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Biomedical subjects

D E Hunt

Publications and source records attributed to D E Hunt.

At least 37 records · Page 2Linked to original sources
PubMed1972

In vitro evaluation of actinobolin as an antibiotic for the treatment of periodontal disease.

Actinobolin was evaluated in vitro by a paper disc-agar diffusion method for inhibitory activity against mixed microbial cultures obtained from patients with periodontal disease and against pure bacterial cultures tentatively identified as strains of Bacteroides melaninogenicus, Fusobacterium fusiforme, Leptotrichia buccalis, and Veillonella parvula. Every culture tested was inhibited to some degree by actinobolin. These observations suggest that actinobolin may be effective in the treatment of periodontal disease.

Anaerobiosis↗
PubMed1970

Microbiological assay for estimating salivary concentrations of the cariostatic antibiotic Actinobolin.

A logarithmic-ratio microbiological assay has been developed for the estimation of concentrations of actinobolin (or inhibitory equivalents) in human saliva. The utility of this assay has been demonstrated by presenting data that show concentrations of this antibiotic (or inhibitory equivalents) detected in saliva or saline after incubation at 37 C for periods as long as 6 hr. The results of some statistical analyses of the assay data have been included.

Anti-Bacterial Agents↗
PubMed1969

Use of fast green in agar-diffusion microbiological assays.

Microbiological assay plates containing agar stained with fast green and inoculated with test microorganisms could be readily distinguished from unstained seeded agar plates. The boundaries of zones of growth inhibition were more sharply defined in those plates which contained stained agar.

Agar↗
PubMed1968

Antimicrobial evaluation of 1-methyl-3-nitro-1-Nitrosoguanidine.

1-Methyl-3-nitro-1-nitrosoguanidine was shown to have in vitro antimicrobial activity against fungi and gram-positive and gram-negative bacteria; it was also shown to have in vivo activity in mice experimentally infected with Staphylococcus aureus or Escherichia coli comparable to that observed with penicillin or streptomycin sulfate.

Animals↗
PubMed1968

A microbiological assay for estimating concentrations of camptothecin lactone in mouse tissues.

The marked sensitivity of the yeast Hansenula wingei NRRL Y-2340 strain 5 to a new antineoplastic alkaloid served as the basis for a logarithmic-ratio microbiological assay which has been developed for the estimation of concentrations of camptothecin lactone (or cytotoxic equivalents) in tissues of mice. The utility of this assay has been demonstrated by presenting data which show the concentrations of camptothecin lactone (or cytotoxic equivalents) detected in various tissues of mice at intervals following intraperitoneal injection of a 1 or 0.5 ld(10) dose of this drug.

Alkaloids↗