Control of an acute Klebsiella pneumoniae infection in a rhesus monkey colony.
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Biomedical subjects
Publications and source records attributed to D E Hunt.
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Bacterial colonies grown on membrane filters and transferred to plates of inhibitor-containing medium decrease in number of total viable colony-forming cells. The decrease in viable cell count occurs in direct proportion to the concentration of inhibitor present and the length of time the colonies are exposed to the inhibitor, suggesting that the kinetics of cell kill approximate a first-order chemical reaction.
Methyl-5(or 4)-(3,3-dimethyl-1-triazeno)-imidazole-4(or 5)-carboxylate was shown to have in vitro antimicrobial activity against gram-positive and gram-negative bacteria, yeasts, filamentous fungi, and algae. Preliminary studies with mice, experimentally infected with Staphylococcus aureus, have shown that this new antimicrobial agent has in vivo chemotherapeutic activity comparable to that observed with penicillin.
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