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Biomedical subjects

D F Harrison

Publications and source records attributed to D F Harrison.

At least 37 records · Page 2Linked to original sources
PubMed1988

Craniofacial resection for tumors of the nasal cavity and paranasal sinuses.

The combined approach for resection of tumors of the nose and paranasal sinuses is well established. The technique has been considerably modified, resulting in an operation that combines good access, sound oncologic resection with excellent cosmesis, and a low postoperative morbidity rate for conditions that have been associated hitherto with an extremely poor prognosis. A 9 year experience with 92 patients is presented. Long follow-up confirmed the initial results, suggesting an improved survival rate in patients with potentially curable disease. An increasing number of large benign tumors, which would previously have been considered inaccessible, are now being resected. Herein, the role and accuracy of preoperative investigations such as computerized tomography and magnetic resonance imaging are evaluated, and the cosmetic implications associated with long-term survival, particularly in children, is considered. The many advantages of craniofacial resection recommend it as the treatment of choice for tumors of the nose and paranasal sinuses, and the versatility of the technique allows its application to tumors arising in adjacent areas.

Adolescent↗
PubMed1988

A specialist institute looks to the future.

A specialized institute has unique problems relating to its responsibility for teaching, research and clinical care. In the 40 years of its existence it has played a considerable role in the development of the specialty in the United Kingdom, advancing knowledge in all fields--particularly head and neck oncology and audiological medicine. The threat to its associated specialist hospital and to its own future because of severe cuts may result in far-reaching decisions regarding its future role.

Academies and Institutes↗
PubMed1988

Classification: the great deception.

The linchpin of oncologic statistics might well be thought to be classification based upon the hope that comparisons of natural history and treatment regimes could be compared and controlled worldwide. Many such systems exist for sites within the head and neck; all possess varying degrees of intrinsic error--usually unquantified! A review of three sites by an experienced clinician highlights some of these deficiencies together with their likely significance. The conclusion is reached that although encouraging better recording of clinical and radiologic assessment, cancer statistics based upon existing classification systems can best be compared with a pyramid perched precariously upon its apex!

Head and Neck Neoplasms↗
PubMed1987

The natural history, pathogenesis, and treatment of juvenile angiofibroma. Personal experience with 44 patients.

The lessons learned from the personal care of 44 male patients suffering from juvenile angiofibroma are discussed with reference to natural history, pathogenesis, and principles of management. Many of the doctrines often accepted as based on factual evidence are discussed in relation to actual experience. In this manner, a rational view of this interesting but unusual condition is presented in the hope that some of the more bizarre opinions may now be abandoned to the benefit of future patients.

Adolescent↗
PubMed1987

Midline destructive granuloma: fact or fiction.

Although differentiation of Wegener's granulomatosis from other destructive midline lesions is now clearly recognized by clinicians and pathologists, confusion persists regarding the management of what has erroneously been called "lethal midline granuloma." The experiences of 36 patients with destructive midline granuloma supports the view that probably all are manifestations of malignant lymphoma and should be treated as such. Although radical dosage radiotherapy will control most local lesions, dissemination of lymphoma may still occur despite absence of systemic disease at initial diagnostic work-up. Subsequent control with cytotoxic drugs is frequently unsuccessful, and it is suggested that chemotherapy should be given routinely to every patient with primary nasal lymphoma and possibly to those with polymorphic reticulosis or necrosis with atypical cellular exudate (NACE).

Adult↗
PubMed1985

Idiopathic ulceration of the hypopharynx.

At least three clinical variations of idiopathic ulceration of the oropharyngeal cavity are recognized. Major (or giant) aphthous ulceration is uncommon but may affect the hypopharynx producing severe pain, dysphagia, and severe scarring. Healing with systemic prednisolone may require large and prolonged dosage. In 7 out of 14 patients with hypopharyngeal ulceration gastrostomy was performed to assist nutrition and by-pass the cricopharyngeal region in an attempt at reducing subsequent scarring.

Adolescent↗
PubMed1984

Bullet wounds of the larynx and trachea.

Bullet wounds involving larynx or trachea frequently prove fatal unless the airway is maintained soon after injury. With modern high-velocity bullets tissue damage is severe and injuries may be multiple. Six cases of high-velocity bullet wounds survived initial injury. The sequelae of the damage to larynx or trachea is discussed and in three patients total laryngectomy was necessary.

Adolescent↗