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Biomedical subjects

D F Harrison

Publications and source records attributed to D F Harrison.

At least 55 records · Page 3Linked to original sources
PubMed1981

Radical resection for cancer of the hypopharynx and cervical oesophagus with repair by stomach transposition.

The results of 58 consecutive cases of pharyngolaryngo-oesophagectomy and pharyngogastric anastomosis are presented. The Grey Turner technique is used, but modified by adding bilateral chest drainage established by guidance from below the diaphragm and a jejunostomy. The immediate postoperative therapy management of hypocalcaemia with calcium gluconate and long term control with calciferol is described. An overall 3-year survival rate of 29 per cent has been obtained. Seven patients survived longer than 7 years, the longest living over 10 years. The authors conclude that, with careful management this technique is within the compass of competent surgeons with good facilities and should be the surgical treatment of choice for these difficult tumours.

Adult↗
PubMed1981

Pleomorphic salivary gland adenomas of the parapharyngeal space. Review of nine cases.

Nine cases of pleomorphic salivary gland adenomas of the parapharyngeal space are reviewed. In the discussion which follows we show that five of these tumours were situated medial to the superior constrictor muscle and arose within pharyngeal mucosa. We also outline our views on the management of pleomorphic salivary gland adenoma of the parapharyngeal space with particular reference to biopsy, surgical excision and post-operative radiotherapy.

Adenoma, Pleomorphic↗
PubMed1981

Nurses and disasters.

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Adaptation, Psychological↗
PubMed1980

Correspondenc.

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Otolaryngology↗
PubMed1980

Fear of cancer.

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Animals↗
PubMed1979

Surgical management of hypopharyngeal cancer. Particular reference to the gastric "pull-up" operation.

Between the years 1965 to 1977, 58 patients with advanced hypopharyngeal squamous carcinoma were treated by pharyngolaryngoesophagectomy and total thyroidectomy. Operative mortality for potentially curable cases was 8.6%, with a crude three-year survival rate of 29% for all cases. Mortality was 37% for patients with postcricoid tumors. Long-term management was uncomplicated except for calcium metabolism; two patients died from nephrocalcinosis secondary to return of circulating parathyroid hormone. I discuss the role of this operation in the successful treatment of hypopharyngeal cancer.

Adult↗
PubMed1979

Intrinsic weakness of the TNM system for classification of laryngeal cancer.

All tumor classifications are compromises based upon clinical or radiological evaluation with little concern for histology and intrinsic errors in application. Laryngeal cancer is no exception, and the present UICC system is critically examined with the intention of highlighting such deficiencies and relating them where possible to prognosis. Possible lymph node and systemic metastases are also considered in the light of personal experience and any intrinsic weaknesses evaluated in relation to variations in published cure rates. No better system is proposed, for at least this system encourages more accurate recording of clinical assessment.

Carcinoma, Squamous Cell↗
PubMed1978

Rehabilitation problems after pharyngogastric anastomosis.

Fifty-three patients had pharyngolaryngoesophagectomy during the years 1965 to 1976 for lower hypopharyngeal or cervical esophageal cancer. The operative mortality--defined as the percent of patients who died within seven days of operation--was 7.5%, which is reduced to 5.6% if one patient with inoperable disease is excluded. Twenty-eight percent of patients survived for longer than one year, and there have been no problems with swallowing. Communication is possible in every patient who possesses good motivation, but the problems of long-term management of calcium metabolism still require attention.

Calcium↗
PubMed1977

Saccular mucocele and laryngeal cancer.

Saccular mucoceles are a definite entity and probably occur more frequently than is supposed. Confusion with internal laryngoceles is possibly due to lack of understanding of basic anatomy and physiology. A 49-year-old man had a saccular mucocele that was possibly associated with laryngeal cancer, although a definitive diagnosis was only made two years later. The laryngectomy specimen was serially sectioned and showed an internal laryngocele on the side that was not operated one. This patient remains alive and well four years after excision of a T4 carcinoma, although a unilateral radical neck dissection was performed two years ago.

Animals↗
PubMed1977

Resection of the manubrium.

Direct exposure of the superior mediastinum is essential when resecting subglottic tumours of the larynx, neoplasms of the cervical trachea or cervical oesophagus. This facilitates low resection of the trachea and clearance of the paratracheal nodes. This may best be carried out by removal of most of the manubrium sterni and both sternoclavicular joints and this operation has been performed in 22 patients with minimal morbidity or long term disability.

Esophageal Neoplasms↗