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Biomedical subjects

D Gordon

Publications and source records attributed to D Gordon.

At least 505 records · Page 28Linked to original sources

Prognostic significance of portal pressure in patients with bleeding esophageal varices.

Portal pressure was determined in 76 patients during acute bleeding varices, and the degree of portal hypertension was related to the cessation or noncessation of hemorrhage with nonoperative management. A direct relationship between the severity of hemorrhage and the degree of portal hypertension was established. It is suggested that portal pressure be determined as soon as feasible when bleeding varices are suspected and that other causes of hemorrhage be carefully excluded. The obtained data are of great prognostic significance and might be helpful in planning the course of therapy in these individuals.

Adult↗

Reticular neovascularity in malignant and inflammatory renal masses.

Experienced angiographers were asked to differentiate malignancy from inflammatory disease on arteriograms of 37 renal masses containing fine reticular neovascularity, as opposed to the coarser, more irregular vessels typical of hypernephroma. The rate of accuracy was only 58%. Distribution of vessels chiefly around the periphery of the mass was associated with a diagnosis of inflammatory disease in all 6 patients with this finding; this was the sole criterion which proved to be helpful in making the distinction. The authors feel that when arteriography reveals reticular neovascularity, differentiation between malignant and inflammatory renal masses may be difficult or impossible and that the term "tumor vascularity" should be avoided in such situations.

Diagnosis, Differential↗

Dynamic studies with 99mTc-HEDP in normal subjects and in patients with bone tumors.

Blood clearance, urinary excretion, and spinal uptake of 99mTc-HEDP have been measured in ten normal control subjects. Blood clearance from 15 min is biexponential. Approximately 70% of the administered activity was excreted in the urine within 6 hr of injection. Spine-to-background ratios rise sequentially with time. Net normal bone uptake rises little after 2 hr and improved visualization of the normal skeleton therafter is due to reduction of blood background activity. In 13 patients with bone tumors, direct measurement of diphosphonate uptake by the tumor-involved and corresponding normal bone showed a continued rise in diphosphonate levels in the tumor-involved bone due to increased metabolic activity.

Adult↗