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Biomedical subjects

D Bergqvist

Publications and source records attributed to D Bergqvist.

At least 649 records · Page 36Linked to original sources
PubMed1976

Roll seat belt induced injury of the duodenum.

A case of duodenal rupture with a roll three-point seatbelt is described. It is apparently the seventh reported case of duodenal rupture in safety belt users. A female driver fell asleep, and her car went off the road, rolling forward in a ditch, slowing slightly, and then came to a sudden stop. The rupture was unusual: on the first part of duodenum, intraperitoneal, and longitudinal. The rupture mechanism is discussed, and the deficiencies of the roll seatbelt pointed out in accidents like the one described.

Adult↗
PubMed1976

Haemostasis in the microvasculature of the rabbit mesentery, effects of some pharmacological agents of current interest in haemostasis and thrombosis.

A study has been performed to evaluate the effect on haemostatic plug formation in the rabbit mesenteric microcirculation of some principally different pharmacological substances of current interest in thrombosis research. It seems as if agents which have a potential value in the prophylaxis of venous thrombosis also modify haemostasis in our experimental model.

Animals↗
PubMed1976

Thrombosis following hip arthroplasty. A study using phlebography and 125I-fibrinogen test.

Venous thrombosis after hip arthroplasty was studied using the 125I-fibrinogen test and phlebography. Eight out of ten dextran-treated and six out of ten control patients developed thrombosis. The thrombi were small and most frequently dorsal and dorso-lateral veins were involved. There were no thigh thrombi without concurrent calf thrombi. Half of the thrombi were found within the first postoperative week whereas the remainder occurred later. Preoperative venous pathology predisposed to postoperative thrombosis.

Aged↗
PubMed1976

The haemodynamic and antithrombotic effects of intermittent pneumatic calf compression of femoral vein blood flow. A comparison between different pump types.

The haemodynamic effects of intermittent pneumatic calf compression on femoral vein blood flow in dogs and patients were studied by measurement with an electromagnetic flow meter. Two pump types were compared at different inflation pressures, one with a continuous inflation-deflation cycle of 2 min and the other causing inflation over 3 sec and deflation over 20 sec, with a frequency of three per minute. A fast rate of splint inflation created a greater haemodynamic change in net volume flow, peak flow and flow amplitude with an optimal pressure of 40 mmHg. The slower pump in fact decreased mean volume flow. Using an experimental thrombosis model both pump types significantly prolonged the occlusion time of implanted steel tubes, but did not differ from each other.

Animals↗
PubMed1975

Haemostatic plug formation and stability in the rabbit mesentery after femoral fracture.

The effect of standardised trauma (femoral fracture) on the formation time and stability of haemostatic plugs in transected microvessels of the rabbit mesentery was studied in relation to alterations in fibrinogen concentration, platelet count, platelet adhesiveness, and haematocrit. In contrast to most other studies, platelet adhesiveness as a percentage was found to decrease post-traumatically. One week after trauma, the haemostatic plugs were maximally stable and at the same time venular haemostatic plug formation time was significantly reduced. These findings coincide with high levels of fibrinogen and increased numbers of circulating adhesive platelets.

Animals↗
PubMed1975

Measurements of blood flow velocity in the microcirculation.

A method for the measurement of red blood cell velocity in the microcirculation is described. The technique is based on the on-line cross-correlation of the delay between optical signatures derived from photodetectors aligned in direction oflow. A specialised photodiode holder which can be inserted directly in place of an ocular is described. The interdetector delay data is computed automatically from the cross-correlation function by a peak detector designed to provide a voltage proportional to the delay to maximum cross-correlation, regardless of intermediate lower peaks. Application of this system to measurements in the rabbit ear chamber, mesentery and skeletal muscle is described.

Blood Flow Velocity↗
PubMed1975

The incidence of venous thrombosis in the lower limbs following elective gallbladder surgery.

The frequency of postoperative venous thrombosis and the prophylactic effect of dextran 40 and 70 were studied in 90 otherwise healthy patients undergoing cholecystectomy. The 125-I-fibrinogen test was employed as the diagnostic method. The frequency of thrombosis was very low (1.1%) compared with other investigations on patients undergoing elective general surgery. Thus nothing can be concluded about the prophylactic effect of dextran from this series, but it can be presumed that this type of patient does not need routine prophylaxis against deep venous thrombosis.

Adult↗
PubMed1975

The effect of platelet function inhibitors on experimental venous thrombosis formation in rabbits.

Inhibitors of the platelet functions, collagen-induced aggregation and release reaction (ASA and sulfinpyrazone) and ADP-induced aggregation (dipyridamole and VK 744), were investigated as potential preventive agents against venous thrombosis formation in rabbits. An experimental model combining endothelial damage (sodium morrhuate) and controlled stasis of the femoral venous flow was used. None of the agents showed any significant protective effect against venous thrombosis, a finding which is in keeping with the results of recent clinical investigation.

Adenosine Diphosphate↗
PubMed1975

Platelet reactivity ex vivo and in vivo after acute and chronic treatment with sodium caprylate.

The effect of sodium caprylate on platelet function and other hematological parameters was studied, using rabbits as experimental animals. Intravenous administration of caprylate resulted in a pronounced, although transient, inhibition of platelet reactivity as measured by the laser technique. A single oral dose of caprylate had no effect on platelet adhesiveness. Long-term oral administration of caprylate (2 and 3 weeks) to rabbits resulted in a progressive and significant decrease in platelet adhesiveness in these animals compared to that in a control group receiving saline. However, the platelet reactivity to laser damage was not changed after administration of caprylate for 3 weeks. Other hematological parameters such as hematocrit, plasma cholesterol, triglycerides, and ketone body concentrations were not altered by the treatment.

Acetoacetates↗