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Biomedical subjects

D Anthony

Publications and source records attributed to D Anthony.

At least 37 records · Page 2Linked to original sources
PubMed1996

The treatment of decubitus ulcers: a century of misinformation in the textbooks.

Decubitus ulcers are slow healing; in many cases they stagnate and fail to heal. Examination of the literature concerning decubitus ulcers reveals that there is a large body of treatments which have been suggested to stimulate the healing wound. This study examines the clinical effectiveness of the various treatments, and the scientific basis behind them. The treatments currently available are compared with those discussed in the literature over the last century, and common threads emerge which have a bearing on how literally one should accept the advice offered in current textbooks.

Anti-Infective Agents↗
PubMed1996

Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990.

PURPOSE: To describe the career characteristics of the graduates of the Medical Scientist Training Program (MSTP) at Duke University School of Medicine. METHOD: Surveys and information at administrative offices were used to collect data on all the 1970-1990 MSTP graduates in the summer of 1995. Of the 147 graduates, all but three had completed postgraduate training. In addition, data were available for 35 recent graduates (1991-1995), most of whom were in transition from training and fellowship positions to career positions. RESULTS: Of the 144 graduates from 1970 through 1990, 84 (58%) had selected careers in internal medicine or pathology. A total of 106 (74%) were involved in careers in academic medicine or research. Of these, 87 (82%) held full-time faculty appointments and devoted major efforts to basic or clinical research. Of this group, 59 (68%) were primary investigators receiving grant support from the National Institutes of Health (NIH). Of the 12 women graduates, 11 had careers in academic medicine or research, and seven were primary investigators on NIH grants. At the present time, 11 of 43 (26%) of the matriculating MSTP students are women. Five of the seven underrepresented-minority students in the MSTP have entered in the last five years. CONCLUSION: This study reinforces and extends previous conclusions concerning the success of federally funded MSTPs in producing physician scientists who compete favorably for NIH funding.

Academic Medical Centers↗
PubMed1996

A review of statistical methods in the Journal of Advanced Nursing.

Research-based articles in the nursing press have increased in number substantially, as indeed they have in other disciplines. While qualitative methods are more frequently use in nursing than some other areas (for example, medicine), the use of quantitative methods is common. It is noted that statistical errors and misunderstanding of statistical concepts are to be found in nursing journals. This paper analyses an academic nursing journal and comparisons are made with similar studies in medical journals.

Bias↗
PubMed1996

[Immunotherapy of tumors expressing IGF-I].

Recently we demonstrated that rat glioma cells when transfected with a vector encoding antisense IGF-I c-DNA lost tumorigenicity and induced a tumor specific immune response involving CD8+ lymphocytes. Here we showed, using immunostaining flow cytometry analysis, that the transfected cell lines, rat C-6 glioma and rat LF hepatoma, expressed an increase level of MHC-class I, and even the amount of MHC-I was found to be higher in the transfected hepatoma, than in the transfected glioma cells. This increased expression of MHC-I could contribute to the final immune recognition of tumour immunogenicity.

Animals↗
PubMed1995

Objective and subjective evaluations of Kodak Ektaspeed Plus dental x-ray film.

A new dental x-ray film, Kodak Ektaspeed Plus (Eastman Kodak Co., Rochester, N.Y.), was compared with Kodak Ektaspeed and Ultraspeed films. The comparison was based on objective measures (film contrast, speed, and fog levels) and subjective appraisals (film graininess and appearance). Ektaspeed Plus had higher contrast than Ektaspeed and in general similar contrast to Ultraspeed. Ektaspeed Plus was faster than Ektaspeed. Films were stored in various locations and base + fog determinations were made during a 16-week period. Ektaspeed Plus and Ultraspeed films were generally stable within this period. There were no meaningful differences in fog buildup based on storage location. Ektaspeed Plus had the least rate of buildup. Ektaspeed demonstrated the greatest rate of buildup and the greatest sensitivity to environmental factors. Periapical exposures were made of the molars of a manikin. These radiographs were subjectively assessed by three observers. The Ektaspeed Plus film was judged to appear less grainy than the Ektaspeed and to have a pleasing appearance. On the basis of the evaluations performed in this initial investigation, it was concluded that Ektaspeed Plus was superior to Ektaspeed film and was superior or equivalent to Ultraspeed film for dental radiography.

Absorptiometry, Photon↗
PubMed1995

A comparison of six intra-oral X-ray films.

OBJECTIVES: To compare objectively and subjectively national-brand dental X-ray films with widely available and less costly brands. METHODS: A range of dental films, including the recently released Kodak Ektaspeed Plus, was purchased from mail-order suppliers at the lowest published price. Objective measurements (film speed, contrast, fog levels, costs, physical characteristics) and subjective evaluations (ease of use, film graininess, overall appearance) were made. RESULTS: Private-label films were obtained at less cost than those of major vendors. Not all film speeds, sizes and wrapping materials were available from individual manufacturers. Objective measures and subjective appraisals showed that Ektaspeed Plus was the fastest film and had good contrast with the clinically useful density ranges. Agfa Dentus was the next fastest film, but it had rather low contrast and was grainier than the other films. The non-proprietary brands were difficult to open with primary glove barriers, making effective infection control practices arduous. All films were relatively stable over a 16-week period regardless of storage location. CONCLUSIONS: The major manufacturers offered more choices of film sizes and speeds than did private label suppliers. The films from the major manufacturers, although more expensive, were more conducive to effective infection control practices. Ektaspeed Plus had a performance comparable with or better than the other available films. Based on this preliminary study, it is recommended that this new film is considered as an alternative to D-speed films.

Absorptiometry, Photon↗
PubMed1995

The characterization of a rabbit model of inflammatory bowel disease.

The absence of a simple, clinically relevant, animal model of inflammatory bowel disease (IBD) hampers research into this disease. In this study, colitis was induced in rabbits by intracolonic installation of 2,4,6-trinitrobenzene sulphonic acid (TNB) in 25% ethanol. Rabbits were killed from zero hours to 6 weeks and their colons examined. Rabbits were examined by endoscopy at weekly intervals. A single dose of TNB in ethanol produced dose dependent inflammation and ulceration, which at its optimum (40 mg) resulted in cobblestoning, strictures, and bowel wall thickening. The damage score at endoscopy was consistent with the score on macroscopic examination of the colon. Histopathological features of inflammation and ulceration observed in all animals that received 40 mg TNB included crypt abscesses, ulceration, crypt architectural distortion and, occasionally, granulomas and pseudopolyps. These changes, which are similar to those observed in IBD, persisted for 6 weeks. No lasting abnormalities were observed in control animals treated with TNB in saline, with ethanol alone, or with saline only. Histopathological similarity and the prolonged duration of inflammation, compared to other models, make this a suitable model for investigating inflammation in the colon. Furthermore, the model is accessible to endoscopy which adds to its value in experimental studies.

Animals↗
PubMed1993

Effects of cocaine on hospital course in schizophrenia.

The authors selected at random every fourth inpatient chart (N = 79) of patients enrolled in a schizophrenia clinic for analysis of substance use patterns and psychiatric hospitalizations. Patients were divided into three groups based on operationally defined lifetime drug use histories: a) cocaine and other substance use; b) substance use without cocaine; and c) no substance use. All available hospital records were examined for presenting symptoms and psychosocial functioning at admission, neuroleptic dosing, and hospital management. Cocaine-using schizophrenics had significantly higher hospitalization rates than other substance-using or non-using patients. No differences were found in hospital presenting symptoms among any cohort. However, the cocaine-using schizophrenic patients demonstrated significantly higher rates of suicidal ideation after cocaine use compared with their own non-cocaine-associated hospitalizations or the other groups. The cocaine group also received higher neuroleptic doses by the fifth and sixth weeks of hospitalization compared with their own non-cocaine-associated hospitalizations and with the other groups. This suggests that cocaine use in schizophrenia is associated with poorer illness course and increased hospitalization, including higher rates of suicidal ideation and greater neuroleptic dose.

Adult↗
PubMed1992

Modulation of human neutrophil function by fibronectin degradation products isolated from cryoglobulins.

The proteolytic fragments of native fibronectin (cryopeptides) complexed to pathological immunoglobulins in cryoglobulins were isolated from the serum of six different patients. Two peptides of 117,000 daltons and 70,000 daltons were purified and characterized by N-terminal amino acid sequencing. The priming effect of the mixture of these two peptides, referred to as cryopeptides, on neutrophil functions, namely the respiratory burst, exocytosis, and Ca2+ release, was investigated. Cryopeptides and cryoglobulins assayed separately did not increase neutrophil respiration or cytosol free calcium concentration; however, both of them induced granule enzyme secretion. Sequential exposure of neutrophils to either cryopeptides or the respective cryoglobulins, and then to N-formyl-methionyl-leucyl-phenylalanine or serum opsonized zymosan, resulted in a synergistic stimulation of O2 uptake compared to the effect of N-formyl-peptides or opsonized zymosan tested separately; Ca2+ release was significantly enhanced by the pretreatment of neutrophils with cryopeptides. These data suggest that cryopeptides and cryoglobulins may play a role in host defense against bacterial infections through neutrophil activation.

Amino Acid Sequence↗
PubMed1989

Phase I study of an anti-breast cancer immunotoxin by continuous infusion: report of a targeted toxic effect not predicted by animal studies.

260F9 Monoclonal antibody-recombinant ricin A chain, an immunotoxin reactive with approximately 50% of breast carcinomas, was given by continuous iv infusion at a dose of 50 micrograms/kg per day or 100 micrograms/kg per day. Five patients with refractory breast cancer received treatment for from 6 to 8 days. Severe toxic effects, including marked fluid overload and debilitating sensorimotor neuropathies, occurred in most patients. Immunoperoxidase studies suggested that 260F9 monoclonal antibody targeting of the Schwann cells may have induced demyelination and subsequent neuropathy. This is the first report of a targeted toxic effect due to an immunoconjugate.

Adult↗
PubMed1987

A clinical study of Sudocrem in the management of dermatitis due to the physical stress of incontinence in a geriatric population.

A double blind controlled trial was carried out to measure the efficacy of Sudocrem, compared with zinc cream BP, in the treatment and prevention of incontinence-associated dermatitis in an elderly inpatient population. Three objective measures of skin condition were used to assess efficacy. Sudocrem was shown to be superior to zinc cream BP in the treatment of dermatitis, with no significant difference shown in terms of prophylaxis. The objective measures of skin health seemed to be a promising advance on earlier, subjective methods, and their further development is recommended. There was some indication that the normal skin of an incontinent patient does not deteriorate when managed with Sudocrem or zinc cream.

Aged↗
PubMedDate not supplied

CXC chemokines generate age-related increases in neutrophil-mediated brain inflammation and blood-brain barrier breakdown.

Children are at greater risk than adults of permanent brain damage and mortality following head injury or infection [1-5]. Rodent models have demonstrated a 'window of susceptibility' in young animals during which the brain parenchyma is at greater risk of acute neutrophil-mediated breakdown of the blood-brain barrier [6-7]. The exact mechanism of this age-related susceptibility to brain inflammation has yet to be defined, but animal models have revealed that the potent pro-inflammatory cytokine interleukin-1beta (IL-1beta) initiates an intense acute neutrophil-mediated inflammatory response in the brains of young rats and mice that is not seen in adults [6]. Here, we demonstrate the rapid induction of CXC chemokines (which contain a Cys-X-Cys motif), in particular the cytokine-induced neutrophil chemoattractant CINC-1, following the intracerebral administration of IL-1beta. The CXC chemokines produced a more intense neutrophil response in young rats than in adults. The IL-1beta-induced blood-brain barrier breakdown in young rats could be attenuated by an anti-CINC-1 neutralising antibody. These results show that the immature central nervous system (CNS) is dramatically more susceptible to the chemotactic effects of CXC chemokines. Blocking the CXC chemokine activity associated with brain inflammation inhibits neutrophil-mediated blood-brain barrier damage and represents a significant therapeutic possibility.

Adult↗
PubMedDate not supplied

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Computer Communication Networks↗