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Biomedical subjects

D B Stough

Publications and source records attributed to D B Stough.

At least 19 recordsLinked to original sources

The paramedian scalp reduction with posterior Z-plasty. A technique to minimize the "slot" defect.

BACKGROUND: One consistent and undesired sequela resulting from scalp reductions has been the "slot" or "trough" defect, referring to the scar following the final reduction. Attempts to correct this have not been entirely satisfactory. OBJECTIVE: To present an approach to minimize the "slot" defect that consists of staged modified paramedian scalp reductions combined with a large posterior Z-plasty during the final reduction. METHODS: A paramedian crescent-shaped ellipse was marked onto the patient's scalp parallel and adjacent to the existing fringe hair. Subsequent reductions were performed in a similar manner approximately 2 months apart. The final reduction consisted of mobilization and transposition of the large flaps used in the posterior Z-plasty. RESULTS: Patients who underwent the staged modified paramedian reductions combined with a posterior Z-plasty had significant minimization and adequate camouflage of the undesirable "slot." CONCLUSION: Combining a large posterior Z-plasty with a paramedian reduction minimizes the slot defect.

Alopecia

Extended survival of patients with primary systemic amyloidosis.

Systemic amyloidosis can produce a wide variety of clinical manifestations, including characteristic cutaneous findings. Large series of patients with primary systemic amyloidosis have shown that systemic amyloidosis, with or without associated myeloma, has a median survival of no more than twenty-four months. We present a case of systemic amyloidosis that has been present in a woman for eighteen years, as manifested by periorbital purpura and an immunoglobulin G kappa light chain paraproteinemia. She was otherwise healthy; results of bone marrow examination showed no overt myeloma. We speculate that kappa light chain paraproteinemia could prove to be a marker for a more benign type of systemic amyloidosis.

Aged

Treatment of keratoacanthomas with intralesional methotrexate.

Multiple modalities exist for the treatment of keratoacanthoma. Excisional surgery is currently the treatment of choice for the majority of keratoacanthomas. This can result in functional and cosmetic defects when large or strategically located lesions are treated. An effective nonsurgical treatment would be desirable in such cases. Intralesional therapy, particularly with 5-fluorouracil, has been shown to be effective in the treatment of keratoacanthomas. Systemic methotrexate has been tried, with variable success. We report an open, noncontrolled study of nine consecutive patients with unusually large or strategically located solitary keratoacanthomas treated successfully with intralesional methotrexate. All lesions responded promptly, with complete resolution after a mean of 3.0 weeks and a mean of 1.7 injections. No side effects occurred, and scarring was minimal. We concluded that intralesional methotrexate is a simple and effective modality for the treatment of select keratoacanthomas and may offer greater efficacy, a more rapid response, decreased pain, and lower cost compared with intralesional 5-fluorouracil.

Adult

Incisional slit grafting.

Incisional slit grafting, a new and greatly improved technique in hair transplantation, is described. Incisional slit grafting utilizes larger numbers of smaller grafts than does traditional punch grafting. No tissue is removed from the recipient bed. The vascular supply is conserved, resulting in an increased graft yield. The clumping and stalking effect associated with traditional round grafting is eliminated largely, and a more natural frontal hairline is achieved.

Alopecia

Triple rhomboid flap for crown alopecia correction.

The triple rhomboid flap offers significant advantages over previously described methods for reducing vertex alopecia. The circular area of alopecia is converted into a hexagon. The hexagon is then excised and closed by rotation of three rhomboid flaps from the hair-bearing periphery. The specific indications for this flap are reviewed, the technical aspects are discussed, and illustrations are provided.

Alopecia

Modification of a trypsin-detergent method for DNA flow cytometry of human epidermis.

An existing technique (Vindelov et al. Cytometry 3:323, 1983) has been modified for DNA flow cytometry of human epidermis obtained from 2 to 3 mm punch biopsies. By varying the length of time of digestion of the epidermal disc by trypsin from 5 to 70 min a controlled release of keratinocytes occurred beginning with the stratum basale and proceeding toward, but not including, the superficial layer of the epidermis, the stratum corneum.

Cell Communication

A spitting image.

Three cases of injection of human saliva are presented, all of which occurred among incarcerated men. Although no previous cases have been described, we believe that this entity is not uncommon in the prison population.

Adolescent

Giant angiofibroma without accompanying tuberous sclerosis.

Angiofibromas occur in a variety of settings but can be markers for underlying tuberous sclerosis. We report an unusual giant angiofibroma occurring in a patient without associated disease. The suggested work-up for patients with tuberous sclerosis is also reviewed.

Biopsy

A contemporary approach to male pattern alopecia.

Male pattern alopecia can be significantly improved with punch autografts, scalp reductions, and/or hair-bearing flaps. In the authors' experience, the choice of the appropriate surgical modality is expedited by utilizing the classification of baldness coupled with the quality of the donor hair.

Adult

Genodermatoses with malignant potential.

Cowden's disease, which is characterized by multiple facial papules, gingival papillomas, acral papules, and other hamartomatous lesions, represents a genodermatosis with a high incidence of breast and thyroid carcinoma.

Adult

Surgical procedures for the treatment of baldness.

New surgical methods are now available for the correction of male pattern baldness. Standard techniques have been significantly refined during the past decade. These methods include punch autografts, strip grafting, scalp reduction, use of hair-bearing flaps, microsurgery, and various combinations of these techniques. A more recent refinement of hair transplantation is the use of minigrafts and micrografts. We present an overview of the advantages and indications for each procedure.

Adult

Innovative adjuncts in hair transplantation.

After development of the technical, organizational, and esthetic phases, hair transplantation has progressed to a fourth stage. This is a comprehensive approach determined by the patient's degree of baldness and may require a combination of procedures to best correct the patient's defect. The punch autograft technique remains fundamental for most patients at this time, while scalp reduction, flaps, and various types of grafts may be selective adjuncts. "Individualization" is being achieved through these various ancillary modalities.

Adult

The esthetics of hair transplantation.

There are many potential candidates, and greater attention to esthetic considerations has accelerated the interest in the hair transplantation field. Although discriminatory selection is essential, there are few interested patients who could not benefit from this procedure. Successful hair transplantation and patient satisfaction depend on the physician's skillful sustained concentration on the frontal hairline, tenacious motivation of the patient to seek a sufficient number of transplants, and the choice of a pleasing hair style with utilization of recommended grooming aids.

Alopecia