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Biomedical subjects

D B Stough

Publications and source records attributed to D B Stough.

At least 37 records · Page 2Linked to original sources

Modification of a trypsin-detergent method for DNA flow cytometry of human epidermis.

An existing technique (Vindelov et al. Cytometry 3:323, 1983) has been modified for DNA flow cytometry of human epidermis obtained from 2 to 3 mm punch biopsies. By varying the length of time of digestion of the epidermal disc by trypsin from 5 to 70 min a controlled release of keratinocytes occurred beginning with the stratum basale and proceeding toward, but not including, the superficial layer of the epidermis, the stratum corneum.

Cell Communication↗

A spitting image.

Three cases of injection of human saliva are presented, all of which occurred among incarcerated men. Although no previous cases have been described, we believe that this entity is not uncommon in the prison population.

Adolescent↗

Giant angiofibroma without accompanying tuberous sclerosis.

Angiofibromas occur in a variety of settings but can be markers for underlying tuberous sclerosis. We report an unusual giant angiofibroma occurring in a patient without associated disease. The suggested work-up for patients with tuberous sclerosis is also reviewed.

Biopsy↗

A contemporary approach to male pattern alopecia.

Male pattern alopecia can be significantly improved with punch autografts, scalp reductions, and/or hair-bearing flaps. In the authors' experience, the choice of the appropriate surgical modality is expedited by utilizing the classification of baldness coupled with the quality of the donor hair.

Adult↗

Genodermatoses with malignant potential.

Cowden's disease, which is characterized by multiple facial papules, gingival papillomas, acral papules, and other hamartomatous lesions, represents a genodermatosis with a high incidence of breast and thyroid carcinoma.

Adult↗

Surgical procedures for the treatment of baldness.

New surgical methods are now available for the correction of male pattern baldness. Standard techniques have been significantly refined during the past decade. These methods include punch autografts, strip grafting, scalp reduction, use of hair-bearing flaps, microsurgery, and various combinations of these techniques. A more recent refinement of hair transplantation is the use of minigrafts and micrografts. We present an overview of the advantages and indications for each procedure.

Adult↗

Refining the hair-bearing flap.

The availability of hair-bearing flaps offers patients a more extensive choice of corrective procedures for baldness. The hair-bearing axial temporoparietal-occipital (TPO) flap which we prefer is based on the superficial temporal artery and extends well past the posterior midline. The procedure is performed in the office. The "instant" and exceptionally dense hair which grows in patients with sparse, limited, and finely textured hair is a distinct advantage over the hair transplanted by punch autograft technique. Since the surgery involved is formidable, the patient must be highly motivated, well-informed and advised realistically about the results available with this procedure. A well-planned and properly executed TPO flap procedure is the best method for obtaining the density of hair and the appearance desired within the shortest time.

Adolescent↗

Updating reduction and flap procedures for baldness.

Corrective surgery for baldness now includes scalp reduction, hair-bearing flaps, and punch autografts. When baldness is mild to extreme in the vertex or anterior vertex, scalp reduction is usually indicated. By reducing the bald area of patient with extreme alopecia, a dense back-ground of hair is provided for implants in both the anterior vertex and frontal regions. Hair-bearing flaps are recommended for those with a marginal outline pattern of excessive baldness and for those with very fine, sparse hair who wish to attain strong and dense frontal growth. Using these advancements results in immediate or "instant" hair. All available adjuncts should be considered for adequate coverage and a natural appearance in the extremely bald patient.

Alopecia↗

Contemporary techniques of hair replacement.

For the bald patient who is not satisfied with a hairpiece, various surgical techniques of hair replacement provide good results with minimal side effects. The punch autograft technique, in which hair is taken from the lateral portions of the scalp, is most widely used. If this technique is not adequate in a case of extensive baldness, it can be augmented by surgical resection of tissue from the bald site or by fashioning of flaps from hair-bearing areas. In all of these techniques, design of the frontal area to provide a natural appearance is of primary importance.

Alopecia↗

Innovative adjuncts in hair transplantation.

After development of the technical, organizational, and esthetic phases, hair transplantation has progressed to a fourth stage. This is a comprehensive approach determined by the patient's degree of baldness and may require a combination of procedures to best correct the patient's defect. The punch autograft technique remains fundamental for most patients at this time, while scalp reduction, flaps, and various types of grafts may be selective adjuncts. "Individualization" is being achieved through these various ancillary modalities.

Adult↗

The esthetics of hair transplantation.

There are many potential candidates, and greater attention to esthetic considerations has accelerated the interest in the hair transplantation field. Although discriminatory selection is essential, there are few interested patients who could not benefit from this procedure. Successful hair transplantation and patient satisfaction depend on the physician's skillful sustained concentration on the frontal hairline, tenacious motivation of the patient to seek a sufficient number of transplants, and the choice of a pleasing hair style with utilization of recommended grooming aids.

Alopecia↗