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Biomedical subjects

D C Garron

Publications and source records attributed to D C Garron.

53 records · Page 3Linked to original sources
PubMed1978

Significance of genetic factors in Gilles de la Tourette syndrome: a review.

Observations suggesting a genetic basis for Gilles de la Tourette syndrome are reviewed with particular emphasis on the finding of familial aggregation. Studies of both Tourette syndrome and simple tic have found that approximately 30% of patients have a positive family history of tic. The significance of this figure depends on a number of factors, in particular the prevalence of positive tic histories in the population. If the latter figure is 10%, which the best available evidence suggests is a reasonable estimate, approximately 30% of families in the general population would be expected to contain at least one present or former tiquer. It is argued, therefore, that the family aggregation findings in Tourette syndrome do not support the hypothesis that the condition has a significant genetic component. Methodological considerations for future research are discussed.

Female↗
PubMed1978

An early behavioral description of a person with Turner's syndrome.

A person with Turner's syndrome was described by Dr. Charles Pears in the Philosophical Transactions of the Royal Society, London, in 1805. The description included behavioral traits of mild temperament, absence of heterosexual interests, and concern about social stigmatization. These traits are the object of current behavior genetic studies of persons with Turner's syndrome.

England↗
PubMed1977

Intellegence among persons with Turner's syndrome.

Wechsler intelligence scale IQ distributions from a representative sample of 67 persons with Turner's syndrome are compared with distributions from a control sample of subjects individually matched for age, race, education, and other social characteristics. Among the probands, there is no increased incidence of either severe or moderate retardation, intelligence is similar regardless of karyotype or somatic stigmata, and the characteristic cognitive deficit is similar among both children and young adults.

Adolescent↗
PubMedDate not supplied

Organic status, psychological disturbance, and pain report characteristics in low-back-pain patients on compensation.

The relationship betewwn compensation and three variables--psychologic disturbance, organic status, and pain report characteristics--was assessed. Patients on compensation were clinically similar to patients not on compensation in the relative frequency of cases of psychologic disturbance and nonorganic findings in each group. Patients on compensation differed only when objective evidence of organic disease and psychologic stability was present. Under these circumstances, the compensation group used 43% more words to describe their pain and endorsed more pain qualities on five independent dimensions of pain. These results indicate that compensation primarily affects the description of low-back pain in cases where objective evidence of injury is present and leads to an intensification of sensory discomfort. Little justification was found for the atmosphere of suspicion that surrounds patients on compensation who have no evidence of organic disease.

Adult↗
PubMedDate not supplied

Epilepsy and verbosity.

Stories were elicited from 29 epileptic patients with generalized, simple partial, and complex partial seizures with bilateral, right, or left foci, and from 32 persons in two control groups. Four older epileptic patients with long histories of left complex partial seizures were verbose. Their stories involved trivial and subjective details, consistent with circumstantiality and suggesting the substrate for a hallucinatory syndrome.

Adolescent↗
PubMedDate not supplied

A comparison of patients treated by chymopapain and laminectomy for low back pain using a multidimensional pain scale.

Seventy-seven patients treated by chymopapain and laminectomy were compared before, and 6 and 14 weeks after, treatment. A standardized, multidimensional scale of low back pain providing scores on 7 independent dimensions of sensory and affective discomfort and one measure of intensity were used. Fourteen weeks after surgery, patients treated by chymopapain were functioning as well as those treated by laminectomy. Major differences, however, characterized the course of recovery. Chymopapain produced rapid change, which was maintained over the 3 1/2-month period. Healing following laminectomy was slower, but the end results were essentially the same. These findings, using sophisticated measurement techniques, support previous research suggesting that chymopapain is an effective alternative to laminectomy in the treatment of lumbar disk disease.

Adult↗