Diagnosis, four hours after chorion biopsy, of female fetus in pregnancy at risk of Duchenne muscular dystrophy.
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Biomedical subjects
Publications and source records attributed to D Coleman.
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According to the 1988 National Household Survey conducted by the National Institute on Drug Abuse, cocaine use among the total population has decreased. This same survey also reported an increase in cocaine use among chronic abusers of the drug. As cocaine use has increased among the abuser population, so has the number of emergency room admissions for cocaine-related complaints; moreover, these patients were admitted with primarily cardiovascular complaints. It is important for the nurse practitioner to recognize the cardiotoxic effects of cocaine abuse. Cocaine abuse should be part of the differential diagnosis in patients with cardiovascular complaints.
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Between January 1973 and February 1975, 77 adults with acute nonlymphoblastic leukemia were treated with a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, prednisone, and vincristine in university-affiliated and private institutions. After 31 patients were treated (regimen 1) the doses of all drugs were significantly increased (regimen 2). Regimes 1 and 2 yielded CR rates of 59% (17 of 29 patients) and 70% (32 of 46 patients) respectively. With regimens 2 the mean number of courses and the median number of days to CR decreased from 3 to 1.4 and from 46 to 29 respectively. Failure to achieve CR was due to persistent leukemia during regimen 1 and fatal infections during regimen 2. With regimen 2 ten of 20 patients (50%) greater than 50 years had CR compared to 22 of 26 patients (85%) less than 50 years. CR rates were similar in community and university institutions.
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