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Biomedical subjects

D C Moore

Publications and source records attributed to D C Moore.

At least 109 records · Page 6Linked to original sources
PubMed1981

Intercostal nerve block: spread of india ink injected to the rib's costal groove.

Three and five millilitre of india ink were injected bilaterally into the costal groove of the 9th or 10th ribs of 14 cadavers. The spread was observed and the costal groove of the rib injected was dissected, with the one above and one below. Nunn and Slavin's study (1980) of similar injections in two cadavers indicated that an injection of one costal groove blocked not only the intercostal nerve of that groove, but at least the one above and below it. The present study verified the author's previous report that only the intercostal nerve in the costal groove of the rib injected is anaesthetized.

Humans↗
PubMed1981

Serum prolactin and tardive dyskinesia.

The authors correlated the serum prolactin levels of 19 men with tardive dyskinesia, 29 postmenopausal women with tardive dyskinesia, and 21 men without tardive dyskinesia with the variables age, sex, antipsychotic dosage, and severity of illness. All subjects were taking antipsychotic medication. The prolactin levels of the 14 women with severe tardive dyskinesia were significantly higher than those of the 15 women with mild symptoms. The prolactin levels of the 8 men with severe tardive dyskinesia did not differ from those of the 11 men with mild symptoms. The authors discuss the sex-related association between prolactin and severity of tardive dyskinesia in the context of recent animal studies that have examined the effect of prolactin and estrogens on the striatum.

Adult↗
PubMed1981

Celiac plexus block: a roentgenographic, anatomic study of technique and spread of solution in patients and corpses.

Techniques for blocking the celiac plexus were evaluated by conventional posteroanterior and lateral x-rays and computed tomography (CT) in 20 patients with intractable pain due to carcinoma of the pancreas and by determining spread of injected dye at the time of autopsy in three corpses. The results showed that (a) the site for insertion of the needles should not be more than 7.5 cm lateral to the spinous process of a lumbar vertebra, (b) needles should be placed bilaterally, (c) the depth to which needles are inserted is greater than previously recommended, and (d) at least 25 ml of solution should be injected through each needle.

Autonomic Nerve Block↗
PubMed1980

The diagnosis of rapid abnormal involuntary movements associated with fluphenazine decanoate.

Three patients with low grade tardive dyskinesia developed an acute episode of abnormal involuntary movements after a single injection of fluphenazine decanoate. All three patients had their symptoms relieved after treatment with antiparkinsonian medication. The differential diagnosis of these movements is discussed, and a possible animal model for this phenomenon is described.

Benztropine↗
PubMed1980

Identification of a subgroup of tardive dyskinesia patients by pharmacologic probes.

Some patients with tardive dyskinesia fit the cholinergic-dopaminergic imbalance theory, but some do not. In an attempt to study his heterogeneity further, the authors measured the responses of 10 patients with tardive dyskinesia to intravenous challenge doses of drugs that facilitate or inhibit acetylcholine transmission (physostigmine or benztropine, respectively). They then measured the response of these patients to an open outpatient deanol trial. They found that the responses of half of the patients followed the classic theory, 2 responded paradoxically, and 3 responsed inconsistently. They suggest that there is a subgroup of tardive dyskinesia patients who fit the theory but that more research is needed to identify the subgroups who do not.

Acetylcholine↗
PubMed1980

Spinal anesthesia: bupivacaine compared with tetracaine.

A solution of 0.75% bupivacaine (Marcaine) in 8.25% dextrose was compared with a similar solution of tetracaine (Pontocaine), the drug most used for spinal anesthesia in the USA. The study employed a randomized double-blind method and a standardized technique for spinal anesthesia in 435 patients. For perineal and lower extremity surgery, 7.5 mg of the local anesthetic was injected, and for intra-abdominal gynecologic surgery, 12 mg was administered. With the 7.5-mg dose, in only one of 121 patients was anesthesia unsatisfactory when bupivacaine was used; anesthesia was unsatisfactory in 19 of 114 patients when tetracaine was used. With the 12-mg dose, 12 patients given bupivacaine and 14 given tetracaine had unsatisfactory analgesia. With both doses, the motor blockade lasted significantly longer with tetracaine. Epinephrine added to the local anesthetic solution significantly increased the duration of action of both drugs. It also prolonged the duration of postoperative analgesia of tetracaine significantly more than the duration of bupivacaine. Bupivacaine 0.75% in 8.25% dextrose is a safe, reliable local anesthetic solution for spinal anesthesia.

Analgesia↗