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Biomedical subjects

D Dubois

Publications and source records attributed to D Dubois.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Acute pulmonary edema in carbon monoxide poisoning. Prognostic effect].

285 patients affected by carbon monoxide poisoning were admitted in our intensive care unit over a period of two years (from july 1980 to july 1982). 18 patients had a pulmonary edema (P.E.). The occurrence of P.E. was more frequent when coma was grade 2, 3 or 4 (p less than 10(-3]. The acute physiologic score (weighting of physiologic measurements) as proposed by Knauss is higher in patients with P.E. (p less than 10(-2]. However death is never due to P.E.; about 54 patients with coma, 5 died; death is related to neurologic aggravation. Neurologic sequelae are not related to the occurrence of P.E. but to a delay in hyperbaric oxygen therapy. These date show that prognosis of carbon monoxide poisoning is related to neurological status and is not influenced by the occurrence of P.E. when correctly treated and when hyperbaric oxygen therapy is early realized.

Carbon Monoxide Poisoning↗
PubMed1982

Intravenous nitroglycerin in acute respiratory failure of patients with chronic obstructive lung disease, secondary pulmonary hypertension and cor pulmonale.

We have studied the hemodynamic effects of an intravenous single dose of nitroglycerin in 13 patients with secondary pulmonary hypertension and Cor Pulmonale, during the acute course of respiratory failure and under assisted ventilation. We observed a significant decrease in systolic, diastolic and mean pulmonary arterial pressures, and in pulmonary resistance and systolic right ventricular work index, without any change in right or left pre-loads. The systolic arterial pressure decreased slightly, without any change in cardiac index or diastolic pressure. The arterial and mixed venous oxygen contents, and the pulmonary shunting ( Qs/Qt) were unchanged. These results suggest that nitroglycerin may be a useful therapy in patients in the acute stages of pulmonary hypertension resulting from chronic lung disease and under assisted ventilation. In addition, the lack of change in cardiac index, intrapulmonary shunting and oxygen content suggests that this decrease in pulmonary resistance is not linked with any deleterious effect in oxygen transfer.

Acute Disease↗
PubMed1980

[Treatment of hypertension in pregnant women with beta-blockers. 60 cases (author's transl)].

Fifty-nine hypertensive women were treated with beta-blockers during 60 pregnancies. Acebutolol was used in 28 cases, pindolol in 21, atenolol in 10 and propanolol in one. Concomitant administration of dihydralazine was required in 6 cases. In 6 women beta-blockade was started before, and continued throughout pregnancy. Treatment was initiated after the 13th week of gestation in the majority of patients and before the 12th week in two. Twenty women were known to have hypertension long before they became pregnant, and renal disorders were diagnosed in seven. Satisfactory control of blood pressure, with values below 140-90 mmHg, was achieved in 55 cases, and in the same number of cases delivery occurred after 38th week. No clinical or biological side-effects were observed in either mothers or infants. The birth weight was superior to 2500 g in 51 children, including 37 who weighed more than 3000 g. There was only one death in utero. One child born at 35 weeks with multiple malformations and another with meconium ileus also died. Beta-blockers may therefore be safely used to treat most cases of hypertension during pregnancy, provided close supervision is exerted throughout the gestation period.

Adrenergic beta-Antagonists↗
PubMed1977

[Myocardial function of the chronic hemodialysed patient. Evaluation by measurement of systolic time intervals].

Study of myocardial function in chronic haemodialysis patients by the measurement of systolic time intervals reveals an alteration in left ventricular performance. These results are in favour of the hypothesis of a multifactorial cardiomyopathy associated with chronic haemodialysis. In the absent of long standing or severe hypertension, blood pressure levels have no significant influence on systolic interval times, this also applying to the degree of anaemia. The age of the patient and the length of time they have spent on haemodialysis are two cumulative risk factors with respect to altered ventricular performance.

Adolescent↗