Biomedical subjects
Publications and source records attributed to D Grigoriu.
Since 1969, 79 cases of fungal maxillary sinusitis have been diagnosed. Forty-nine were due to Aspergillus fumigatus. There were no underlying diseases which depressed cellular immunity and no patient was receiving immunosuppressive drugs or corticosteroids. Most patients had received antibacterial therapy before the appearance of FMS. Treatment was by surgery, nystatin and econazole.
Demonstration of some cases of mycoses caused by opportunistic fungi.
Since 1969, 600 patients suffering from maxillary sinusitis have been systematically controlled clinically as well as mycologically. We discovered 81 cases of maxillary sinusitis (13,4%). Aspergillus fumigatus and Candida albicans were the most frequently isolated fungi. Three clinical forms could be distinguished: (1) a muco-purulent form (35 cases); (2) a budding and/or caseous form (22 cases), and (3) a pseudotumoral form (24 cases). 42 patients treated with a 1% econazol (base) solution were healed.
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Otomycosis is a relatively frequent disorder (21.7% of the cases of external otitis) of fungi origin. Otomycoses can be discriminated from bacterial otitis by the following symptoms: itching, absence of otalgy, discharge and negative response to different local antibiotic therapies. Our study involves 148 cases of otomycosis and their therapy. Recovery was obtained in approximately 10 days.
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The antifungal activity of econazole nitrate (Pevaryl) can be demonstrated by means of a new test -- called contact test -- developed by the authors. This method of assessing the fungicidal activity was tested in nine patients and found to be satisfactory.
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A 61-year-old patient presented with an eczematous patch on the left wrist, suspect of a contact dermatitis to his watch. This lesion did not respond to the usual topical treatment. On the contrary, new lesions appeared on both forearms. A fungous culture was positive and confirmed the diagnosis of tinea circinata. Appropriate treatment allowed a complete cure within 1 month.
7 Cases of vesiculo-bullous erythrasma of the feet are reported. Wood's light, microbiology and histology permit to separate this entity from dysidrotic eczema and dermatophytosis.
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