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Biomedical subjects

D Andreani

Publications and source records attributed to D Andreani.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Cell-mediated immunity and immune complexes in the pathogenesis of type 1 (insulin-dependent) diabetes.

Evidence for a role of the immune system in the pathogenesis of insulin-dependent (Type 1) diabetes is now plentiful. In the light of the lymphocytic infiltration in the islets of Langerhans, different autoaggressive mechanisms have been suggested in the initiation of B-cell damage. Lymphocytes characterized by cytotoxic properties (K cells) and having receptors for the Fc of IgG are increased in newly diagnosed Type 1 diabetics. Circulating immune complexes are also raised in these patients at the time of clinical diagnosis and there is evidence that K cells bind immune complexes which can modulate the activity of these cells. Here we propose a possible interrelationship between K or Fc gamma receptor+ T lymphocytes and immune complexes which could have a 'key' role in the mechanism of activation of cell-mediated immunity towards B-cells.

Antigen-Antibody Complex↗
PubMedDate not supplied

Inhibition of killer cell cytotoxicity induced by carbimazole in vitro.

The in vitro effect mediated by carbimazole (CBZ), a classical anti-thyroid agent on the antibody dependent cellular cytotoxicity (ADCC), low affinity E-rosetting cells (E-RFC) and high affinity E-RFC was investigated using lymphocytes from 11 normal subjects. CBZ at the doses of 250 and 500 mumol/l significantly reduced ADCC in all subjects studied. Low affinity E-RFC--mainly cells possessing receptors for the Fc portion of IgG and expressing cytotoxic properties in the ADCC system--were also significantly reduced following incubation with the same CBZ doses. These results suggest that CBZ, in addition to the known inhibitory effect on thyroid hormone synthesis, may be useful by depressing lymphocyte cytotoxicity in the treatment of autoimmune thyroid disease.

Antibody-Dependent Cell Cytotoxicity↗