumors.

In an effort to improve on the amount of preoperative information obtainable, computerized tomography was combined with contrast sialography in the evaluation of parotid masses. Experience to date is limited to 17 patients, but this combination of techniques seems to demonstrate clearly the margins of the tumor, whether or not there is extraparotid extension, whether the mass is medial or lateral to the facial nerve, and whether or not the mass will hamper access to the main trunk of the facial nerve.

Adult↗

Cranial complications of frontal sinusitis.

Complications of frontal sinusitis are potentially serious. The best prevention is adequate antibiotic treatment of acute sinusitis or of the acute exacerbation of chronic sinusitis. Intracranial complications include extradural, subdural and brain abscesses, meningitis and cavernous sinus thrombophlebitis. Bony complications include localized or spreading osteomyelitis. Surgical intervention is often required to prevent unacceptable mortality.

Adult↗