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Biomedical subjects

D Anagnostopoulos

Publications and source records attributed to D Anagnostopoulos.

36 records · Page 2Linked to original sources

[Diagnosis of congenital tracheo-bronchial malformations in the newborn and infant].

Diagnosis endoscopy in congenital tracheo-bronchial abnormalities. High quality of anesthesia and efficiency of light sources and optical systems, now allow safe examination of upper respiratory tract and ability to give very precise informations in neonates and infants. Endoscopy now is then an essential procedure for diagnostic of congenital anomalies of respiratory tract. The necessary conditions for a safe examination and the necessity of complete exploration are exposed as well as endoscopic aspects of various congenital anomalies.

Bronchi↗

Gallbladder disease in patients with cystic fibrosis.

We retrospectively studied 18 patients with cystic fibrosis, who underwent surgery for gallbladder disease from 1975 to 1990. A long delay between the onset of symptoms and the diagnosis was noted (mean 8.7 months). This delay was attributed to masking of the symptoms of biliary disease by the malabsorption and pulmonary symptoms seen in this patient population. We do not recommend routine intraoperative cholangiography in patients with cystic fibrosis and gallbladder disease. Cystic fibrosis is a disease with progressive pulmonary deterioration. Cholecystectomy can be performed in these patients with relative safety if careful preoperative and postoperative care is provided. We recommend early operative intervention in the patient with gallbladder disease and cystic fibrosis.

Adolescent↗

[Anatomic abnormalities of the genital tract in ano-rectal malformations].

Of 152 patients with imperforate anus, 16 girls -25%), 10 boys (15%) have an abnormality of the genital tract and real frequency seems underevaluated. In girls, vaginal septum, bicornuate and didelphys uterus are mostly diagnosed, associated with severe unilateral upper urinary tract malformations. Absent vagina and uterus (Rokitansky syndrome) must be seen at birth, to preserve perineal fistula used to fashion a vagina at the time of the abdomino-perineal fistula pull through. In boys hypospadias, ectopia and uretero-vas anastomosis are the most frequent malformations.

Abnormalities, Multiple↗

[Anatomy and physiology of the muscles in cleft lip and palate].

The authors present the anatomy and the physiology of the normal and pathological muscles of the cleft lip and palate. The authors insist not only on the anatomic defects but mainly on the muscle functions which are the most disturbed. The purpose of this study is to guide the surgical technique in order to improve not only the cosmetic but the functional results as well.

Cleft Lip↗

Morbidity and mortality of short bowel syndrome in infancy and childhood.

This report concerns 59 infants and children with short bowel syndrome, most commonly caused by necrotizing enterocolitis in this study. Resection of atretic or gangrenous bowel was performed in 53 patients, tapering enteroplasty and primary anastomosis was performed in 13 patients, and temporary enterostomies were performed in 40 patients. Second-look laparotomy was useful in two of four cases of questionable bowel viability. The ileocecal valve was resected in 32 patients and remained intact in 27. The mean length of the remaining bowel was 58.4 cm. All patients received total parenteral nutrition and early enteral feedings. Home hyperalimentation was attempted when 50 per cent of the calorie intake was enteral. Intestinal adaptation required from 3 to 14 months. Frequent setbacks were related to catheter sepsis, rotavirus infection, carbohydrate intolerance, and liver dysfunction. The overall survival rate was 80 per cent with mortality due to sepsis associated with total parenteral nutrition and liver failure.

Adaptation, Physiological↗

[The heterotopic pancreas in children. Apropos of 4 new cases].

The authors report 4 new cases of heterotopic pancreas in children with prepyloric, jejunal, Meckel's diverticulum and mesenteric localization. Clinical manifestations were: hemorrhage in the prepyloric localization, abdominal pain in the mesenteric and Meckel's diverticulum and ileus in the jejunum localization. The authors emphasise the difficulties of preoperative diagnosis of the pancreatic heterotopias, owing to their usually small size and the necessity of surgical treatment.

Adolescent↗

Hydatid disease affecting the vertebrae.

Six cases of hydatid disease affecting the vertebrae are described. Four patients presented with paraparesis and sphincter disturbances while the other two presented with low back pain and sciatica. Myelographic findings were positive in all six patients. The CT scans showed a paravertebral mass with destruction of bone in two cases. The nuclear magnetic resonance performed in one patient showed the exact extent of the disease all along the spine. Posterior laminectomy with decompression of the spinal cord and removal of the hydatid cysts was performed in all six patients. After the operation four patients received oral treatment with mebendazole. The patients with paraparesis showed little improvement of their neurological status. The two patients with low back pain and sciatica showed marked improvement. Hydatid disease affecting the vertebrae presents with neurological complications due to cord compression. The prognosis remains poor in spite of laminectomy, although removal of the hydatid cysts and long-term mebendazole medication may result in relief of symptoms.

Adult↗

[Anatomy of the naso-labial muscles and the mesethmoid in labiomaxillary cleft. A new surgical approach of cheiloplasty].

The authors analyse the role of the ectomesenchyme in facial organogenesis, and the biology of fetal and infant cephalic development, supply valid arguments for the application of new principles in cheiloplasty for labial or labiomaxillary clefts. Instead of dermatoplasty alone, the procedure involves anatomically selective muscle reconstruction of the nasolabial confines, a structure that is predominantly muscular. Cheilomesethmoidoplasty of the transverse and nasolabial muscles of the orbicularis of the upper lip is therefore a totally valid procedure. This procedure has applied by the authors in 36 cases.

Cleft Lip↗

Tumours of the head and neck in children. A clinico-pathological analysis of 1,007 cases.

Tumours of the head and neck in children are uncommon, representing only 2-3% of all head and neck tumours. During the twenty year period 1964-1983, 12,876 childhood tumours were submitted for pathological diagnosis. Of these 1,007 (7.8%) were in the head and neck region, and it is this group that has been analysed. 30.6% (308 cases) were malignant neoplasms, 27.8% (280 cases) were benign neoplasms, 24.2% (244 cases) presented as tumour-like conditions and 17.4 (175 cases) were dysplasias arising from embryonal remnants. The overall sex ratio was 1.5:1 in favour of males. Lymphomas accounted for 15.9% overall (52.3% of the malignant neoplasms). Of benign tumours, haemangiomas were the most frequent (38.5%) and of the tumour-like conditions, dermoid and epidermoid cysts accounted for 36.1%. Of the embryonal remnant dysplasias, thyroglossal duct cysts accounted for 71.4%.

Adolescent↗

[Castleman's pseudotumor in children. Apropos of an unusual case].

A case of abdominal pseudo-tumor of Castleman disease is reported in a nine year-old boy. The patient is well without evidence of recurrence three years following resection. Castleman's disease is a benign disorder of lymph nodes that occurs rarely in children. Since the first description by Castleman in 1954, 286 other cases have been published and we could find only four cases in the 10 year and younger age group in the literature and only one case in the same group with anemia, hypergammaglobulinemia fever and weight loss. The management requires surgical resection of the enlarged nodes both for diagnosis and therapy, since the enlarged nodes can mimic malignant tumors of the lymphoid system. After surgical excision no recurrences have been reported.

Abdominal Neoplasms↗

HLA-A and B antigens and pulmonary tuberculosis in Greeks.

A significantly increased frequency of the HLA-B27 antigen was found in Greek adult patients suffering from pulmonary tuberculosis. This finding is discussed in connection with the literature, and it is suggested that the HLA system is involved in the pathogenesis of the disease.

Adult↗

The cradle of pediatric surgery.

The nearly two hundred years history of the Hôpital des Enfants-Malades in Paris is described, with special emphasis on the development of pediatric surgery in this hospital. Described is also the work of the various surgeons-in-chief, who since 1899 were also appointed professors of pediatric surgery. Progress was slow during the first half of the nineteenth century, but after Guersant took over in 1844 the hospital became a center for this specialty.

France↗

Cranioplasty: a review of 10 cases.

Cranial defects can be the result of trauma or neoplasia. The need for repair of these defects has led to the development of many reconstructive techniques. Ten cases of cranial defects treated by various methods of cranioplasty are reported. Of the ten cases, four were treated by bone grafts, three by silastic plates, two by acrylic plates and one by a metal plate. The indications for and contra-indications to each technique are discussed.

Bone Plates↗

[Correction of subcoronal and high penile hypospadias].

The authors present a surgical procedure for the treatment of subcoronal and high penile hypospadias. According to this technique, the urethra is elongated to the extremity of the glans penis, so the anatomic and functional reestablishment of the malformation is absolutely normal. They applied this technique to twenty two cases. The results were very satisfactory.

Child↗

Prevalence of migraine in schoolchildren and some clinical comparisons between migraine with and without aura.

OBJECTIVES: To determine the prevalence of migraine and its association with age, gender, and social class and to find out whether or not the headache and nonheadache characteristics differ between children with migraine, with and without aura, using the diagnostic criteria of the International Headache Society for childhood migraine. DESIGN: Population-based study in two stages comprising an initial screening questionnaire followed by telephone interviews of children with symptoms. SETTING: Eighteen kindergarten and 39 primary and secondary schools in Thessaloniki and its semiurban areas. SUBJECTS: Four thousand children, aged 4 to 15 years, representing a random sample of 5% of schoolchildren in Thessaloniki and its semiurban areas. MAIN OUTCOME MEASURES: (1) The prevalence of migraine, (2) the connection of migraine with social class, (3) differences in the occurrence of individual symptoms between migraine with and without aura. RESULTS: The results of the present study show that migraine prevalence was 6.2% (95% confidence interval [CI], 5.4 to 7.0). The estimated prevalences of migraine with and without aura were 2.8% (95% CI, 2.3 to 3.4) and 3.4% (CI, 2.8 to 4.0), respectively. The prevalence of migraine increased with age and it was found to be almost equal in boys and girls aged 7 to 9 years or younger, but in older age groups the prevalence was higher in girls than in boys. The data showed no evidence that connected migraine with social class. It also showed that except for the aura, the headache (e.g., frequency, duration, location, quality, and severity) and nonheadache (e.g., nausea, vomiting, phonophobia, and photophobia) characteristics were no different between children with migraine, with and without aura. In conclusion, our findings indicate that migraine is a common underdiagnosed cause of severe recurrent headache in children. The findings show that childhood migraine is not connected with social class and varies with age and gender, and that except for the aura, both migraine with and without aura are so similar in their headache and nonheadache clinical characteristics that a common pathogenesis is plausible.

Adolescent↗