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Biomedical subjects

D C Garron

Publications and source records attributed to D C Garron.

At least 37 records · Page 2Linked to original sources
PubMed1982

Psychological depression and cancer.

Studies are reviewed which relate to five basic content areas of research concerning depression and cancer: significant loss experience, emotional inhibition, hopelessness, psychiatric assessment of depression, and test measurement of depression. Methodological issues within each area are addressed as they relate to the potential validity and generalizability of findings. In general, there is no support for increased loss experience in cancer patients and mild support for increased emotional inhibition and hopelessness in these individuals. Traditional psychiatric assessment approaches are not seen as providing solid evidence for a depression/cancer relationship due to reliability and design issues, while psychometric assessment provides mild support for a prospective relationship between depression and later cancer. Issues relating to approaches to research, means of measurement of depression, design issues, and questions of conceptualization of depression are discussed.

Affective Symptoms↗
PubMed1982

Rorschach and pain characteristics of patients with low back pain and "conversion V" MMPI profiles.

Two studies examined the relationship between Rorschach determinants, MMPI scale scores, and pain reports in order to clarify the meaning of the MPI "conversion V" pattern among patients with low back pain. Study I showed that patients without demonstrable organic disease of the back produce Rorschach response summaries marked by lower F+%, lower Sum C, and higher F% than patients with demonstrable organic disease. Study 2 showed that only the increase in F% was associated with significant elevations of the MMPI Hs and Hy scales. The results suggest that elevated MMPI "conversion V" profiles are indicative of psychological disturbance among patients with low back pain. It is unlikely, however, that the disturbance is hysterical. Instead, the psychopathology is probably marked by tension and constraint rather than the over-reactivity of hysteria. The implications of these findings for diagnosis are discussed.

Adolescent↗
PubMed1981

Psychological depression and 17-year risk of death from cancer.

Psychological depression, measured in 1957-1958 by the Minnesota Multiphasic Personality Inventory at the baseline examination of 2,020 middle-aged employed men, was associated (p less than 0.001) with a twofold increase in odds of death from cancer during 17 years of follow-up. The association did not vary appreciably in magnitude among the early (1958-1962), middle (1963-1968), and later (1969-1974) years of follow-up, persisted after adjustment for age, cigarette smoking, use of alcohol, family history of cancer, and occupational status, and was apparently not specific to any particular site or type of cancer. This result, predicted in advance on the basis of findings by other investigators, is consistent with the hypothesis that psychological depression is related to impairment of mechanisms for preventing the establishment and spread of malignant cells.

Adult↗
PubMed1980

Carotid artery disease, carotid endarterectomy, and behavior.

Thirty-five carotid endarterectomy patients and 17 peripheral vascular surgery controls were evaluated psychologically preoperatively and postoperatively. The endarterectomy sample was restricted to patients with transient ischemic attacks. Neuropsychological tests included measures of language, attention, memory, problem solving, and sensory and motor skills. Personality tests included measures of general psychopathology, with specific evaluation of anxiety and depression. Mean scores of the endarterectomy and control groups were not statistically significantly different preoperatively for any test. Postoperatively, only the endarterectomy group showed mean improvement on measures of memory and verbal fluency. Both groups showed improvement on several other neuropsychological measures, and in reduction in state anxiety and on another indicator of psychopathology. Endarterectomy patients whose cognition improved postoperatively were younger, better educated, and had lower admitting systolic blood pressure; they also tended to have a lesser incidence of generalized vascular disease.

Anxiety↗
PubMed1980

Validity of a back pain classification scale for detecting psychological disturbance as measured by the MMPI.

Constructed a Back Pain Classification Scale (BPCS) to detect serious psychological disturbance in low back pain patients, validated against the MMPI. One hundred and twenty patients with low back pain were classified as functional or organic on the basis of BPCS scores. The group identified as psychologically disturbed (functional) had significantly higher MMPI elevations on Scales F, HS, D, HY, PD, MF, PA, PT and SC. None of their scale scores was significantly lower than the group identified as organic. T-scores above 70 were present only on Scales 1 and 3, which suggests a high incidence of essentially neurotic disorders in patients classified as functional. The use of the BPCS as a viable alternative to the MMPI in the medical setting was discussed.

Adult↗
PubMed1980

High speed memory scanning in parkinsonism.

This study tested the hypothesis that the slowing seen in parkinsonism includes cognitive as well as motoric components. The sample consisted of 20 nondemented parkinsonian patients, group matched to 16 normals by age, education, and verbal IQ. Each group was divided into young (64 and under) and old (65 and over) subsets. The Sternberg character classification paradigm was used to measure the speed and accuracy of one cognitive function, short term memory scanning. Following a logarithmic transformation of the reaction time data, scanning speed was found to be increased, but only for the elderly patients (p = .01). Scanning accuracy was normal for both patient groups. These findings suggest that at least one cognitive function, the scanning of elements held in short term memory, is slowed in parkinsonism. This mnemonic slowing, like bradykinesia, is seen primarily in elderly parkinsonian patients. It is not readily explained as a motor phenomenon, as part of a generalized mnemonic or intellectual deficit, or as an artifact secondary to periodic extreme reaction times. The term bradyphrenia, used in early descriptions of parkinsonism, may be an apt descriptor of this deficit.

Age Factors↗
PubMed1980

Psychological features of Huntington's disease and the problem of early detection.

Huntington's disease (HD) is a chronic degenerative neurologic disorder inherited as an autosomal dominant trait. Symptom onset typically occurs at about age 40, and considerable effort has been expended in attempts to diagnose the disorder prior to the childbearing years. We review attempts to use psychological tests in early diagnosis. Specifically, we identify variables that show promise as early markers of the disorder, review evidence that a prodromal phase may exist, analyze the few prospective studies of persons at risk for HD, and consider the logical and methodological problems involved in early detection research.

Humans↗
PubMed1979

Differential effects of age and cerebral atrophy upon span of immediate recall and paired-associate learning in older patients suspected of dementia.

Seventy-eight patients suspected of dementia, 50 years of age or older and without evidence of focal cerebral lesion or systemic illness, were administered the Digit-Span Forward and Paired-Associate Learning subtests of the Wechsler Memory Scale. Computerized axial tomography, allowing a visualization and measurement of the lateral ventricles and cortical sulci, was employed to measure cerebral atrophy. Four groups were defined as follows: (1) age 50-69, without atrophy (N = 27), (2) age 50-69, with atrophy (N = 17), (3) age 70-89, without atrophy (N = 18), (4) age 70-89, with atrophy (N = 16). Results of analyses of variance indicate that Digit-Span is affected by cerebral atrophy but not by age, while Paired-Associate Learning is affected by both age and cerebral atrophy. No interaction effect between age and cerebral atrophy was found for either task. These results are discussed within the context of previous research, and implications for both models of memory and theories of the effects of cerebral atrophy in different ag groups are suggested.

Age Factors↗
PubMed1979

Demographic and affective covariates of pain.

Relationships of four demographic variables and five affective variables to eight attributes of low back pain were investigated in 251 patients by stepwise, multivariate analysis. The demographic variables are age, sex, race, and education. The affective variables are state anxiety, trait anxiety anxiety, hostility, and depression. Seven of the pain variables are from the factorially derived Low Back Pain Questionnaire. The eighth pain variable is a self-estimate of intensity. Relationships among demographic and pain variables are small and unsystematic. Hostility has a small, systematically inverse relation to pain variables, supporting theories relating low back pain to inhibition of anger. Anxiety has a small positive relationship, and depression has no relationship to pain variables. In general, the small relationships indicate that the Low Back Pain Questionnaire provides descriptions of pain that are not confounded by social characteristics or current emotional states of patients.

Adult↗
PubMed1979

Effect of aging on brain respiration and carbohydrate metabolism of CBF1 mice.

Brain slices of mice (strain CBF1) were used to study the effect of aging on cerebral cortex respiration and metabolism. Young animals (average age 6 months) were compared with old animals (average age 34 months). Metabolism was measured at a normal temperature (37 degrees C) and under hyperthermic stress (40 degrees C). The brain slices were incubated with 14C-glucose under standard conditions with the following parameters being measured: oxygen uptake, 14CO2 production, glucose utilization, and lactate and pyruvate formation. At the normal temperature, there were significant age-associated decreases in oxygen uptake and 14CO2 production but the other parameters were unchanged. At hyperthermic conditions there were significant age-associated decreases in oxygen uptake, 14CO2 production, lactate production, and glucose utilization. Also, in the hyperthermia study, all values were raised from control study values (37 degrees C) with old animals showing smaller increases in glucose utilization and lactate formation. These findings indicate the dysfunction of a number of metabolic pathways in the aged animal.

Aging↗
PubMed1979

Factor structure of Rabin's Child Study Inventory.

Factor analysis of responses by 213 persons to Rabin's Child Study Inventory result in five reliable factors. These five, termed Parental Fatalism, Parental Nurturance, Children's Independence, Parental Instrumentalism, and Children's Happiness, are similar to Rabin's original four parental motives of Altruism, Fatalism, Narcissism, and Instrumentalism. Two basic dimensions by which the five factors may be characterized are (a) whether the parent or child is the object, and (b) whether the feeling is personal or impersonal.

Journal Article↗
PubMed1979

Cerebral atrophy, EEG slowing age, education, and cognitive functioning in suspected dementia.

Seventy-eight hospital patients, 50 years of age or older, were selected for suspected changes in mentation and for the absence of focal or other organic brain disease. They were studied in relation to education, age, cerebral atrophy (by computerized tomography), electroencephalographic (EEG) slowing, and performance in several neuropsychologic tests. Adequate test-retest reliability of the cognitive measures and interjudge reliability of the cerebral atrophy and EEG measures were demonstrated. Stepwise multiple regression analyses suggested the following: (1) EEG slowing is the strongest and most general pathologic influence on cognition in elderly persons without overt brain disease. (2) Cerebral atrophy independently affects primarily the verbal recall of recent and remote information. (3) Age independently affects primarily recent memory for both verbal and nonverbal material. (4) Formal education is a powerful influence that must be accounted for in all studies of the effects of age on cognition.

Age Factors↗
PubMed1978

Predictors of mortality in presenile and senile dementia.

Forty-seven hospitalized patients with a diagnosis of presenile or senile dementia and without focal neurological disease of major systemic illness were given complete neurological, neuroradiological, and neuropsychological examinations. Mortality at one year after hospitalization was determined, 12 patients being lost to follow-up. Of the remaining 35 patients, 19 were alive and 1l had died. These groups did not differ in age, education, length of dementia history, sex, race, or degree of cerebral atrophy (by computerized tomography). Significant differences were found in degree of electroencephalographic abnormality and in 8 of 14 cognitive measures, the the largest single difference being on a test of expressive language. Discriminant function analysis made with the cognitive measures as dependent variables yielded a correct prediction (classification analysis) of mortality in all but 1 case (97% accuracy). These results suggest that (1) degree of functional brain impairment rather than degree of cerebral atrophy may be the more important influence on mortality in dementia patients without focal lesions, (2) short-term survival may be accurately predicted in such patients by tests of cognitive functioning, and (3) expressive language deficit in such patients may indicate a particularly poor prognosis for survival.

Aged↗