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Biomedical subjects

D Anagnostopoulos

Publications and source records attributed to D Anagnostopoulos.

At least 19 recordsLinked to original sources
PubMed2006

The influence of local instillation of fusidic acid on the development of microbial complications after lung resection.

The efficacy of local instillation of fusidic acid in the prevention of post-surgical microbial complications during various types of lung resection was studied. Four hundred ninety two consecutive patients who underwent 504 thoracotomies for non-small cell lung carcinoma during April 1998-May 2004 were reviewed. The 290 patients of the first period who underwent 298 thoracotomies received a chemoprophylactic regimen of intravenous cefuroxime while the 202 patients of the second period who underwent 206 thoracotomies were additionally treated with fusidic acid, irrigated with local instillation into the pleural space, for the prevention of postoperative septic complications. Patients were followed postoperatively for development of septic complications (empyema and bronchopleural fistula) as well as of pneumonia and wound infection. Seventeen patients (5.7%) of the first period developed empyema and 13 fistula (4.4%), whereas only 2 patients (1.0%) of the second period developed empyema and fistula (OR = 5.876; 95% CI, 1.343- 25.716; P = 0.008 and OR = 4.193; 95% CI, 1.003-20.130; P = 0.034, respectively). Cases of pneumonia decreased, but not significantly, from 21 (7.0%) during the first period to 9 (4.4%) during the second period (OR = 1.613; 95% CI, 0.724-3.593; P = 0.257) while cases of wound infection decreased significantly from 19 (6.4%) to 2 (1.0%) (OR = 6.567; 95% CI, 1.513-28.510; P = 0.003). During the first period 23 pathogens were found from cases of empyema and 73 pathogens from cases of pneumonia and wound infection, whereas during the second period 3 and 18 pathogens were respectively found (OR = 5.3; 95% CI, 1.570-17.888; P = 0.003, and OR = 2.804; 95% CI, 1.628-4.838; P <0.001, respectively). These results indicate that local instillation of fusidic acid in the pleural space prior to lung resection seems effective in reducing the rate of septic complications as well as of wound infections.

Aged↗
PubMed2005

Hearing and speech assessment of cleft palate patients after palatal closure. Long-term results.

OBJECTIVE: The goal of this study was the development of a clinical methodology to assess speech and hearing impairment 5 years after the primary surgical repair of the cleft and, further, to determine the relative importance and long-term consequences of each cleft type and age to the velopharyngeal and eustachian tube function in patients who did not undergo pharyngeal flap surgery following primary palatoplasty. MATERIALS AND METHODS: We evaluated with a certain assessment protocol hearing and speech abilities of 42 patients between 5 and 15 years of age: 9 with CP (cleft of the soft and hard palate), 19 with unilateral cleft lip and palate (UCLP), 14 with bilateral cleft lip and palate (BCLP), surgically treated by a team of surgeons using two different surgical techniques between 18 and 24 months of age. ACCORDING TO OUR RESULTS WE WERE ABLE TO EVALUATE: (a) the impact of hearing impairment to the development of speech in these patients. (b) The relation of hypernasality with compansatory articulation. (c) The influence of cleft type, by means of extent of the cleft palatal musculature, to speech integrity. RESULTS: Sixty-nine percent of our patients presented with mild and moderate hearing loss. Hypernasality was observed in 40.5%, compensatory articulation in 28.5% of our patients. CONCLUSIONS: Our findings indicated: (a) a simultaneous appearance of speech and hearing impairment at the same age for each cleft type post-surgically in our patients; (b) that the muscular and vomer complex rather than the anatomic extent of the cleft is a significant factor for speech outcome after surgical repair; and (c) that hypernasality is exacerbated by compensatory articulation.

Adolescent↗
PubMed1999

Giant cell fibroblastoma: an entity or a reactive phenomenon?

The histological and immunohistochemical features of four tumors displaying the characteristic pattern of Giant Cell Fibroblastoma (GCF) are presented. Three of them were found in association with classical and/or myxoid dermatofibrosarcoma protuberans, while the fourth tumor was a retroperitoneal malignant hemangiopericytoma where foci with features of GCF were found. Typical sinusoidal spaces and the bizarre mononuclear and multinucleated cells in close association to blood vessels presenting a wide spectrum of lesions of their walls are also described. These last changes led us to believe that GCF-like lesions might not always characterize an entity but could often represent a host reaction of the connective tissue to locally aggressive or malignant tumors.

Adult↗
PubMed1999

Anterior dislocation of the elbow in a child with congenital posterior dislocation of the radial head. A case report.

A 9-year-old boy presented with anterior dislocation of the left elbow associated with a long-standing posterior dislocation of the radial head. Lack of full extension of the elbow joint was reported since birth. The dislocated elbow was reduced. No treatment was undertaken for the dislocated radial head. Radiographic evidence of dysplasia of the contralateral radial head provided a significant diagnostic criterion of a congenital malformation.

Child↗
PubMed1998

Management of nocturnal enuresis in children with desmopressin and bladder physiotherapy.

In the last 2 years, 29 children with nocturnal enuresis were treated in the outpatient departments of the Departments of Urology and Pediatric Surgery of the Aristotle University, Thessaloniki. There were 22 boys and 7 girls aged 7 to 12 years. The clinical examination was normal in all cases. All children had undergone various treatments with no beneficial effect, and relapses had occurred. The patients were given desmopressin (DDAVP) nasal drops in combination with bladder physiotherapy; 77% were cured after 12 months. Physiotherapy improves the percentage of cures as the functional capacity of the bladder increases.

Adolescent↗
PubMed1998

Cystic angiomatosis of bone with massive osteolysis of the cervical spine.

The case of a 2 1/2-year-old boy with diffuse cystic angiomatosis of bone is presented. No evidence of visceral involvement was recorded. The clinical, radiographic and histologic findings during the course of the disease process are discussed. At the age of 15 years the patient died of neurologic alterations developed due to massive osteolysis and collapse of the cervical spine, and severe dyspnoea, secondary to persistent bilateral pleural effusions.

Angiomatosis↗
PubMed1998

Changing trends in the treatment of zygomaticomaxillary complex fractures: a 12-year evaluation of methods used.

PURPOSE: The efficacy of the current methods for the treatment of fractures of the zygomaticomaxillary complex was evaluated. PATIENTS AND METHODS: One thousand two hundred seventy-seven patients with fracture of the zygomaticomaxillary complex and 196 patients with fractures of the zygomatic arch that were admitted between 1984 and 1995 were evaluated. One thousand one hundred fifty surgical procedures were performed, and in 401 cases, no operative treatment was considered necessary. The Gillie's approach was used in 514 cases, intraosseous wiring in 89 cases, bone plate osteosynthesis in 322 cases, Roger-Anderson pins in 180 cases, antral packing in 17 cases, and elevation with a hook in 28 cases. RESULTS: The best results were achieved with the use of semirigid fixation with miniplates applied at one or more sites of the fractured complex, occasionally used in combination with other methods such as Roger-Anderson pins. CONCLUSIONS: Semirigid fixation with miniplates offers the most reliable method available today for the treatment of zygomatico-orbital complex fractures and has practically replaced every other method in our institution. The increased cost and occasionally the necessity to remove the hardware are the main disadvantages of the method.

Bone Nails↗
PubMed1997

Gross morphologic variations and histologic changes in cryptorchid testes

Cryptorchid testes are frequently accompanied by gross morphologic changes with regard to the size and shape of the testis, various degrees of detachment between the epididymis and testis, elongation of the caudal epididymis and vas deferens, as well as histologic changes. This study examined the gross and microscopic testicular, epididymal, and vas changes in relation to various parameters in 824 patients operated upon in our clinic during the last decade. The major findings were the following: (1) most patients (78.8%) were older than 4 years, and many older than 8 years (39.8%); (2) the frequency of abdominal undescended testes decreased with increasing age (P <0.1), while the frequency of suprascrotal testes increased with increasing age (P <0.001); (3) most of the undescended testes in a suprascrotal position were normal or had mild atrophy (78.7%), while those in intracanalicular, internal ring, and abdominal positions frequently presented moderate or severe atrophy (71,38%; (P <0.0001); and (4) most suprascrotal testes were either normal or had mild extension and looping of the epididymis (63.8%), while most of the intracanalicular, internal ring, and abdominal testes showed moderate or profound epididymal anomalies (63.4%; P <0.0001). We conclude that even though the necessity for early surgical correction of cryptorchidism is well established, these patients at least in our region, still tend to come very late to surgery, with consequent increased risks of infertility and malignant transformation.

Journal Article↗
PubMed1997

Ectopic bone formation in a child with a head injury: complete regression after immobilisation.

A girl aged 3 years was struck by an automobile and admitted to hospital unconscious with a head injury and a right hemiparesis. Pelvic and left femoral fractures were managed with skin traction. Three weeks after the injury the range of motion of the right hip joint was reduced and movements were painful. Radiographic examination two weeks later revealed heterotopic bone formation around the hip joint. Immobilisation was the only treatment offered. One year after injury, the ectopic ossification around the hip had resolved spontaneously, and she was able to walk independently.

Accidents, Traffic↗
PubMed1997

Torsion of spermatocele and aplasia of the vas deferens. A case report.

Torsion of a spermatocele combined with aplasia of the vas deferens is described. The purpose of this case report is that this rare condition should not be omitted from the differential diagnosis of the acute scrotum in childhood. The authors also support that the term "spermatocele" could be used in the non semen producing age of childhood, based upon the non age-dependent pathologic criteria.

Humans↗
PubMed1997

Abdominoscrotal hydrocele.

Hydrocele is among the commonest inguinal anomalies in children. One of its most unusual variants is the abdominoscrotal hydrocele, of which no more than 22 cases have been reported in the world literature. The present case is the first one in our country. In this patient the coexistence of small bilateral scrotal hydrocele and cystic abdominal mass at the right side is described. Abdominoscrotal hydrocele is an unusual cause of lower abdominal cystic tumour in association with an inguinoscrotal hydrocele in infancy.

Abdomen↗
PubMed1997

Internal fixation of hip osteotomy in children. Successful healing in 26 children without postoperative casting.

We assessed the necessity of postoperative casting when a plate was used for fixation of a proximal femoral varus osteotomy. 26 children without postoperative immobilization were compared to 17 children with a cast. No complications were encountered in either group of children and all osteotomies showed similar healing. Our findings indicate that plate fixation provides adequate stability for healing of the osteotomy.

Bone Diseases, Developmental↗
PubMed1997

Gross morphologic variations and histologic changes in cryptorchid testes.

Cryptorchid testes are frequently accompanied by gross morphologic changes with regard to the size and shape of the testis, various degrees of detachment between the epididymis and testis, elongation of the caudal epididymis and vas deferens, as well as histologic changes. This study examined the gross and microscopic testicular, epididymal, and vas changes in relation to various parameters in 824 patients operated upon in our clinic during the last decade. The major findings were the following: (1) most patients (78.8%) were older than 4 years, and many older than 8 years (39.8%); (2) the frequency of abdominal undescended testes decreased with increasing age (P <0.1), while the frequency of suprascrotal testes increased with increasing age (P <0.001); (3) most of the undescended testes in a suprascrotal position were normal or had mild atrophy (78.7%), while those in intracanalicular, internal ring, and abdominal positions frequently presented moderate or severe atrophy (71,38%; (P <0.0001); and (4) most suprascrotal testes were either normal or had mild extension and looping of the epididymis (63.8%), while most of the intracanalicular, internal ring, and abdominal testes showed moderate or profound epididymal anomalies (63.4%; P <0.0001). We conclude that even though the necessity for early surgical correction of cryptorchidism is well established, these patients at least in our region, still tend to come very late to surgery, with consequent increased risks of infertility and malignant transformation.

Adolescent↗
PubMed1997

Soft tissue angiomyolipoma. A case report.

A unique case of angiomyolipoma developed in the deep soft tissues of the lower extremity of a 79 year old woman is presented. The initial tumor was misinterpreted as an ordinary lipoma and the recognition of the entity was accomplished only in the recurrent tumor and after the re-evaluation of the slides from the former tumor. The extensive fibroplasia and the bizarre appearance of many proliferating fibroblasts found in the recurrent tumor have been attributed to local host reaction and degenerative changes. However, these changes may create an alarming histologic pattern to the tumor, which need to be differentiated from a lipo- or leiomyosarcoma.

Aged↗
PubMed1995

Separator of the dura mater from the inner surface of the skull.

A simple instrument used in the detachment of the dura mater from the inner surface of the skull is presented. This separator is a hollow tube attached to a syringe. It bears a convex tip lightly pressing and detaching the dura. Saline solution given through the syringe comes out at the tip of the separator and easily, safely, and effectively detaches the dura.

Craniotomy↗
PubMed1995

Spinal extradural angiolipoma.

We present a case of an extradural thoracic spinal angiolipoma in a 27-year-old woman. The epidural tumor was evaluated with computerized tomographic scans and magnetic resonance imaging scans. The tumor was removed, and the clinical symptoms improved remarkably.

Adult↗