Biomedical subjects
Publications and source records attributed to D Dimitrov.
A case with choreoathetoid syndrome is described in a patient with advanced picture of systemic lupus erythematosus. The ineffective cerebroprotective therapy is associated with the grave affection of the deep cerebral structures by he lupus vascuitis. The adequate interpretation of the pathological deviations in the CNS in systemic lupus could contribute to their early diagnosis and timely treatment.
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Thirty two patients with essential hypertension, stage I and II according to WHO classification, were treated according to the following schedule: period A--3 X 1 dragée placebo--3 weeks; period B--3 X 1 dragée placebo + 25 mg hydrochlorothiazide in the morning--6 weeks; period C--3 X 1 dragée isoptin 80 mg + 25 mg hydrochlorothiazide in the morning--6 weeks; period D--3 X 1 dragée placebo--2 weeks. Significant decrease of systolic and diastolic arterial pressure was established during period B as compared with period. A. The addition of isoptin to the treatment during period C led to additional reduction of arterial pressure, with no manifestations of severe adverse effects, as observed in 15,6 per cent of the treated patients. The treatment of essential hypertension with isoptin and esidrex is effective and well tolerated with no reciprocal potentiation of the adverse effects of the two preparations, broadening the possibility of successful treatment of essential hypertension.
Peroral treatment with rhythmonorm (Knoll AG--GFR) with 450 to 900 mg daily was carried out to 38 patients with an average age 52,2 +/- 2,34, with chronic ventricular extrasystole. In 89,50 per cent of the cases, complete inhibition of the ventricular extrasystoles was attained or reduction in their number with greater than 80 per cent, and that result, in 55,26 per cent, was attained within the first days of the treatment. The pulse rate was reduced with 10 per cent on the average by the end of the treatment. Significant changes in cardiac conductivity, arterial pressure and severe adverse effects were not observed. The preparation rhythmonorm is an effective, convenient to take and well tolerated agent for the treatment and prophylaxis of ventricular extrasystoles.
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The results from the administration of verapamyl (isoptine--Knoll GFR) to 30 patients with disturbed heart rhythm are presented, that are grouped as follows: supraventricular paroxysmal tachycardia (SPI)--10; auricular fibrillation (AFi)--8; auricular flutter (AFl)--7; supraventricular extrasystoles (SE)--4, and ventricular extrasystoles (VE)--1. Generally, very good results were obtained, the best effect established with SPT and AFi--rhythm restored in 70 per cent, 50 per cent respectively. Improvement was not attained in a total of 26,7 per cent, adverse effects--hypotony and AV-block were established in 6,66%.
The data from the case histories of 106 patients with myocardial infarction (MI) and diabetes mellitus (DM) from the intensive care unit of III Internal Clinic of the Medical Faculty of the Higher Medical Institute "I. P. Pavlov"-- Plovdiv are interpreted as well as of the same number of patients with myocardial infarction without diabetes mellitus. The authors found a higher percentage of painless forms of myocardial infarction in diabetics, no matter the duration, form and severity of the diabetes. The patients with DM and MI have a slowed down rehabilitation and reverse ECG dynamics. The complications in both groups observed do not differ. Myocardial rupture is significantly more frequent among the females from both groups. High leukocytosis, with shifting to the left, accelerated ESR, high SGOT and LDH activity and hypercoagulemia as well as their slowed down restoration should be admitted--a constellation with an unfavourable prognostic sign, requiring a cautious treatment and a slower rehabilitation.
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