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Biomedical subjects

D Bach

Publications and source records attributed to D Bach.

At least 127 records · Page 7Linked to original sources
PubMed1988

Interaction of furosemide with lipid membranes.

The interaction of furosemide with different phospholipids was investigated. Its influence on the lipid structure was inferred from its effect on the phase transition properties of lipids and on the conductance of planar bilayer membranes. The thermotropic properties of dipalmitoyl phosphatidylcholine, phosphatidylethanolamine (natural), dipalmitoyl phosphatidylethanolamine, brain sphingomyelin, brain cerebrosides and phosphatidylserine in the presence and absence of furosemide were investigated by differential scanning calorimetry. The modifying effect of furosemide seems to be strongest on phosphatidylethanolamine (natural) and sphingomyelin bilayers. The propensity of furosemide to decrease the electrical resistance of planar lipid membranes was also studied and it is shown that the drug facilitates the transport of ions. Partition coefficients of furosemide between lipid bilayers and water were measured.

Cerebrosides↗
PubMed1988

Scintigraphy for the diagnosis of testicular torsion and differential diagnosis of acute intrascrotal processes.

Twenty-five patients suffering from acute painful testicular processes were subjected to scintigraphy. Testicular torsion in the early and delayed phases were diagnosed with 100% accuracy, but one out of 7 cases of epididymitis was wrongly recognized as negative. Interoperative diagnosis in two cases of hydatid torsion proved the foregoing scintigraphic finding to have been wrong. Nevertheless, scintigraphy was found to be reliable in testicular torsion diagnosis.

Acute Disease↗
PubMed1988

Ultrasound guided percutaneous biopsy or operative biopsy in patients with renal impairment?

Sixty-four percutaneous renal biopsies under ultrasound guidance done in 60 patients with renal impairment are compared with 33 open, operative biopsies. In 62 percutaneous biopsies (96.8%), more than 3 glomeruli could be obtained. Eight biopsies (12.5%) presented with minor complications afterwards. All of them were spontaneously reversible. In the operative biopsy group, there were complications in 6 patients (18.2%). In 2 cases, operative revision was necessary. In conclusion, percutaneous ultrasound guided biopsy in experienced hands offers several advantages in patients with renal impairment. It must be kept in mind that from a minority of patients only an operative biopsy can be taken due to certain risks.

Adult↗
PubMed1988

Colonic complications in renal transplant recipients.

Complications involving the colon occurred in 28 of 325 patients who received renal transplants. Pseudomembranous colitis, the most common complication, affected 15 patients, two of whom required surgery. Three instances of diverticulitis were complicated by free perforation in two cases, and by colovesical fistula in one. Appendicitis occurred in two cases. The other complications were hemorrhage (from diverticulosis or angiodysplasia), nonspecific colitis, and ischemic colitis. Spontaneous colonic perforation did not occur. Two thirds of the colonic complications occurred within 30 days after transplantation. All cases of colon perforation, however, occurred later than one month after transplantation. It is concluded that pseudomembranous colitis is the most common colonic complication in renal transplant recipients, that it usually occurs early, and that it carries a good prognosis. Colonic perforations occurred later in this series and were treated successfully. All cases of ischemic colitis were part of terminal multiorgan system failure.

Appendicitis↗
PubMed1988

Late results after sclerotherapy of varicocele.

Percutaneous sclerotherapy is technically feasible in about 80% of patients with idiopathic varicocele. Persistence must be reckoned with in 3-5% of the cases. Sclerotherapy is a low-risk technique which can be applied on an outpatient basis in the vast majority of cases. In about 40% of the cases, an improvement of the fertility can be attained by raising the spermatozoal density; the total motility and morphology of the spermatozoa can only be slightly improved by this therapy. Percutaneous sclerotherapy is to be recommended as an alternative to surgery since it provides equally good results, is cheaper and causes hardly any complications.

Adult↗
PubMed1988

The UGI series in renal transplant candidates.

We reviewed the charts of 115 renal transplant recipients who had pre-transplant upper gastrointestinal (UGI) barium examinations to assess this examination as a predictor of post-transplant ulceration and hemorrhage. In the past surgical therapy for peptic ulcers was recommended before transplantation because of the risk of life-threatening hemorrhage after transplantation. Peptic ulcer disease was found in 22 patients. Fifteen of these were treated with histamine H2-receptor antagonists and none had ulceration post-transplantation. Three of the seven not so treated had recurrent peptic ulceration. The other 93 examinations were normal. Twelve of the patients with normal examinations developed post-transplant peptic ulceration. We conclude that: (a) the pre-transplant UGI series may not distinguish those patients at risk of UGI ulceration post-transplantation and (b) treatment with H2-receptor antagonists obviates the need for surgical therapy of peptic ulcer disease in these patients before transplantation.

Barium Sulfate↗
PubMed1987

X-ray diffraction study of cholesterol-phosphatidylserine mixtures.

Phosphatidylserine-cholesterol mixtures at a molar ratio of 2:1 were investigated by X-ray diffraction. Phase separation of cholesterol independent of temperature was detected, indicating limited solubility of cholesterol in phosphatidylserine bilayers. The second phase present, the mixed phospholipid-cholesterol phase, continued to undergo melting as determined by changes with temperature in both the small angle scattering profile and in the acyl chain packing.

Cholesterol↗
PubMed1987

[Ultrasonic-guided percutaneous renal biopsy in patients with renal insufficiency].

64 percutaneous renal biopsies were done on 60 patients with renal impairment (serum creatinine level more than 1.5 mg%) under sonographic guidance. In 62 biopsies (96.8%), more than 3 glomeruli were seen, in 45 biopsies (70.3%) the amount of at least 10 glomeruli could be obtained, this being the amount desirable for a good histological diagnosis; 8 cases (12.5%) presented with minor complications after the biopsies. All of them resolved spontaneously. Ultrasound-guided percutaneous renal biopsy is a safe procedure for rapid diagnosis and induction of a specific therapy in patients with renal impairment.

Adolescent↗
PubMed1986

Effect of ethylene glycol on the phase transition kinetics of gluco- and galactocerebrosides.

The effect of different concentrations of ethylene glycol in water on the phase transition (metastable----stable state) of Gaucher's glucocerebroside, of bovine brain cerebroside type II (non hydroxy acyl chains only) and of N-palmitoylgalactocerebroside has been investigated. The phase transition and its kinetics were inferred from the thermograms at different heating and cooling rates and confirmed by FTIR spectra of the cerebrosides in the different states. The significance of the conformational differences of the glucose and of the galactose residues with respect to their solvation, and the subsequent effect on the intermolecular interactions and the phase transition is discussed.

Calorimetry, Differential Scanning↗
PubMed1986

Barium gun for use in enteroclysis.

A simple modification of a caulking gun for the administration of high-viscosity barium during small-bowel enteroclysis is described.

Barium Sulfate↗
PubMed1986

The effect of verapamil on antipyrine pharmacokinetics and metabolism in man.

The effect of verapamil pre-treatment on the pharmacokinetics and metabolism of antipyrine was studied in eight healthy male volunteers. The oral clearance of antipyrine was decreased from 2.18 to 1.95 l h-1 (P less than 0.01) by verapamil (80 mg three times daily for 2 days prior to antipyrine administration and 2 days following) while half-life was increased from 13.2 to 15.6 h (P less than 0.01). The urinary excretion of norantipyrine, 4-hydroxyantipyrine and 3-hydroxymethylantipyrine was decreased by 19.2%, 23.1% and 16.7% respectively (P less than 0.05) in the presence of verapamil. In addition, the rate constants for formation of each of these metabolites were significantly decreased by an average of approximately 30%. These results suggest that verapamil is capable of inhibiting oxidative metabolism, a finding which could be of clinical significance for drugs highly dependent upon pathways such as those inhibited in this study for elimination.

Adult↗