Biomedical subjects
D Campbell
Publications and source records attributed to D Campbell.
Delayed presentation of traumatic splenic arterio-venous fistula.
We report a patient who presented with dyspnoea and was found on examination to have a machinery murmur in the left upper quadrant of the abdomen. The patient had sustained blunt abdominal trauma one year prior to presentation. A diagnosis of splenic arteriovenous fistula was made. The diagnosis and management of delayed presentation of traumatic splenic arteriovenous fistula are discussed.
The political nurse.
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Characterization of the hepatic microsomal mixed-function oxidase enzyme system in miniature pigs.
Hepatic microsomal protein, cytochrome P-450, UDP-glucuronyltransferase, ethylmorphine demethylase, aniline hydroxylase, and aryl hydrocarbon hydroxylase levels were measured in the 2-, 4-, 5-, 6-, and 8-month-old Hanford miniature pig. The activities or concentrations of all of the liver parameters measured had apparently reached their adult plateau level by 2 months of age. The use of the miniature pig in toxicology research programs is discussed.
A race apart: nursing the Aborigines.
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Enhancing critical-thinking skills: faculty-student partnerships in community health nursing.
The enhancement of critical-thinking skills empowers students to participate in the building of healthy environments in a variety of settings. The authors describe the development and implementation of unique classroom strategies emphasizing the use of critical thinking by students, the forging of faculty-student partnerships in community health nursing, and the potential impact of these strategies on the expanding horizons of practice.
Making the most of clinical education.
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The tragic rabies death of an 11-year-old girl.
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AIDS in India.
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Public health on the local level.
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Quality assurance. Talk about teaming up.
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Pay award. Yours disgustedly. Interview by Phil Cohen.
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Physical and emotional abuse in pregnancy: a comparison of adult and teenage women.
A sample of 691 African American, Hispanic, and white pregnant teenage and adult women were interviewed in the prenatal setting. On their first prenatal visit, 182 (26%) women reported physical or sexual abuse within the past year. There were significant differences between the teens and adults, with a higher percentage of teens (31.6%) reporting abuse during the prior year than adults (23.6%). The rate of abuse during pregnancy was 21.7% for teens and 15.9% for adult women. Adult women scored significantly higher than teens on two measures of mental abuse. Mental abuse was significantly correlated with physical abuse for all subjects.
African American women. Disparities in health care.
Healthy People 2000 outlines a vision for attaining improved health care for all Americans. This vision is based on the belief that all people should have opportunities to attain adequate health care. For this to be a realistic goal, health service must move from traditional settings such as hospitals, clinics, and outpatient departments to neighborhood centers, schools, churches, workplace environments and homes. But as the settings become redefined, the populations needing the care must be better understood.
Physical health complaints and the use of outpatient mental health services among those with a mental disorder.
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Phase I study of paclitaxel with oral etoposide in advanced solid tumors.
PURPOSE: This study evaluated dose escalation of paclitaxel administered as a 3-hour infusion after a fixed oral etoposide regimen given daily for 10 days to determine an optimal dose and a toxicity profile for this combination. PATIENTS AND METHODS: Three consecutive cohorts consisting of 29 patients with measurable or assessable advanced solid tumors were treated with paclitaxel by intravenous infusion over 3 hours after receiving etoposide, 50 mg orally twice daily, for 10 days. Cycles were repeated every 28 days. Paclitaxel dose levels were: cohort 1, 135 mg/m2; cohort 2, 150 mg/m2; and cohort 3, 175 mg/m2. RESULTS: Dose-limiting toxicity was observed in cohort 3 in 5 of 12 patients (4 of 12 patients met criteria for myelosuppression and 1 of 12 experienced grade 3 mucositis). No unexpected toxicities were observed, and this regimen was well tolerated. DISCUSSION: Administration of paclitaxel in combination with a prolonged oral schedule of etoposide is feasible and toxicities are manageable. The dose-limiting toxicity of a 3-hour infusion of paclitaxel after 10 days of etoposide given orally was myelosuppression. Recommended doses of this combination for phase II studies are etoposide, 100 mg orally daily for 10 days, followed by paclitaxel at a dose of 150 mg/m2 intravenously over 3 hours, and repeated every 4 weeks.