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Biomedical subjects

D G Clark

Publications and source records attributed to D G Clark.

At least 91 records · Page 5Linked to original sources
PubMed1974

Pathways of glyceride glycerol synthesis.

Isolated rat liver parenchymal cells were incubated for various periods with [U-(14)C,2-(3)H]glycerol and the radioisotopic yields in the major products were determined, as well as the (3)H/(14)C ratios in glyceride glycerol and intracellular glycerol phosphate. Under the conditions used (0.1mm-glycerol+10mm-l-lactate or 10mm-glycerol as substrates), only small differences were found between these (3)H/(14)C ratios. The results suggest a minor role for a pathway of glyceride glycerol synthesis involving reduction of acylated dihydroxyacetone phosphate, under these experimental conditions.

Acetone↗
PubMed1973

Role of inorganic nitrite in methaemoglobin formation after nitrate ester administration to the rat.

1. Methaemoglobin is rapidly formed during the incubation of rat red cells with inorganic nitrite, whereas ethylene glycol dinitrate at a higher concentration has little effect.2. The concentrations of blood inorganic nitrite in the rat after ethylene glycol dinitrate or glyceryl trinitrate injection can be reproduced by the infusion of nitrite. The methaemoglobin formed after ethylene glycol dinitrate or glyceryl trinitrate injection is equivalent to that produced from nitrite infusions simulating its formation from the nitrate esters.3. It is concluded that methaemoglobin arising from nitrate ester administration is formed principally by the action of the metabolite inorganic nitrite.

Animals↗
PubMed1973

Correlation of the cardiac sensitizing potential of halogenated hydrocarbons with their physicochemical properties.

The cardiac sensitizing potencies of a range of 14 halogenated hydrocarbons were assessed in conscious dogs by comparing the partial pressures (Pcs) needed to sensitize the heart to adrenaline. These were found to be directly related to their saturated vapour pressures (Ps) and the ratio Pcs/Ps was approximately constant although the values of partial pressures differed nearly 700-fold. It is suggested that cardiac sensitization is probably a structurally non-specific action and may be regarded as another example of physical toxicity.

Anesthetics↗