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Biomedical subjects

D Gendrel

Publications and source records attributed to D Gendrel.

190 records · Page 11Linked to original sources
PubMedDate not supplied

[Congenital adrenal hyperplasia due to blockade of 3-beta-hydroxysteroid dehydrogenase].

Five cases of congenital 3 beta-hydroxysteroid deshydrogenase deficiency in children are reported: four boys with perineal posterior hypospadias and one girl with clitoromegaly. The salt losing syndrome was clinically overt in only three patients. The main biological character was the very high level of plasma dehydroepiandrosterone (DHA) with an elevated DHA/delta 4 androstenedione ratio. The 17 alpha-OH progesterone, though in normal biosynthesis of glucocorticoids being produced beyond the enzymatic block, was raised, but this apparently paradoxical observation may assist making the diagnosis. Deficient production of testosterone was demonstrated in the prepubertal boys by absence of postnatal rise in plasma testosterone or a decreased reponse of plasma testosterone to chorionic gonadotrophin. It is concluded that deficiency of 3 beta-hydroxysteroid deshydrogenase, now easily recognizable with the use of plasma steroids radioimmunoassay, is probably less rare than was apparent with the use of urinary steroid estimations.

3-Hydroxysteroid Dehydrogenases↗
PubMedDate not supplied

[Breast-feeding and intestinal parasites].

The extent of intestinal parasitic infection was determined using 4 methods of fecal examination in 400 Gabonese infants aged 0.5 to 24 months (86 exclusively and 151 partially breast-fed and 163 artificially fed) and in 170 of their mothers in an African urban community. Parasitic prevalence was the same in the stools of the mothers from the 3 infant groups, providing evidence for the same level of exposure to parasites in all infants. Exclusively and partially breast-fed infants excreted parasites in numbers significantly lower than artificially fed infants of the same ages, during the first and the second years of life. This antiparasitic activity of human milk concerned mostly Giardia and ascaris, was not exclusively due to a decreased exposure to parasites in breast-fed infants and did not seem exclusively antibody-mediated; the role of lipids is possible.

Animals↗
PubMedDate not supplied

[Acute gastroenteritis and breast feeding in Gabon. Preliminary results].

76 diarrheic infants (from 15 days to 2 years) had a stool examination for rotavirus (ELISA method) and a stool culture and were classified according to breast feeding or not. This study was performed in a semi-urban region (Haut-Ogooué, Gabon). The preliminary results suggest a protection by breast feeding against rotavirus and enteropathogenic bacteria, rapid elimination of diarrheic agents may be facilitated by human milk.

Acute Disease↗
PubMedDate not supplied

[Activity of the hypophyso-gonadal axis in premature boys].

Postnatal evolution of testosterone, LH and FSH plasma levels was studied in 30 premature boys. Increase in LH and testosterone levels at the age of 2 months was found in these children as in full-term children; both parameters were positively correlated. Activation of hypophysogonadal function in premature seems to depend on postnatal age and not on gestational age.

Follicle Stimulating Hormone↗
PubMedDate not supplied

[Low serum thyroxin and thyroxin-binding globulin in neonatal respiratory distress (author's transl)].

Measurements of thyroxin (T4), thyroxin-binding globulin (TBG) and TSH were carried out in 34 full-term newborns, 21 prematures and 11 neonates with respiratory distress (6 with hyaline membrane disease) at 5 days of age. In cases with neonatal respiratory distress and to a lesser extent in prematures, low T4 due to a decrease of TBG was found, TSH being identical in all groups. The positive correlation between TBG and transferrin suggests a disturbance in hepatic synthesis. The authors conclude that, in cases with neonatal respiratory distress, low T4 does not mean hypothyroidism and does not require a treatment, provided TSH remains within normal limits.

Humans↗